Virginijus Siksnys (Virginius Siksnys)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 26

Top Topics

Pseudomonas Aeruginosa

Circulating Tumor

Top Venues

Nucleic acids research

Nature communications

Nature chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Greta Bigelyte, Brigita Duchovska, Rimante Zedaveinyte, Giedrius Sasnauskas, Tomas Sinkunas, Indre Dalgediene, Giedrė Tamulaitienė, Arunas Silanskas, Darius Kazlauskas, Lukas Valančauskas, Julene Madariaga-Marcos, Ralf Seidel, Virginijus Siksnys, Tautvydas Karvelis
Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing. Nucleic acids research (2024)
Giedrė Tamulaitienė, Dziugas Sabonis, Giedrius Sasnauskas, Audrone Ruksenaite, Arunas Silanskas, Carmel Avraham, Gal Ofir, Rotem Sorek, Mindaugas Zaremba, Virginijus Siksnys
Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature 627 (8003) (2024)
Greta Bigelyte, Brigita Duchovska, Rimante Zedaveinyte, Giedrius Sasnauskas, Tomas Sinkunas, Indre Dalgediene, Giedrė Tamulaitienė, Arunas Silanskas, Darius Kazlauskas, Lukas Valančauskas, Julene Madariaga-Marcos, Ralf Seidel, Virginijus Siksnys, Tautvydas Karvelis
Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing. Nucleic acids research 52 (6) (2024)
Giedrė Tamulaitienė, Dziugas Sabonis, Giedrius Sasnauskas, Audrone Ruksenaite, Arunas Silanskas, Carmel Avraham, Gal Ofir, Rotem Sorek, Mindaugas Zaremba, Virginijus Siksnys
Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature 627 (8003) (2024)
Giedrė Tamulaitienė, Dziugas Sabonis, Giedrius Sasnauskas, Audrone Ruksenaite, Arunas Silanskas, Carmel Avraham, Gal Ofir, Rotem Sorek, Mindaugas Zaremba, Virginijus Siksnys
Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature (2024)
Giedrė Tamulaitienė, Dziugas Sabonis, Giedrius Sasnauskas, Audrone Ruksenaite, Arunas Silanskas, Carmel Avraham, Gal Ofir, Rotem Sorek, Mindaugas Zaremba, Virginijus Siksnys
Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature 627 (8003) (2024)
Greta Bigelyte, Brigita Duchovska, Rimante Zedaveinyte, Giedrius Sasnauskas, Tomas Sinkunas, Indre Dalgediene, Giedrė Tamulaitienė, Arunas Silanskas, Darius Kazlauskas, Lukas Valančauskas, Julene Madariaga-Marcos, Ralf Seidel, Virginijus Siksnys, Tautvydas Karvelis
Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing. Nucleic acids research 52 (6) (2024)
Giedrė Tamulaitienė, Dziugas Sabonis, Giedrius Sasnauskas, Audrone Ruksenaite, Arunas Silanskas, Carmel Avraham, Gal Ofir, Rotem Sorek, Mindaugas Zaremba, Virginijus Siksnys
Activation of Thoeris antiviral system via SIR2 effector filament assembly. Nature 627 (8003) (2024)
Greta Bigelyte, Brigita Duchovska, Rimante Zedaveinyte, Giedrius Sasnauskas, Tomas Sinkunas, Indre Dalgediene, Giedrė Tamulaitienė, Arunas Silanskas, Darius Kazlauskas, Lukas Valančauskas, Julene Madariaga-Marcos, Ralf Seidel, Virginijus Siksnys, Tautvydas Karvelis
Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing. Nucleic acids research 52 (6) (2024)
Giedrius Sasnauskas, Giedrė Tamulaitienė, Gytis Druteika, Arturo Carabias, Arunas Silanskas, Darius Kazlauskas, Česlovas Venclovas, Guillermo Montoya, Tautvydas Karvelis, Virginijus Siksnys
TnpB structure reveals minimal functional core of Cas12 nuclease family. Nature (2023)
Benja-Min A Adler, Marena I Trinidad, Daniel Bellieny Rabelo, Elaine Zhang, Hannah M Karp, Petr Skopintsev, Brittney W Thornton, Rachel F Weissman, Peter H Yoon, Lin-Xing Chen, Tomas Hessler, Amy R Eggers, David Colognori, Ron S Boger, Erin E Doherty, Connor A Tsuchida, Ryan V Tran, Laura Hofman, Honglue Shi, Kevin M Wasko, Zehan Zhou, Chenglong Xia, Muntathar J Al-Shimary, Jaymin R Patel, Vienna C J X Thomas, Rithu Pattali, Matthew J Kan, Anna Vardapetyan, Alana Yang, Arushi Lahiri, Michaela F Maxwell, Andrew G Murdock, Glenn C Ramit, Hope R Henderson, Roland W Calvert, Rebecca S Bamert, Gavin J Knott, Audrone Lapinaite, Patrick Pausch, Joshua C Cofsky, Erik J Sontheimer, Blake Wiedenheft, Peter C Fineran, Stan J J Brouns, Dipali G Sashital, Brian C Thomas, Christopher T Brown, Daniela S A Goltsman, Rodolphe Barrangou, Virginijus Siksnys, Jillian F Banfield, David F Savage, Jennifer A Doudna
CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes. Nucleic acids research (2023)
