Stephen B Shears

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 17

Top Topics

Cell Cycle Arrest

Tyrosine Kinase

Capillary Electrophoresis

Top Venues

The EMBO journal

Proceedings of the National Academy of Sciences of the United States of America

Chemical science

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Guangning Zong, Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B Shears, Huanchen Wang
Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. The EMBO journal (2024)
Guangning Zong, Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B Shears, Huanchen Wang
Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. The EMBO journal 43 (3) (2024)
Guangning Zong, Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B Shears, Huanchen Wang
Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. The EMBO journal 43 (3) (2024)
Guangning Zong, Yann Desfougères, Paloma Portela-Torres, Yong-Uk Kwon, Adolfo Saiardi, Stephen B Shears, Huanchen Wang
Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus. The EMBO journal 43 (3) (2024)
Danye Qiu, Chunfang Gu, Guizhen Liu, Kevin Ritter, Verena B Eisenbeis, Tamara Bittner, Artiom Gruzdev, Lea Seidel, Bertram Bengsch, Stephen B Shears, Henning Jacob Jessen
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues. Chemical science 14 (3) (2022)
Yubai Zhou, Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Guangning Zong, Michael A Stashko, Kenneth H Pearce, Stephen B Shears, Anutosh Chakraborty, Huanchen Wang, Xiaodong Wang
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions. Journal of medicinal chemistry 65 (9) (2022)
Huanchen Wang, Lalith Perera, Nikolaus Jork, Guangning Zong, Andrew M Riley, Barry V L Potter, Henning J Jessen, Stephen B Shears
A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop. Nature communications 13 (1) (2022)
Danye Qiu, Chunfang Gu, Guizhen Liu, Kevin Ritter, Verena B Eisenbeis, Tamara Bittner, Artiom Gruzdev, Lea Seidel, Bertram Bengsch, Stephen B Shears, Henning Jacob Jessen
Capillary electrophoresis mass spectrometry identifies new isomers of inositol pyrophosphates in mammalian tissues. Chemical science 14 (3) (2022)
Chunfang Gu, Juan Liu, Xiaojing Liu, Haibo Zhang, Ji Luo, Huanchen Wang, Jason W Locasale, Stephen B Shears
Metabolic supervision by PPIP5K, an inositol pyrophosphate kinase/phosphatase, controls proliferation of the HCT116 tumor cell line. Proceedings of the National Academy of Sciences of the United States of America 118 (10) (2021)
Xingyao Li, Chunfang Gu, Sarah Hostachy, Soumyadip Sahu, Christopher Wittwer, Henning Jacob Jessen, Dorothea Fiedler, Huanchen Wang, Stephen B Shears
Control of XPR1-dependent cellular phosphate efflux by InsP8 is an exemplar for functionally-exclusive inositol pyrophosphate signaling. Proceedings of the National Academy of Sciences of the United States of America 117 (7) (2020)
Danye Qiu, Miranda S Wilson, Verena B Eisenbeis, Robert K Harmel, Esther Riemer, Thomas M Haas, Christopher Wittwer, Nikolaus Jork, Chunfang Gu, Stephen B Shears, Gabriel Schaaf, Bernd Kammerer, Dorothea Fiedler, Adolfo Saiardi, Henning Jacob Jessen
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry. Nature communications 11 (1) (2020)
Soumyadip Sahu, Zhenzhen Wang, Xinfu Jiao, Chunfang Gu, Nikolaus Jork, Christopher Wittwer, Xingyao Li, Sarah Hostachy, Dorothea Fiedler, Huanchen Wang, Henning Jacob Jessen, Megerditch Kiledjian, Stephen B Shears
InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics. Proceedings of the National Academy of Sciences of the United States of America 117 (32) (2020)
Zhenzhen Wang, Nikolaus Jork, Tamara Bittner, Huanchen Wang, Henning Jacob Jessen, Stephen B Shears
Rapid stimulation of cellular Pi uptake by the inositol pyrophosphate InsP8 induced by its photothermal release from lipid nanocarriers using a near infra-red light-emitting diode. Chemical science 11 (37) (2020)
Andrew M Riley, Huanchen Wang, Stephen B Shears, Barry V L Potter
Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7. MedChemComm 10 (7) (2019)
Chunfang Gu, Michael A Stashko, Ana C Puhl-Rubio, Molee Chakraborty, Anutosh Chakraborty, Stephen V Frye, Kenneth H Pearce, Xiaodong Wang, Stephen B Shears, Huanchen Wang
Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. Journal of medicinal chemistry 62 (3) (2019)
Eui Jae Sung, Stephen B Shears
A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging. BMC research notes 11 (1) (2018)
Stephen B Shears
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling. Journal of cellular physiology 233 (3) (2017)