Stephen V Frye (Stephen Frye)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Topics

Acute Lymphoblastic Leukemia

Tyrosine Kinase

Structural Basis

Top Venues

Journal of medicinal chemistry

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Deyu Kong, Qiang Tian, Zhilong Chen, Hongchao Zheng, Michael A Stashko, Dan Yan, H Shelton Earp, Stephen V Frye, Deborah DeRyckere, Dmitri B Kireev, Douglas K Graham, Xiaodong Wang
Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors. Journal of medicinal chemistry (2024)
Sherri K Smart, Tsz Y Yeung, M Olivia Santos, Leon F McSwain, Xiaodong Wang, Stephen V Frye, Henry Shelton Earp, Deborah DeRyckere, Douglas K Graham
MERTK Is a Potential Therapeutic Target in Ewing Sarcoma. Cancers 16 (16) (2024)
Deyu Kong, Qiang Tian, Zhilong Chen, Hongchao Zheng, Michael A Stashko, Dan Yan, H Shelton Earp, Stephen V Frye, Deborah DeRyckere, Dmitri B Kireev, Douglas K Graham, Xiaodong Wang
Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors. Journal of medicinal chemistry 67 (7) (2024)
Deyu Kong, Qiang Tian, Zhilong Chen, Hongchao Zheng, Michael A Stashko, Dan Yan, H Shelton Earp, Stephen V Frye, Deborah DeRyckere, Dmitri B Kireev, Douglas K Graham, Xiaodong Wang
Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors. Journal of medicinal chemistry 67 (7) (2024)
Sherri K Smart, Tsz Y Yeung, M Olivia Santos, Leon F McSwain, Xiaodong Wang, Stephen V Frye, Henry Shelton Earp, Deborah DeRyckere, Douglas K Graham
MERTK Is a Potential Therapeutic Target in Ewing Sarcoma. Cancers 16 (16) (2024)
Cathy J Spangler, Aleksandra Skrajna, Caroline A Foley, Anh Nguyen, Gabrielle R Budziszewski, Dalal N Azzam, Eyla C Arteaga, Holly C Simmons, Charlotte B Smith, Nathaniel A Wesley, Emily M Wilkerson, Jeanne-Marie E McPherson, Dmitri B Kireev, Lindsey I James, Stephen V Frye, Dennis Goldfarb, Robert K McGinty
Structural basis of paralog-specific KDM2A/B nucleosome recognition. Nature chemical biology (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology 18 (3) (2023)
Gaofeng Cui, Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James Robert Thompson, David J Schuller, Alexandre Detappe, Michael T Perfetti, Lindsey I James, Stephen V Frye, Dipanjan Chowdhury, Georges Mer
An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nature communications 14 (1) (2023)
Frances M Bashore, Joel K Annor-Gyamfi, Yuhong Du, Vittorio Katis, Felix Nwogbo, Raymond G Flax, Stephen V Frye, Kenneth H Pearce, Haian Fu, Timothy M Willson, David Harold Drewry, Alison D Axtman
Fused Tetrahydroquinolines Are Interfering with Your Assay. Journal of medicinal chemistry (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology 18 (3) (2023)
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Michael A Stashko, Suzanne Ackloo, Cheryl H Arrowsmith, Lindsey I James, Pengda Liu, Kenneth H Pearce, Stephen V Frye
SETDB1 Triple Tudor Domain Ligand, ( R , R )-59, Promotes Methylation of Akt1 in Cells. ACS chemical biology (2023)
Devan J Shell, Caroline A Foley, Qinhong Wang, Chelsea M Smith, Shiva K R Guduru, Hong Zeng, Aiping Dong, Jacqueline L Norris-Drouin, Matthew Axtman, P Brian Hardy, Gaorav Gupta, Levon Halabelian, Stephen V Frye, Lindsey I James, Kenneth H Pearce
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen. Journal of medicinal chemistry (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology 18 (3) (2023)