Tautvydas Karvelis, Virginijus Siksnys
Mis-annotation of TnpB: case of TaRGET-ABE. Nature chemical biology (2023)
Dominik J Kauert, Julene Madariaga-Marcos, Marius Rutkauskas, Alexander Wulfken, Inga Songailiene, Tomas Sinkunas, Virginijus Siksnys, Ralf Seidel
The energy landscape for R-loop formation by the CRISPR-Cas Cascade complex. Nature structural & molecular biology (2023)
Tautvydas Karvelis, Virginijus Siksnys
Mis-annotation of TnpB: case of TaRGET-ABE. Nature chemical biology 19 (3) (2023)
Tautvydas Karvelis, Virginijus Siksnys
Mis-annotation of TnpB: case of TaRGET-ABE. Nature chemical biology 19 (3) (2023)
Pierre Aldag, Marius Rutkauskas, Julene Madariaga-Marcos, Inga Songailiene, Tomas Sinkunas, Felix Kemmerich, Dominik J Kauert, Virginijus Siksnys, Ralf Seidel
Dynamic interplay between target search and recognition for a Type I CRISPR-Cas system. Nature communications 14 (1) (2023)
Irmantas Mogila, Giedrė Tamulaitienė, Konstanty Keda, Albertas Timinskas, Audrone Ruksenaite, Giedrius Sasnauskas, Česlovas Venclovas, Virginijus Siksnys, Gintautas Tamulaitis
Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Science (New York, N.Y.) 382 (6674) (2023)
Jeremy Garb, Anna Lopatina, Aude Bernheim, Mindaugas Zaremba, Virginijus Siksnys, Sarah Melamed, Azita Leavitt, Adi Millman, Gil Amitai, Rotem Sorek
Multiple phage resistance systems inhibit infection via SIR2-dependent NAD<sup>+</sup> depletion. Nature microbiology 7 (11) (2022)
Marius Rutkauskas, Inga Songailiene, Patrick Irmisch, Felix E Kemmerich, Tomas Sinkunas, Virginijus Siksnys, Ralf Seidel
A quantitative model for the dynamics of target recognition and off-target rejection by the CRISPR-Cas Cascade complex. Nature communications 13 (1) (2022)
Tomas Urbaitis, Giedrius Gasiunas, Joshua K Young, Zhenglin Hou, Sushmitha Paulraj, Egle Godliauskaite, Mantvyda M Juskeviciene, Migle Stitilyte, Monika Jasnauskaite, Megumu Mabuchi, Gregory Brett Robb, Virginijus Siksnys
A new family of CRISPR-type V nucleases with C-rich PAM recognition. EMBO reports 23 (12) (2022)
Mindaugas Zaremba, Donata Dakineviciene, Edvardas Golovinas, Evelina Zagorskaitė, Edvinas Stankunas, Anna Lopatina, Rotem Sorek, Elena Manakova, Audrone Ruksenaite, Arunas Silanskas, Simonas Asmontas, Algirdas Grybauskas, Ugne Tylenyte, Edvinas Jurgelaitis, Rokas Grigaitis, Kęstutis Timinskas, Česlovas Venclovas, Virginijus Siksnys
Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD<sup>+</sup> depletion. Nature microbiology 7 (11) (2022)
Greta Bigelyte, Joshua K Young, Tautvydas Karvelis, Karolina Budre, Rimante Zedaveinyte, Vesna Djukanovic, Elizabeth Van Ginkel, Sushmitha Paulraj, Stephen Gasior, Spencer Jones, Lanie Feigenbutz, Grace St Clair, Pierluigi Barone, Jennifer Bohn, Ananta Acharya, Gina Zastrow-Hayes, Selgar Henkel-Heinecke, Arunas Silanskas, Ralf Seidel, Virginijus Siksnys
Miniature type V-F CRISPR-Cas nucleases enable targeted DNA modification in cells. Nature communications 12 (1) (2021)
Tautvydas Karvelis, Gytis Druteika, Greta Bigelyte, Karolina Budre, Rimante Zedaveinyte, Arunas Silanskas, Darius Kazlauskas, Česlovas Venclovas, Virginijus Siksnys
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease. Nature 599 (7886) (2021)
Giedrius Gasiunas, Joshua K Young, Tautvydas Karvelis, Darius Kazlauskas, Tomas Urbaitis, Monika Jasnauskaite, Mantvyda M Grusyte, Sushmitha Paulraj, Po-Hao Wang, Zhenglin Hou, Shane K Dooley, Mark Cigan, Clara Alarcon, N Doane Chilcoat, Greta Bigelyte, Jennifer L Curcuru, Megumu Mabuchi, Zhiyi Sun, Ryan T Fuchs, Ezra Schildkraut, Peter R Weigele, William E Jack, Gregory Brett Robb, Česlovas Venclovas, Virginijus Siksnys
A catalogue of biochemically diverse CRISPR-Cas9 orthologs. Nature communications 11 (1) (2020)
Gediminas Drabavicius, Tomas Sinkunas, Arunas Silanskas, Giedrius Gasiunas, Česlovas Venclovas, Virginijus Siksnys
DnaQ exonuclease-like domain of Cas2 promotes spacer integration in a type I-E CRISPR-Cas system. EMBO reports 19 (7) (2018)
Migle Kazlauskiene, Georgij Kostiuk, Česlovas Venclovas, Gintautas Tamulaitis, Virginijus Siksnys
A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems. Science (New York, N.Y.) 357 (6351) (2017)