Feng Zhang

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 41

Top Topics

Circulating Tumor

Top Venues

Science (New York, N.Y.)

Nature communications

Nature biotechnology

This page only lists publications with an associated author ORCID identifier.

Publications

Yutaro Shuto, Ryoya Nakagawa, Shiyou Zhu, Mizuki Hoki, Satoshi N Omura, Hisato Hirano, Yuzuru Itoh, Feng Zhang, Osamu Nureki
Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature 631 (8019) (2024)
Yutaro Shuto, Ryoya Nakagawa, Shiyou Zhu, Mizuki Hoki, Satoshi N Omura, Hisato Hirano, Yuzuru Itoh, Feng Zhang, Osamu Nureki
Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature 631 (8019) (2024)
Yutaro Shuto, Ryoya Nakagawa, Shiyou Zhu, Mizuki Hoki, Satoshi N Omura, Hisato Hirano, Yuzuru Itoh, Feng Zhang, Osamu Nureki
Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature 631 (8019) (2024)
Max E Wilkinson, David Li, Linyi Alex Gao, Rhiannon K Macrae, Feng Zhang
Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA. Science (New York, N.Y.) (2024)
Yutaro Shuto, Ryoya Nakagawa, Shiyou Zhu, Mizuki Hoki, Satoshi N Omura, Hisato Hirano, Yuzuru Itoh, Feng Zhang, Osamu Nureki
Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature 631 (8019) (2024)
Yutaro Shuto, Ryoya Nakagawa, Shiyou Zhu, Mizuki Hoki, Satoshi N Omura, Hisato Hirano, Yuzuru Itoh, Feng Zhang, Osamu Nureki
Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature 631 (8019) (2024)
Yutaro Shuto, Ryoya Nakagawa, Shiyou Zhu, Mizuki Hoki, Satoshi N Omura, Hisato Hirano, Yuzuru Itoh, Feng Zhang, Osamu Nureki
Structural basis for pegRNA-guided reverse transcription by a prime editor. Nature (2024)
Han Altae-Tran, Soumya Kannan, Anthony J Suberski, Kepler S Mears, F Esra Demircioglu, Lukas Möller, Selin Kocalar, Rachel Oshiro, Kira S Makarova, Rhiannon K Macrae, Eugene V Koonin, Feng Zhang
Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering. Science (New York, N.Y.) 382 (6673) (2023)
Anael Cain, Mariko Taga, Cristin McCabe, Gilad S Green, Idan Hekselman, Charles C White, Dylan I Lee, Pallavi Gaur, Orit Rozenblatt-Rosen, Feng Zhang, Esti Yeger-Lotem, David A Bennett, Hyun-Sik Yang, Aviv Regev, Vilas Menon, Naomi Habib, Philip Lawrence De Jager
Multicellular communities are perturbed in the aging human brain and Alzheimer's disease. Nature neuroscience (2023)
Daniel Strebinger, Chris J Frangieh, Mirco J Friedrich, Guilhem Faure, Rhiannon K Macrae, Feng Zhang
Cell type-specific delivery by modular envelope design. Nature communications 14 (1) (2023)
Ryoya Nakagawa, Hisato Hirano, Satoshi N Omura, Suchita P Nety, Soumya Kannan, Han Altae-Tran, Xiao Yao, Yuriko Sakaguchi, Takayuki Ohira, Wen Y Wu, Hiroshi Nakayama, Yutaro Shuto, Tatsuki Tanaka, Fumiya K Sano, Tsukasa Kusakizako, Yoshiaki Kise, Yuzuru Itoh, Naoshi Dohmae, John van der Oost, Tsutomu Suzuki, Feng Zhang, Osamu Nureki
Cryo-EM structure of the transposon-associated TnpB enzyme. Nature (2023)
Makoto Saito, Peiyu Xu, Guilhem Faure, Samantha Maguire, Soumya Kannan, Han Altae-Tran, Samuel Chau-Duy Tam Vo, AnAn Desimone, Rhiannon K Macrae, Feng Zhang
Fanzor is a eukaryotic programmable RNA-guided endonuclease. Nature (2023)
Joseph Kreitz, Mirco J Friedrich, Akash Guru, Blake Lash, Makoto Saito, Rhiannon K Macrae, Feng Zhang
Programmable protein delivery with a bacterial contractile injection system. Nature (2023)
Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E Marsh, Aleksandrina Goeva, Neal M Lojek, Sarah Murphy, Cassandra M White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan, Nir Hacohen, Bradley E Bernstein, Christopher K Glass, Ville Leinonen, Mathew Blurton Jones, Feng Zhang, Charles B Epstein, Evan Z Macosko, Beth Stevens
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nature immunology (2023)
Victoria Madigan, Feng Zhang, James E Dahlman
