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Jason Moffat

ORCID

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 25

Top Venues

Nature communications

Nature chemical biology

Nature

Molecular systems biology

University of Toronto

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Toronto

Canada

Professor :: Donnelly Centre, Department of Molecular Genetics, Institute of Biomedical Engineering

Education History

University of Toronto

Canada

PHD :: Department of Molecular Genetics

Publications

Manja Friese-Hamim, Maria J Ortiz-Ruiz, Olga Bogatyrova, Marina Keil, Felix Rohdich, Beatrix Blume, Birgitta Leuthner, Frank Czauderna, Diane Hahn, Julia Jabs, Frank Jaehrling, Timo Heinrich, Roland Kellner, Katherine Chan, Amy H Y Tong, Dirk Wienke, Jason Moffat, Andree Blaukat, Frank T Zenke
Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models. Molecular cancer therapeutics (2023)
Michelle M Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian A Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G Fox, Ashley A Adile, David Bakhshinyan, Kevin R Brown, William D Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam J Fleming, Kristin Hope, John P Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J Wechsler-Reya, Gene W Yeo, Sheila K Singh
Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nature communications 14 (1) (2023)
Peter Lin, Corey Lourenco, Jennifer Cruickshank, Luis Palomero, Jenna E van Leeuwen, Amy H Y Tong, Katherine Chan, Samah El Ghamrasni, Miguel Angel Pujana, David W Cescon, Jason Moffat, Linda Z Penn
Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality. Cancer research (2023)
Michelle M Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian A Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G Fox, Ashley A Adile, David Bakhshinyan, Kevin R Brown, William D Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam J Fleming, Kristin Hope, John P Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J Wechsler-Reya, Gene W Yeo, Sheila K Singh
Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nature communications 14 (1) (2023)
Mahfuzur Rahman, Maximillian Billmann, Michael Costanzo, Michael Aregger, Amy H Y Tong, Katherine Chan, Henry Neil Ward, Kevin R Brown, Brenda J Andrews, Charles Boone, Jason Moffat, Chad L Myers
A method for benchmarking genetic screens reveals a predominant mitochondrial bias. Molecular systems biology 17 (5) (2022)
Chewei Anderson Chang, Jayu Jen, Shaowen Jiang, Azin Sayad, Arvind Singh Mer, Kevin R Brown, Allison M L Nixon, Avantika Dhabaria, Kwan Ho Tang, David Venet, Christos Sotiriou, Jiehui Deng, Kwok-Kin Wong, Sylvia Adams, Peter Meyn, Adriana Heguy, Jane A Skok, Aristotelis Tsirigos, Beatrix Ueberheide, Jason Moffat, Abhyudai Singh, Benjamin Haibe-Kains, Alireza Khodadadi-Jamayran, Benjamin G Neel
Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer. Cancer discovery 12 (4) (2022)
Wayne Ngo, Jamie L Y Wu, Zachary P Lin, Yuwei Zhang, Bram Bussin, Adrian Granda Farias, Abdullah M Syed, Katherine Chan, Andrea Habsid, Jason Moffat, Warren W C Chan
Identifying cell receptors for the nanoparticle protein corona using genome screens. Nature chemical biology 18 (9) (2022)
Nicholas Mikolajewicz, Rafael Gacesa, Magali Aguilera-Uribe, Kevin R Brown, Jason Moffat, Hong Han
Multi-level cellular and functional annotation of single-cell transcriptomes using scPipeline. Communications biology 5 (1) (2022)
Christoph Bock, Paul Datlinger, Florence Chardon, Matthew A Coelho, Matthew B Dong, Keith A Lawson, Tian Lu, Laetitia Maroc, Thomas M Norman, Bicna Song, Geoff Stanley, Sidi Chen, Mathew Garnett, Wei Li, Jason Moffat, Lei S Qi, Rebecca S Shapiro, Jay Shendure, Jonathan S Weissman, Xiaowei Zhuang
High-content CRISPR screening. Nature reviews. Methods primers 2 (1) (2022)
Michelle M Kameda-Smith, Helen Zhu, En-Ching Luo, Yujin Suk, Agata Xella, Brian A Yee, Chirayu Chokshi, Sansi Xing, Frederick Tan, Raymond G Fox, Ashley A Adile, David Bakhshinyan, Kevin R Brown, William D Gwynne, Minomi Subapanditha, Petar Miletic, Daniel Picard, Ian Burns, Jason Moffat, Kamil Paruch, Adam J Fleming, Kristin Hope, John P Provias, Marc Remke, Yu Lu, Tannishtha Reya, Chitra Venugopal, Jüri Reimand, Robert J Wechsler-Reya, Gene W Yeo, Sheila K Singh
Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma. Nature communications 13 (1) (2022)
Sanna N Masud, Megha Chandrashekhar, Michael Aregger, Guihong Tan, Xiaoyu Zhang, Patricia Mero, David A Pirman, Olga Zaslaver, Gromoslaw A Smolen, Zhen-Yuan Lin, Cassandra J Wong, Charles Boone, Anne-Claude Gingras, J Rafael Montenegro-Burke, Jason Moffat
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux. Nature chemical biology 18 (12) (2022)
