Tom D Heightman

ORCID

Publication Activity (10 Years)

Years Active: 2017-2022
Publications (10 Years): 8

Top Venues

Journal of medicinal chemistry

Chemical science

Bioconjugate chemistry

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Emiliano Tamanini, Shin Miyamura, Ildiko M Buck, Benjamin D Cons, Lee Dawson, Charlotte East, Takashi Futamura, Shintaro Goto, Charlotte Griffiths-Jones, Tetsuya Hashimoto, Tom D Heightman, Shunpei Ishikawa, Hideki Ito, Yosuke Kaneko, Tatsuya Kawato, Kazumi Kondo, Naoki Kurihara, James M McCarthy, Yukiko Mori, Tsuyoshi Nagase, Yuichiro Nakaishi, Judith Reeks, Akimasa Sato, Patrick Schöpf, Kuninori Tai, Taichi Tamai, Dominic Tisi, Alison J-A Woolford
Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. ACS medicinal chemistry letters 13 (10) (2022)
Tom D Heightman, James F Callahan, Elisabetta Chiarparin, Joseph E Coyle, Charlotte Griffiths-Jones, Ami S Lakdawala, Rachel McMenamin, Paul N Mortenson, David Norton, Torren M Peakman, Sharna J Rich, Caroline Richardson, William L Rumsey, Yolanda Sanchez, Gordon Saxty, Henriëtte M G Willems, Lawrence Wolfe, Alison J-A Woolford, Zining Wu, Hongxing Yan, Jeffrey K Kerns, Thomas G Davies
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction. Journal of medicinal chemistry 62 (9) (2019)
Honorine Lebraud, Richard A Noble, Nicole Phillips, Keisha Heam, Juan Castro, Yan Zhao, David R Newell, John Lunec, Stephen R Wedge, Tom D Heightman
Highly Potent Clickable Probe for Cellular Imaging of MDM2 and Assessing Dynamic Responses to MDM2-p53 Inhibition. Bioconjugate chemistry 29 (6) (2018)
Tom D Heightman, Valerio Berdini, Hannah Braithwaite, Ildiko M Buck, Megan Cassidy, Juan Castro, Aurélie Courtin, James E H Day, Charlotte East, Lynsey Fazal, Brent Graham, Charlotte M Griffiths-Jones, John F Lyons, Vanessa Martins, Sandra Muench, Joanne M Munck, David Norton, Marc O'Reilly, Nick Palmer, Puja Pathuri, Michael Reader, David C Rees, Sharna J Rich, Caroline Richardson, Harpreet Saini, Neil T Thompson, Nicola G Wallis, Hugh Walton, Nicola E Wilsher, Alison J-A Woolford, Michael Cooke, David Cousin, Stuart Onions, Jonathan Shannon, John Watts, Christopher W Murray
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. Journal of medicinal chemistry 61 (11) (2018)
Honorine Lebraud, Olga Surova, Aurélie Courtin, Marc O'Reilly, Chiara R Valenzano, Pär Nordlund, Tom D Heightman
Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe. Chemical science 9 (45) (2018)
Rachel Grainger, Tom D Heightman, Steven V Ley, Fabio Lima, Christopher N Johnson
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines. Chemical science 10 (8) (2018)
James Sipthorp, Honorine Lebraud, Rebecca Gilley, Andrew M Kidger, Hanneke Okkenhaug, Marc Saba-El-Leil, Sylvain Meloche, Christopher J Caunt, Simon J Cook, Tom D Heightman
Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe. Bioconjugate chemistry 28 (6) (2017)
Emiliano Tamanini, Ildiko M Buck, Gianni Chessari, Elisabetta Chiarparin, James E H Day, Martyn Frederickson, Charlotte M Griffiths-Jones, Keisha Hearn, Tom D Heightman, Aman Iqbal, Christopher N Johnson, Edward J Lewis, Vanessa Martins, Torren Peakman, Michael Reader, Sharna J Rich, George A Ward, Pamela A Williams, Nicola E Wilsher
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). Journal of medicinal chemistry 60 (11) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Tom D Heightman