Drug delivery systems for CRISPR-based genome editors. Nature reviews. Drug discovery (2023)
Suchita P Nety, Han Altae-Tran, Soumya Kannan, F Esra Demircioglu, Guilhem Faure, Seiichi Hirano, Kepler Mears, Yugang Zhang, Rhiannon K Macrae, Feng Zhang
The Transposon-Encoded Protein TnpB Processes Its Own mRNA into ωRNA for Guided Nuclease Activity. The CRISPR journal 6 (3) (2023)
Max E Wilkinson, Chris J Frangieh, Rhiannon K Macrae, Feng Zhang
Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription. Science (New York, N.Y.) (2023)
Joseph Kreitz, Mirco J Friedrich, Akash Guru, Blake Lash, Makoto Saito, Rhiannon K Macrae, Feng Zhang
Programmable protein delivery with a bacterial contractile injection system. Nature (2023)
Joseph Kreitz, Mirco J Friedrich, Akash Guru, Blake Lash, Makoto Saito, Rhiannon K Macrae, Feng Zhang
Programmable protein delivery with a bacterial contractile injection system. Nature (2023)
Jonathan Strecker, F Esra Demircioglu, David Li, Guilhem Faure, Max E Wilkinson, Jonathan Samuel Gootenberg, Omar O Abudayyeh, Hiroshi Nishimasu, Rhiannon K Macrae, Feng Zhang
RNA-activated protein cleavage with a CRISPR-associated endopeptidase. Science (New York, N.Y.) 378 (6622) (2022)
Kazuki Kato, Sae Okazaki, Soumya Kannan, Han Altae-Tran, F Esra Demircioglu, Yukari Isayama, Junichiro Ishikawa, Masahiro Fukuda, Rhiannon K Macrae, Tomohiro Nishizawa, Kira S Makarova, Eugene V Koonin, Feng Zhang, Hiroshi Nishimasu
Structure of the IscB-ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9. Nature communications 13 (1) (2022)
Nash D Rochman, Guilhem Faure, Yuri I Wolf, Peter L Freddolino, Feng Zhang, Eugene V Koonin
Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape. mBio 13 (2) (2022)
Julia Joung, Paul C Kirchgatterer, Ankita Singh, Jang H Cho, Suchita P Nety, Rebecca C Larson, Rhiannon K Macrae, Rebecca Deasy, Yuen-Yi Tseng, Marcela V Maus, Feng Zhang
CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nature communications 13 (1) (2022)
Seiichi Hirano, Kalli Kappel, Han Altae-Tran, Guilhem Faure, Max E Wilkinson, Soumya Kannan, F Esra Demircioglu, Rui Yan, Momoko Shiozaki, Zhiheng Yu, Kira S Makarova, Eugene V Koonin, Rhiannon K Macrae, Feng Zhang
Structure of the OMEGA nickase IsrB in complex with ωRNA and target DNA. Nature 610 (7932) (2022)
Linyi Alex Gao, Max E Wilkinson, Jonathan Strecker, Kira S Makarova, Rhiannon K Macrae, Eugene V Koonin, Feng Zhang
Prokaryotic innate immunity through pattern recognition of conserved viral proteins. Science (New York, N.Y.) 377 (6607) (2022)
Hao Li, Praneeth Namburi, Jacob M Olson, Matilde Borio, Mackenzie E Lemieux, Anna Beyeler, Gwendolyn G Calhoon, Natsuko Hitora-Imamura, Austin A Coley, Avraham Libster, Aneesh Bal, Xin Jin, Huan Wang, Caroline Jia, Sourav R Choudhury, Xi Shi, Ada C Felix-Ortiz, Verónica de la Fuente, Vanessa P Barth, Hunter O King, Ehsan M Izadmehr, Jasmin S Revanna, Kanha Batra, Kyle B Fischer, Laurel R Keyes, Nancy Padilla-Coreano, Cody A Siciliano, Kenneth M McCullough, Romy Wichmann, Kerry James Ressler, Ila R Fiete, Feng Zhang, Yu-Long Li, Kay M Tye
Neurotensin orchestrates valence assignment in the amygdala. Nature 608 (7923) (2022)
Han Altae-Tran, Soumya Kannan, F Esra Demircioglu, Rachel Oshiro, Suchita P Nety, Luke J McKay, Mensur Dlakić, William P Inskeep, Kira S Makarova, Rhiannon K Macrae, Eugene V Koonin, Feng Zhang
The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases. Science (New York, N.Y.) 374 (6563) (2021)
Soumya Kannan, Han Altae-Tran, Xin Jin, Victoria J Madigan, Rachel Oshiro, Kira S Makarova, Eugene V Koonin, Feng Zhang
Compact RNA editors with small Cas13 proteins. Nature biotechnology (2021)
Xin Jin, Sean K Simmons, Amy Guo, Ashwin S Shetty, Michelle Ko, Lan Nguyen, Vahbiz Jokhi, Elise Robinson, Paul Oyler, Nathan Curry, Giulio Deangeli, Simona Lodato, Joshua Z Levin, Aviv Regev, Feng Zhang, Paola Arlotta