Anne-Laure Valton, Sergey V Venev, Barbara Mair, Eraj Shafiq Khokhar, Amy H Y Tong, Matej Usaj, Katherine Chan, Athma A Pai, Jason Moffat, Job Dekker
A cohesin traffic pattern genetically linked to gene regulation. Nature structural & molecular biology (2022)
Yuqing Feng, Conglei Li, Jessica A Stewart, Philip Barbulescu, Noé Seija Desivo, Alejandro Álvarez-Quilón, Rossanna C Pezo, Madusha L W Perera, Katherine Chan, Amy Hin Yan Tong, Rukshana Mohamad-Ramshan, Maribel Berru, Diana Nakib, Gavin Li, Gholam Ali Kardar, James R Carlyle, Jason Moffat, Daniel Durocher, Javier M Di Noia, Ashok S Bhagwat, Rossanna C Pezo
FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature 600 (7888) (2021)
Henry N Ward, Michael Aregger, Thomas Gonatopoulos-Pournatzis, Maximilian Billmann, Toshiro K Ohsumi, Kevin R Brown, Benjamin J Blencowe, Jason Moffat, Chad L Myers
Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline. Nature protocols 16 (10) (2021)
Selma A Serra, Predrag Stojakovic, Ramon Amat, Fanny Rubio-Moscardo, Pablo Latorre, Gerhard Seisenbacher, David Canadell, René Böttcher, Michael Aregger, Jason Moffat, Eulalia de Nadal, Miguel A Valverde, Francesc Posas
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions. Proceedings of the National Academy of Sciences of the United States of America 118 (23) (2021)
Arthur Aubry, Joel D Pearson, Katherine Huang, Izhar Livne-Bar, Mohammad Ahmad, Madhavan Jagadeesan, Vikas Khetan, Troy Ketela, Kevin R Brown, Tao Yu, Suying Lu, Jeffrey L Wrana, Jason Moffat, Rod Bremner
Functional genomics identifies new synergistic therapies for retinoblastoma. Oncogene 39 (31) (2020)
Kevin R Brown, Barbara Mair, Martin Soste, Jason Moffat
CRISPR screens are feasible in TP53 wild-type cells. Molecular systems biology 15 (8) (2020)
Michael Aregger, Keith A Lawson, Maximillian Billmann, Michael Costanzo, Amy H Y Tong, Katherine Chan, Mahfuzur Rahman, Kevin R Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J Wong, Alexander Weiss, Patricia Mero, James W Dennis, Anne-Claude Gingras, Chad L Myers, Brenda J Andrews, Charles Boone, Jason Moffat
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nature metabolism 2 (6) (2020)
Keith A Lawson, Cristovão M Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A Krall, Donald M Simons, Chloe J Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E Goldford, Sarah Martin, Qian Huang, Elizabeth A Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H Brumell, Antonio Finelli, Laurie Ailles, Gary D Baider, Gromoslaw A Smolen, Gillian A Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Nature 586 (7827) (2020)
Julian Lamanna, Erica Y Scott, Harrison S Edwards, M Dean Chamberlain, Michael D M Dryden, Jiaxi Peng, Barbara Mair, Adam Lee, Calvin Chan, Alexandros A Sklavounos, Austin Heffernan, Farhana Abbas, Charis Lam, Maxwell E Olson, Jason Moffat, Aaron R Wheeler
Digital microfluidic isolation of single cells for -Omics. Nature communications 11 (1) (2020)
Thomas Gonatopoulos-Pournatzis, Michael Aregger, Kevin R Brown, Shaghayegh Farhangmehr, Ulrich Braunschweig, Henry Neil Ward, Kevin C H Ha, Alexander Weiss, Maximillian Billmann, Tanja Durbic, Chad L Myers, Benjamin J Blencowe, Jason Moffat
Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform. Nature biotechnology 38 (5) (2020)
Allison M L Nixon, Alejandro Duque, Nicholas Yelle, Megan McLaughlin, Sadegh Davoudi, Nicolas M Pedley, Jennifer Haynes, Kevin R Brown, James Pan, Traver Hart, Penney M Gilbert, Sheila K Singh, Catherine A O'Brien, Sachdev S Sidhu, Jason Moffat
A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations. Scientific reports 9 (1) (2019)
Swetha Raman, Melissa Beilschmidt, Minh To, Kevin Lin, Francine Lui, Yazen Jmeian, Mark Ng, Minerva Fernandez, Ying Fu, Keith Mascall, Alejandro Duque, Xiaowei Wang, Guohua Pan, Stephane Angers, Jason Moffat, Sachdev S Sidhu, Jeanne Magram, Angus M Sinclair, Johan Fransson, Jean-Philippe Julien
Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proceedings of the National Academy of Sciences of the United States of America 116 (14) (2019)
Barbara Mair, Peter M Aldridge, Randy S Atwal, David Philpott, Meng Zhang, Sanna N Masud, Mahmoud Labib, Amy H Y Tong, Edward H Sargent, Stephane Angers, Jason Moffat, Shana O Kelley
High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Nature biomedical engineering 3 (10) (2019)
Zvezdan Pavlovic, Jarrett J Adams, Levi L Blazer, Amandeep K Gakhal, Nick Jarvik, Zachary Steinhart, Mélanie Robitaille, Keith Mascall, James Pan, Stephane Angers, Jason Moffat, Sachdev S Sidhu
A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties. mAbs 10 (8) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jason Moffat