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Michael A Stashko, Suzanne Ackloo, Cheryl H Arrowsmith, Lindsey I James, Pengda Liu, Kenneth H Pearce, Stephen V Frye
SETDB1 Triple Tudor Domain Ligand, ( R,R )-59, Promotes Methylation of Akt1 in Cells. bioRxiv : the preprint server for biology (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology 18 (3) (2023)
Stefan A Laufer, Jürgen Bajorath, Alexander Titz, Nathanael S Gray, Stephen V Frye, Dennis C Liotta
Publication Criteria and Requirements for Studies on Protein Kinase Inhibitors─What Is Expected? Journal of medicinal chemistry 65 (10) (2022)
Susanne Müller, Stephen V Frye, Jonathan B Baell
The future of chemical probes is diversity. RSC medicinal chemistry 13 (12) (2022)
Ryan J Summers, Juhi Jain, Eleana Vasileiadi, Brittany Smith, Madison L Chimenti, Tsz Y Yeung, James Kelvin, Xiaodong Wang, Stephen V Frye, H Shelton Earp, Jeffrey W Tyner, Erik C Dreaden, Deborah DeRyckere, Douglas K Graham
Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia. Cancers 14 (24) (2022)
Ryan J Summers, Juhi Jain, Eleana Vasileiadi, Brittany Smith, Madison L Chimenti, Tsz Y Yeung, James Kelvin, Xiaodong Wang, Stephen V Frye, H Shelton Earp, Jeffrey W Tyner, Erik C Dreaden, Deborah DeRyckere, Douglas K Graham
Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia. Cancers 14 (24) (2022)
Isabelle A Engelberg, Jiuyang Liu, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Samantha A Ottavi, Stephen V Frye, Tatiana G Kutateladze, Lindsey I James
Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). Journal of medicinal chemistry 64 (12) (2021)
Jason M Rohde, Surendra Karavadhi, Rajan Pragani, Li Liu, Yuhong Fang, Weihe Zhang, Andrew McIver, Hongchao Zheng, Qingyang Liu, Mindy I Davis, Daniel J Urban, Tobie D Lee, Dorian M Cheff, Melinda Hollingshead, Mark J Henderson, Natalia J Martinez, Kyle R Brimacombe, Adam Yasgar, Wei Zhao, Carleen Klumpp-Thomas, Sam Michael, Joseph Covey, William J Moore, Gordon M Stott, Zhuyin Li, Anton Simeonov, Ajit Jadhav, Stephen V Frye, Matthew D Hall, Min Shen, Xiaodong Wang, Samarjit Patnaik, Matthew B Boxer
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer. Journal of medicinal chemistry 64 (8) (2021)
Kelsey N Lamb, Sarah N Dishman, Jarod M Waybright, Isabelle A Engelberg, Justin M Rectenwald, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Kenneth H Pearce, Lindsey I James, Stephen V Frye
Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins. ACS omega 7 (1) (2021)
Ana C Puhl, Jonathan W Bogart, Victoria A Haberman, Jacob E Larson, Andre Schutzer Godoy, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Tina M Leisner, Stephen V Frye, Leslie V Parise, Albert A Bowers, Kenneth H Pearce
Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1. ACS chemical biology 15 (6) (2020)
Justin M Rectenwald, Shiva Reddy Krishna Guduru, Zhao Dang, Leonard B Collins, Yi-En Liao, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Kyle W Kaufmann, Scott M Hammond, Dmitri B Kireev, Stephen V Frye, Kenneth H Pearce
Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins. Molecules (Basel, Switzerland) 25 (4) (2020)
Alisha Holtzhausen, William Harris, Eric Ubil, Debra M Hunter, Jichen Zhao, Yuewei Zhang, Dehui Zhang, Qingyang Liu, Xiaodong Wang, Douglas K Graham, Stephen V Frye, Henry Shelton Earp
TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti-PD-1 Therapy in Melanoma. Cancer immunology research 7 (10) (2019)
