Stephan Alexander Pless (S A Pless, Stephan A Pless)

Loop profile Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

The Journal of general physiology

Nature

eLife

University of Copenhagen

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Copenhagen

Denmark

Associate Professor :: Drug Design and Pharmacology

University of British Columbia

Canada

Postdoc :: Anaesthesiology, Pharmacology and Therapeutics

Publications

Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua
Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua
Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua
Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua
Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua
Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module. bioRxiv : the preprint server for biology (2024)
Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua
Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module. bioRxiv : the preprint server for biology (2024)
Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua
Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Federica Gasparri, Debayan Sarkar, Sarune Bielickaite, Mette Homann Poulsen, Alexander Sebastian Hauser, Stephan Alexander Pless
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity. British journal of pharmacology 179 (14) (2022)
Cameron L Noland, Han Chow Chua, Marc Kschonsak, Stephanie Andrea Heusser, Nina Braun, Timothy Chang, Christine Tam, Jia Tang, Christopher P Arthur, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh
Structure-guided unlocking of Na X reveals a non-selective tetrodotoxin-sensitive cation channel. Nature communications 13 (1) (2022)
Stephanie Andrea Heusser, Christian B Borg, Janne M Colding, Stephan Alexander Pless
Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition. eLife 11 (2022)
Alison Obergrussberger, Ilka Rinke-Weiß, Tom A Goetze, Markus Rapedius, Nina Brinkwirth, Nadine Becker, Maria Giustina Rotordam, Laura Hutchison, Paola Madau, Davide Pau, David Dalrymple, Nina Braun, Søren Friis, Stephan Alexander Pless, Niels Fertig
The suitability of high throughput automated patch clamp for physiological applications. The Journal of physiology (2021)
Marc Kschonsak, Han Chow Chua, Claudia Weidling, Nourdine Chakouri, Cameron L Noland, Katharina Schott, Timothy Chang, Christine Tam, Nidhi Patel, Christopher P Arthur, Alexander Leitner, Manu Ben-Johny, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh
Structural architecture of the human NALCN channelosome. Nature 603 (7899) (2021)
Iacopo Galleano, Hendrik Harms, Koushik Choudhury, Keith K Khoo, Lucie Delemotte, Stephan Alexander Pless
Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5. Proceedings of the National Academy of Sciences of the United States of America 118 (33) (2021)
Zeshan P Sheikh, Matthias Wulf, Søren Friis, Mike Althaus, Timothy Lynagh, Stephan Alexander Pless
The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs. The Journal of general physiology 153 (10) (2021)
Nina Braun, Søren Friis, Christian Ihling, Andrea Sinz, Jacob Andersen, Stephan Alexander Pless
High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology. PLoS biology 19 (9) (2021)
Marc Kschonsak, Han Chow Chua, Cameron L Noland, Claudia Weidling, Thomas Clairfeuille, Oskar Ørts Bahlke, Aishat Oluwanifemi Ameen, Zhong Rong Li, Christopher P Arthur, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh
Structure of the human sodium leak channel NALCN. Nature 587 (7833) (2020)
Timothy Lynagh, Stephan Kiontke, Maria Meyhoff-Madsen, Bengt H Gless, Jónas Johannesen, Sabrina Kattelmann, Anders Christiansen, Martin Dufva, Andreas H Laustsen, Kanchan Devkota, Christian A Olsen, Daniel Kümmel, Stephan Alexander Pless, Brian Lohse
Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction. Journal of medicinal chemistry 63 (22) (2020)
Keith K Khoo, I Galleano, Federica Gasparri, Ralph Wieneke, H Harms, M H Poulsen, Han Chow Chua, M Wulf, Robert Tampé, Stephan Alexander Pless
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing. Nature communications 11 (1) (2020)
Han Chow Chua, M Wulf, C Weidling, L P Rasmussen, Stephan Alexander Pless
The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium. Science advances 6 (17) (2020)
Nina Braun, Zeshan P Sheikh, Stephan Alexander Pless
The current chemical biology tool box for studying ion channels. The Journal of physiology 598 (20) (2020)
Christian B Borg, Nina Braun, Stephanie A Heusser, Yasmin Bay, Daniel Weis, Iacopo Galleano, Camilla Lund, Weihua Tian, Linda M Haugaard-Kedström, Eric P Bennett, Timothy Lynagh, Kristian Stro Mgaard, Jacob Andersen, Stephan Alexander Pless
Mechanism and site of action of big dynorphin on ASIC1a. Proceedings of the National Academy of Sciences of the United States of America 117 (13) (2020)
Federica Gasparri, Jesper Wengel, Thomas Grutter, Stephan Alexander Pless
Molecular determinants for agonist recognition and discrimination in P2X2 receptors. The Journal of general physiology 151 (7) (2019)
Alice W Wang, Michael C Yau, Caroline K Wang, Nazlee Sharmin, Runying Y Yang, Stephan Alexander Pless, Harley T Kurata
Four drug-sensitive subunits are required for maximal effect of a voltage sensor-targeted KCNQ opener. The Journal of general physiology 150 (10) (2018)
Michael C Yau, Robin Y Kim, Caroline K Wang, Jingru Li, Tarek Ammar, Runying Y Yang, Stephan Alexander Pless, Harley T Kurata
One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels. The Journal of general physiology 150 (10) (2018)
Timothy Lynagh, Yana Mikhaleva, Janne M Colding, Joel C Glover, Stephan Alexander Pless
Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes. Proceedings of the National Academy of Sciences of the United States of America 115 (33) (2018)
Daniel Callau-Vázquez, Stephan Alexander Pless, Timothy Lynagh
Investigation of Agonist Recognition and Channel Properties in a Flatworm Glutamate-Gated Chloride Channel. Biochemistry 57 (8) (2018)
Keith K Khoo, Stephan Alexander Pless
How an intrinsic ligand tunes the activity of a potassium channel. The Journal of general physiology 150 (4) (2018)
Timothy Lynagh, Vitaly V Komnatnyy, Stephan Alexander Pless
Unique Contributions of an Arginine Side Chain to Ligand Recognition in a Glutamate-gated Chloride Channel. The Journal of biological chemistry 292 (9) (2017)
Timothy Lynagh, Emelie Flood, Céline Boiteux, Matthias Wulf, Vitaly V Komnatnyy, Janne M Colding, Toby W Allen, Stephan Alexander Pless
A selectivity filter at the intracellular end of the acid-sensing ion channel pore. eLife 6 (2017)
Timothy Lynagh, José Luis Romero-Rojo, Camilla Lund, Stephan Alexander Pless
Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen. Journal of medicinal chemistry 60 (19) (2017)

Stephan Alexander Pless.css-eqlu8i{font-size:small;padding-left:4px;} (S A Pless, Stephan A Pless)

Publication Activity (10 Years)

Top Topics

Top Venues

Stephan Alexander Pless (S A Pless, Stephan A Pless)