Tim R Blower

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 24

Top Venues

Nature communications

Nucleic acids research

Nature

Proceedings of the National Academy of Sciences of the United States of America

Durham University

University of Cambridge (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Durham University Jul 01 2019

United Kingdom

Associate Professor :: Department of Biosciences

Durham University Aug 03 2015 - Jun 30 2019

United Kingdom

Assistant Professor :: Department of Biosciences

Johns Hopkins School of Medicine

United States

EMBO Long-Term Fellow with Prof James Berger :: Biophysics

University of California Berkeley

United States

EMBO Long-Term Fellow with Prof James Berger :: California Institute for Quantitative Biosciences

University of Cambridge

United Kingdom

Postdoctoral researcher with Prof George Salmond :: Biochemistry

Education History

University of Cambridge Sep 01 2006 - May 15 2010

United Kingdom

PHD :: Biochemistry/Clare College

Publications

Nils Birkholz, Kotaro Kamata, Maximilian Feussner, Max E Wilkinson, Christian Cuba Samaniego, Angela Migur, Dari Kimanius, Marijn Ceelen, Sam C Went, Ben Usher, Tim R Blower, Warren P Tate, Chase L Beisel, Zasha Weinberg, Robert D Fagerlund, Simon A Jackson, Peter C Fineran
Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein. Nature (2024)
Sam C Went, David M Picton, Richard D Morgan, Andrew Nelson, Aisling Brady, Giuseppina Mariano, David T F Dryden, Darren L Smith, Nicolas Wenner, Jay C D Hinton, Tim R Blower
Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence. Nature communications 15 (1) (2024)
Nils Birkholz, Kotaro Kamata, Maximilian Feussner, Max E Wilkinson, Christian Cuba Samaniego, Angela Migur, Dari Kimanius, Marijn Ceelen, Sam C Went, Ben Usher, Tim R Blower, Warren P Tate, Chase L Beisel, Zasha Weinberg, Robert D Fagerlund, Simon A Jackson, Peter C Fineran
Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein. Nature 631 (8021) (2024)
Izaak N Beck, Tom J Arrowsmith, Matthew J Grobbelaar, Elizabeth H C Bromley, Jon Marles-Wright, Tim R Blower
Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition. Nucleic acids research 52 (4) (2024)
Sam C Went, David M Picton, Richard D Morgan, Andrew Nelson, Aisling Brady, Giuseppina Mariano, David T F Dryden, Darren L Smith, Nicolas Wenner, Jay C D Hinton, Tim R Blower
Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence. Nature communications 15 (1) (2024)
Sam C Went, David M Picton, Richard D Morgan, Andrew Nelson, Aisling Brady, Giuseppina Mariano, David T F Dryden, Darren L Smith, Nicolas Wenner, Jay C D Hinton, Tim R Blower
Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence. Nature communications 15 (1) (2024)
Nils Birkholz, Kotaro Kamata, Maximilian Feussner, Max E Wilkinson, Christian Cuba Samaniego, Angela Migur, Dari Kimanius, Marijn Ceelen, Sam C Went, Ben Usher, Tim R Blower, Warren P Tate, Chase L Beisel, Zasha Weinberg, Robert D Fagerlund, Simon A Jackson, Peter C Fineran
Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein. Nature 631 (8021) (2024)
Tom J Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K Bronowska, Pierre Genevaux, Tim R Blower
Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins. Nature communications 15 (1) (2024)
Nils Birkholz, Kotaro Kamata, Maximilian Feussner, Max E Wilkinson, Christian Cuba Samaniego, Angela Migur, Dari Kimanius, Marijn Ceelen, Sam C Went, Ben Usher, Tim R Blower, Warren P Tate, Chase L Beisel, Zasha Weinberg, Robert D Fagerlund, Simon A Jackson, Peter C Fineran
Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein. Nature (2024)
Izaak N Beck, Tom J Arrowsmith, Matthew J Grobbelaar, Elizabeth H C Bromley, Jon Marles-Wright, Tim R Blower
Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition. Nucleic acids research 52 (4) (2024)