Junghyun L Suh, Kimberly D Barnash, Tigran M Abramyan, Fengling Li, Juliana The, Isabelle A Engelberg, Masoud Vedadi, Peter J Brown, Dmitri B Kireev, Cheryl H Arrowsmith, Lindsey I James, Stephen V Frye
Discovery of selective activators of PRC2 mutant EED-I363M. Scientific reports 9 (1) (2019)
Hagar F Moussa, Daniel Bsteh, Ramesh Yelagandula, Carina Pribitzer, Karin Stecher, Katarina Bartalska, Luca Michetti, Jingkui Wang, Jorge A Zepeda-Martinez, Ulrich Elling, Jacob I Stuckey, Lindsey I James, Stephen V Frye, Oliver Bell
Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. Nature communications 10 (1) (2019)
Caroline A Foley, Frances Potjewyd, Kelsey N Lamb, Lindsey I James, Stephen V Frye
Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS chemical biology 15 (1) (2019)
Devon R Blake, Angelina V Vaseva, Richard G Hodge, McKenzie P Kline, Thomas S K Gilbert, Vikas Tyagi, Daowei Huang, Gabrielle C Whiten, Jacob E Larson, Xiaodong Wang, Kenneth H Pearce, Laura E Herring, Lee M Graves, Stephen V Frye, Michael J Emanuele, Adrienne D Cox, Channing J Der
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Science signaling 12 (590) (2019)
Chenxiao Da, Dehui Zhang, Michael Stashko, Eleana Vasileiadi, Rebecca E Parker, Katherine A Minson, Madeline G Huey, Justus M Huelse, Debra Hunter, Thomas S K Gilbert, Jacqueline Norris-Drouin, Michael Miley, Laura E Herring, Lee M Graves, Deborah DeRyckere, H Shelton Earp, Douglas K Graham, Stephen V Frye, Xiaodong Wang, Dmitri B Kireev
Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology. Journal of the American Chemical Society 141 (39) (2019)
Chunfang Gu, Michael A Stashko, Ana C Puhl-Rubio, Molee Chakraborty, Anutosh Chakraborty, Stephen V Frye, Kenneth H Pearce, Xiaodong Wang, Stephen B Shears, Huanchen Wang
Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis. Journal of medicinal chemistry 62 (3) (2019)
Junghyun L Suh, Brian Watts, Jacob I Stuckey, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Bradley M Dickson, Yi An, Sebastian Mathea, Eidarus Salah, Stefan Knapp, Abid Khan, Alexander T Adams, Brian D Strahl, Cari A Sagum, Mark T Bedford, Lindsey I James, Dmitri B Kireev, Stephen V Frye
Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1. Biochemistry 57 (14) (2018)
Junghyun L Suh, Brian Watts, Jacob I Stuckey, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Bradley M Dickson, Yi An, Sebastian Mathea, Eidarus Salah, Stefan Knapp, Abid Khan, Alexander T Adams, Brian D Strahl, Cari A Sagum, Mark T Bedford, Lindsey I James, Dmitri B Kireev, Stephen V Frye
Correction to "Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1". Biochemistry 57 (49) (2018)
Sharon E Hopcraft, Samantha G Pattenden, Lindsey I James, Stephen V Frye, Dirk P Dittmer, Blossom A Damania
Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS pathogens 14 (9) (2018)
Jichen Zhao, Dehui Zhang, Weihe Zhang, Michael A Stashko, Deborah DeRyckere, Eleana Vasileiadi, Rebecca E Parker, Debra Hunter, Qingyang Liu, Yuewei Zhang, Jacqueline Norris-Drouin, Bing Li, David H Drewry, Dmitri B Kireev, Douglas K Graham, Henry Shelton Earp, Stephen V Frye, Xiaodong Wang
Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. Journal of medicinal chemistry 61 (22) (2018)
Brandi M Baughman, Samantha G Pattenden, Jacqueline L Norris, Lindsey I James, Stephen V Frye
Retraction of "The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer". ACS chemical biology 13 (1) (2017)