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes. Science (New York, N.Y.) 370 (6520) (2021)
Kerstin U Ludwig, Ricarda Maria Schmithausen, David Li, Max L Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikołaj Słabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas S Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara M Hochfeld, Eva C Beins, Ines H Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Jacob D Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon K Macrae, Markus M Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang, Jonathan L Schmid-Burgk
LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding. Nature biotechnology (2021)
Michael Segel, Blake Lash, Jingwei Song, Alim Ladha, Catherine C Liu, Xin Jin, Sergei L Mekhedov, Rhiannon K Macrae, Eugene V Koonin, Feng Zhang
Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery. Science (New York, N.Y.) 373 (6557) (2021)
Jonathan Strecker, Alim Ladha, Kira S Makarova, Eugene V Koonin, Feng Zhang
Response to Comment on "RNA-guided DNA insertion with CRISPR-associated transposases". Science (New York, N.Y.) 368 (6495) (2020)
Linyi Alex Gao, Han Altae-Tran, Francisca Böhning, Kira S Makarova, Michael Segel, Jonathan L Schmid-Burgk, Jeremy Koob, Yuri I Wolf, Eugene V Koonin, Feng Zhang
Diverse enzymatic activities mediate antiviral immunity in prokaryotes. Science (New York, N.Y.) 369 (6507) (2020)
Omar O Abudayyeh, Jonathan Samuel Gootenberg, Brian Franklin, Jeremy Koob, Max J Kellner, Alim Ladha, Julia Joung, Paul Kirchgatterer, David B T Cox, Feng Zhang
A cytosine deaminase for programmable single-base RNA editing. Science (New York, N.Y.) 365 (6451) (2019)
Jonathan Strecker, Alim Ladha, Zachary Gardner, Jonathan L Schmid-Burgk, Kira S Makarova, Eugene V Koonin, Feng Zhang
RNA-guided DNA insertion with CRISPR-associated transposases. Science (New York, N.Y.) 365 (6448) (2019)
Jonathan Samuel Gootenberg, Omar O Abudayyeh, Max J Kellner, Julia Joung, James J Collins, Feng Zhang
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6. Science (New York, N.Y.) 360 (6387) (2018)
Hiroshi Nishimasu, Xi Shi, Soh Ishiguro, Linyi Gao, Seiichi Hirano, Sae Okazaki, Taichi Noda, Omar O Abudayyeh, Jonathan Samuel Gootenberg, Hideto Mori, Seiya Oura, Benjamin Holmes, Mamoru Tanaka, Motoaki Seki, Hisato Hirano, Hiroyuki Aburatani, Ryuichiro Ishitani, Masahito Ikawa, Nozomu Yachie, Feng Zhang, Osamu Nureki
Engineered CRISPR-Cas9 nuclease with expanded targeting space. Science (New York, N.Y.) 361 (6408) (2018)
Guangchuan Wang, Ryan D Chow, Lupeng Ye, Christopher D Guzman, Xiaoyun Dai, Matthew B Dong, Feng Zhang, Phillip A Sharp, Randall J Platt, Sidi Chen
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening. Science advances 4 (2) (2018)
Cameron A Myhrvold, Catherine A Freije, Jonathan Samuel Gootenberg, Omar O Abudayyeh, Hayden C Metsky, Ann F Durbin, Max J Kellner, Amanda L Tan, Lauren M Paul, Leda A Parham, Kimberly F Garcia, Kayla G Barnes, Bridget Chak, Adriano Mondini, Mauricio Lacerda Nogueira, Sharon Isern, Scott F Michael, Ivette Lorenzana, Nathan L Yozwiak, Bronwyn L MacInnis, Irene Bosch, Lee Gehrke, Feng Zhang, Pardis C Sabeti
Field-deployable viral diagnostics using CRISPR-Cas13. Science (New York, N.Y.) 360 (6387) (2018)
David B T Cox, Jonathan Samuel Gootenberg, Omar O Abudayyeh, Brian Franklin, Max J Kellner, Julia Joung, Feng Zhang
RNA editing with CRISPR-Cas13. Science (New York, N.Y.) 358 (6366) (2017)
Jonathan Samuel Gootenberg, Omar O Abudayyeh, Jeong Wook Lee, Patrick Essletzbichler, Aaron J Dy, Julia Joung, Vanessa Verdine, Nina Donghia, Nichole M Daringer, Catherine A Freije, Cameron A Myhrvold, Roby P Bhattacharyya, Jonathan Livny, Aviv Regev, Eugene V Koonin, Deborah T Hung, Pardis C Sabeti, James J Collins, Feng Zhang
Nucleic acid detection with CRISPR-Cas13a/C2c2. Science (New York, N.Y.) 356 (6336) (2017)