Nils Birkholz, Kotaro Kamata, Maximilian Feussner, Max E Wilkinson, Christian Cuba Samaniego, Angela Migur, Dari Kimanius, Marijn Ceelen, Sam C Went, Ben Usher, Tim R Blower, Warren P Tate, Chase L Beisel, Zasha Weinberg, Robert D Fagerlund, Simon A Jackson, Peter C Fineran
Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein. Nature 631 (8021) (2024)
Xibing Xu, Ben Usher, Claude Gutierrez, Roland Barriot, Tom J Arrowsmith, Xue Han, Peter Redder, Olivier Neyrolles, Tim R Blower, Pierre Genevaux
MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding. Nature communications 14 (1) (2023)
Izaak N Beck, Tom J Arrowsmith, Matthew J Grobbelaar, Elizabeth H C Bromley, Jon Marles-Wright, Tim R Blower
Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition. Nucleic acids research (2023)
Afif F Bandak, Tim R Blower, Karin C Nitiss, Viraj Shah, John L Nitiss, James M Berger
Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II. Nucleic acids research (2023)
Abigail Kelly, Sam C Went, Giuseppina Mariano, Liam P Shaw, David M Picton, Samuel J Duffner, Isabel Coates, Ryan Herdman-Grant, Julia Gordeeva, Alena Drobiazko, Artem Isaev, Yan-Jiun Lee, Yvette Luyten, Richard D Morgan, Peter Weigele, Konstantin Severinov, Nicolas Wenner, Jay C D Hinton, Tim R Blower
Diverse Durham collection phages demonstrate complex BREX defense responses. Applied and environmental microbiology (2023)
Afif F Bandak, Tim R Blower, Karin C Nitiss, Raveena Gupta, Albert Y Lau, Ria Guha, John L Nitiss, James M Berger
Naturally mutagenic sequence diversity in a human type II topoisomerase. Proceedings of the National Academy of Sciences of the United States of America 120 (28) (2023)
Alejandra Guillén-García, Savannah E R Gibson, Caleb J C Jordan, Venkata K Ramaswamy, Victoria L Linthwaite, Elizabeth H C Bromley, Adrian P Brown, David R W Hodgson, Tim R Blower, Jan R R Verlet, Matteo T Degiacomi, Lars-Olof Pålsson, Martin J Cann
Allophycocyanin A is a carbon dioxide receptor in the cyanobacterial phycobilisome. Nature communications 13 (1) (2022)
David M Picton, Joshua D Harling-Lee, Samuel J Duffner, Sam C Went, Richard D Morgan, Jay C D Hinton, Tim R Blower
A widespread family of WYL-domain transcriptional regulators co-localizes with diverse phage defence systems and islands. Nucleic acids research 50 (9) (2022)
David M Picton, Yvette A Luyten, Richard D Morgan, Andrew Nelson, Darren L Smith, David T F Dryden, Jay C D Hinton, Tim R Blower
The phage defence island of a multidrug resistant plasmid uses both BREX and type IV restriction for complementary protection from viruses. Nucleic acids research 49 (19) (2021)
Jasmine M Cross, Tim R Blower, Alexander D H Kingdon, Robert Pal, David M Picton, James W Walton
Anticancer Ruthenium Complexes with HDAC Isoform Selectivity. Molecules (Basel, Switzerland) 25 (10) (2020)
Yiming Cai, Ben Usher, Claude Gutierrez, Anastasia Tolcan, Moise Mansour, Peter C Fineran, Ciarán Condon, Olivier Neyrolles, Pierre Genevaux, Tim R Blower
A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems. Science advances 6 (31) (2020)
Katie J Aldred, Tim R Blower, Robert J Kerns, James M Berger, Neil Osheroff
Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase. Proceedings of the National Academy of Sciences of the United States of America 113 (7) (2016)
Tim R Blower, Benjamin H Williamson, Robert J Kerns, James M Berger
Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America 113 (7) (2016)
Jasmine M Cross, Tim R Blower, Natalie Gallagher, Jason H Gill, Kimberly L Rockley, James W Walton
Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors. ChemPlusChem 81 (12) (2016)

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Publication Activity (10 Years)

Top Topics

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Tim R Blower