Takuya Oguma

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 11

Top Topics

Molecular Docking

Binding Protein

Cognitive Impairment

Top Venues

Journal of medicinal chemistry

The Journal of organic chemistry

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Takuya Oguma, Kohei Jino, Kenji Nakahara, Hidetsugu Asada, Kouki Fuchino, Kotaro Nagatani, Kensuke Kouki, Ryuji Okamoto, Nozomi Takai, Ken Koda, Sayaka Fujita, Yusuke Sekiguchi, Kazuya Yasuo, Kei Mayumi, Ayane Abe, Masaaki Imono, Naotaka Horiguchi, So Iwata, Ken-Ichi Kusakabe
Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. Journal of medicinal chemistry (2024)
Takuya Oguma, Kohei Jino, Kenji Nakahara, Hidetsugu Asada, Kouki Fuchino, Kotaro Nagatani, Kensuke Kouki, Ryuji Okamoto, Nozomi Takai, Ken Koda, Sayaka Fujita, Yusuke Sekiguchi, Kazuya Yasuo, Kei Mayumi, Ayane Abe, Masaaki Imono, Naotaka Horiguchi, So Iwata, Ken-Ichi Kusakabe
Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. Journal of medicinal chemistry 67 (16) (2024)
Takuya Oguma, Kohei Jino, Kenji Nakahara, Hidetsugu Asada, Kouki Fuchino, Kotaro Nagatani, Kensuke Kouki, Ryuji Okamoto, Nozomi Takai, Ken Koda, Sayaka Fujita, Yusuke Sekiguchi, Kazuya Yasuo, Kei Mayumi, Ayane Abe, Masaaki Imono, Naotaka Horiguchi, So Iwata, Ken-Ichi Kusakabe
Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. Journal of medicinal chemistry 67 (16) (2024)
Takuya Oguma, Shota Uehara, Kenji Nakahara, Yuya Okuyama, Kouki Fuchino, Naoyuki Suzuki, Yukiko Kan, Naoki Kanegawa, Yuki Ogata, Ken-Ichi Kusakabe
A Quantum Mechanics-Based Method to Predict Intramolecular Hydrogen Bond Formation Reflecting P-glycoprotein Recognition. ACS medicinal chemistry letters 14 (2) (2023)
Takuya Oguma, Shota Uehara, Kenji Nakahara, Yuya Okuyama, Kouki Fuchino, Naoyuki Suzuki, Yukiko Kan, Naoki Kanegawa, Yuki Ogata, Ken-Ichi Kusakabe
A Quantum Mechanics-Based Method to Predict Intramolecular Hydrogen Bond Formation Reflecting P-glycoprotein Recognition. ACS medicinal chemistry letters 14 (2) (2023)
Eleanor M Landwehr, Meghan A Baker, Takuya Oguma, Hannah E Burdge, Takahiro Kawajiri, Ryan A Shenvi
Concise syntheses of GB22, GB13, and himgaline by cross-coupling and complete reduction. Science (New York, N.Y.) 375 (6586) (2022)
Jun Sato, Takuya Oguma, Kenji Yamawaki
Stereoselective Synthesis of Tricyclic β-Lactam by Sulfoxide-Directed Oxidative Lactonization from an Accessible Cephalosporin Intermediate. The Journal of organic chemistry 87 (16) (2022)
Jun Sato, Hiroki Kusano, Toshiaki Aoki, Satoru Shibuya, Katsuki Yokoo, Kazuo Komano, Takuya Oguma, Shuhei Matsumoto, Rio Nakamura, Takafumi Sato, Kenji Yamawaki
Discovery of a Tricyclic β-Lactam as a Potent Antimicrobial Agent against Carbapenem-Resistant Enterobacterales, Including Strains with Reduced Membrane Permeability and Four-Amino Acid Insertion into Penicillin-Binding Protein 3: Structure-Activity-Relationships and In Vitro and In Vivo Activities. ACS infectious diseases 8 (3) (2022)
Yuji Koriyama, Akihiro Hori, Hisanori Ito, Shuji Yonezawa, Yoshiyasu Baba, Norihiko Tanimoto, Tatsuhiko Ueno, Shiho Yamamoto, Takahiko Yamamoto, Naoya Asada, Kenji Morimoto, Shunsuke Einaru, Katsunori Sakai, Takushi Kanazu, Akihiro Matsuda, Yoshitaka Yamaguchi, Takuya Oguma, Maarten Timmers, Luc Tritsmans, Ken-Ichi Kusakabe, Akira Kato, Gaku Sakaguchi
Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial. Journal of medicinal chemistry 64 (4) (2021)
Kosuke Anan, Yasuyoshi Iso, Takuya Oguma, Kenji Nakahara, Shinji Suzuki, Takahiko Yamamoto, Eriko Matsuoka, Hisanori Ito, Gaku Sakaguchi, Shigeru Ando, Kenji Morimoto, Naoki Kanegawa, Yasuto Kido, Tomoyuki Kawachi, Tamio Fukushima, Ard Teisman, Vijay Urmaliya, Deborah Dhuyvetter, Herman Borghys, Nigel Austin, An Van Den Bergh, Peter Verboven, Francois Bischoff, Harrie J M Gijsen, Yoshinori Yamano, Ken-Ichi Kusakabe
Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden. ChemMedChem 14 (22) (2019)
Takuya Oguma, Kosuke Anan, Shinji Suzuki, Shinya Hisakawa, Akihiro Takada, Masayoshi Ogawa, Ken-Ichi Kusakabe
Synthesis of a 6-CF3-Substituted 2-Amino-dihydro-1,3-thiazine β-Secretase Inhibitor by N, N-Diethylaminosulfur Trifluoride-Mediated Chemoselective Cyclization. The Journal of organic chemistry 84 (8) (2018)