Erik J Sontheimer (Erik Sontheimer)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 48

Top Topics

High Efficiency

Amyotrophic Lateral Sclerosis

Top Venues

Nature communications

The CRISPR journal

bioRxiv : the preprint server for biology

Nature biotechnology

This page only lists publications with an associated author ORCID identifier.

Publications

Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Hailey Feinzig, Hanbing Cao, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature communications 15 (1) (2024)
Tomas C Rodriguez, Leonid A Yurkovetskiy, Karthika Nagalekshmi, Chin Hung Oscar Lam, Eva Jazbec, Stacy A Maitland, Scot A Wolfe, Erik J Sontheimer, Jeremy Luban
PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing. bioRxiv : the preprint server for biology (2024)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Hailey Feinzig, Hanbing Cao, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature communications 15 (1) (2024)
Tomas C Rodriguez, Leonid A Yurkovetskiy, Karthika Nagalekshmi, Chin Hung Oscar Lam, Eva Jazbec, Stacy A Maitland, Scot A Wolfe, Erik J Sontheimer, Jeremy Luban
PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing. bioRxiv : the preprint server for biology (2024)
Tomas C Rodriguez, Leonid A Yurkovetskiy, Karthika Nagalekshmi, Chin Hung Oscar Lam, Eva Jazbec, Stacy A Maitland, Scot A Wolfe, Erik J Sontheimer, Jeremy Luban
PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing. bioRxiv : the preprint server for biology (2024)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Hailey Feinzig, Hanbing Cao, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature communications 15 (1) (2024)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Hailey Feinzig, Hanbing Cao, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature communications 15 (1) (2024)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Lin Zhao, Sabrina R T Koseki, Rachel A Silverstein, Nadia Amrani, Christina Peng, Christian Kramme, Natasha Savic, Martin Pacesa, Tomas C Rodriguez, Teodora Stan, Emma Tysinger, Lauren Hong, Vivian Yudistyra, Manvitha R Ponnapati, Joseph M Jacobson, George M Church, Noah Jakimo, Ray Truant, Martin Jinek, Benjamin P Kleinstiver, Erik J Sontheimer, Pranam Chatterjee
PAM-flexible genome editing with an engineered chimeric Cas9. Nature communications 14 (1) (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Han Zhang, Karen Kelly, Jonathan Lee, Dimas Echeverria Moreno, David A Cooper, Rebecca Panwala, Zexiang Chen, Nicholas Gaston, Gregory A Newby, Jun Xie, David R Liu, Guangping Gao, Scot A Wolfe, Anastasia Khvorova, Jonathan K Watts, Erik J Sontheimer
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo . bioRxiv : the preprint server for biology (2023)
Bin Liu, Xiaolong Dong, Chunwei Zheng, David Keener, Zexiang Chen, Haoyang Cheng, Jonathan K Watts, Wen Xue, Erik J Sontheimer
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates. Nature biotechnology (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Benja-Min A Adler, Marena I Trinidad, Daniel Bellieny Rabelo, Elaine Zhang, Hannah M Karp, Petr Skopintsev, Brittney W Thornton, Rachel F Weissman, Peter H Yoon, Lin-Xing Chen, Tomas Hessler, Amy R Eggers, David Colognori, Ron S Boger, Erin E Doherty, Connor A Tsuchida, Ryan V Tran, Laura Hofman, Honglue Shi, Kevin M Wasko, Zehan Zhou, Chenglong Xia, Muntathar J Al-Shimary, Jaymin R Patel, Vienna C J X Thomas, Rithu Pattali, Matthew J Kan, Anna Vardapetyan, Alana Yang, Arushi Lahiri, Michaela F Maxwell, Andrew G Murdock, Glenn C Ramit, Hope R Henderson, Roland W Calvert, Rebecca S Bamert, Gavin J Knott, Audrone Lapinaite, Patrick Pausch, Joshua C Cofsky, Erik J Sontheimer, Blake Wiedenheft, Peter C Fineran, Stan J J Brouns, Dipali G Sashital, Brian C Thomas, Christopher T Brown, Daniela S A Goltsman, Rodolphe Barrangou, Virginijus Siksnys, Jillian F Banfield, David F Savage, Jennifer A Doudna
CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes. Nucleic acids research (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Karthikeyan Ponnienselvan, Pengpeng Liu, Thomas Nyalile, Sarah Oikemus, Anya T Joynt, Karen Kelly, Dongsheng Guo, Zexiang Chen, Jeong Min Lee, Celia A Schiffer, Charles P Emerson, Nathan D Lawson, Jonathan K Watts, Erik J Sontheimer, Jeremy Luban, Scot A Wolfe
Addressing the dNTP bottleneck restricting prime editing activity. bioRxiv : the preprint server for biology (2023)
Chunwei Zheng, Bin Liu, Xiaolong Dong, Nicholas Gaston, Erik J Sontheimer, Wen Xue
Template-jumping prime editing enables large insertion and exon rewriting in vivo. Nature communications 14 (1) (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Han Zhang, Karen Kelly, Jonathan Lee, Dimas Echeverria Moreno, David Cooper, Rebecca Panwala, Nadia Amrani, Zexiang Chen, Nicholas Gaston, Atish Wagh, Gregory A Newby, Jun Xie, David R Liu, Guangping Gao, Scot A Wolfe, Anastasia Khvorova, Jonathan K Watts, Erik J Sontheimer
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo. Nucleic acids research (2023)
Shun-Qing Liang, Pengpeng Liu, Karthikeyan Ponnienselvan, Sneha Suresh, Zexiang Chen, Christian Kramme, Pranam Chatterjee, Julie Lihua Zhu, Erik J Sontheimer, Wen Xue, Scot A Wolfe
Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag. Nature methods (2023)
Sabrina Koseki, Lauren Hong, Vivian Yudistyra, Teodora Stan, Emma Tysinger, Rachel Silverstein, Christian Kramme, Nadia Amrani, Natasha Savic, Martin Pacesa, Tomas C Rodriguez, Manvitha Ponnapati, Joseph Jacobson, George Church, Ray Truant, Martin Jinek, Benjamin P Kleinstiver, Erik J Sontheimer, Pranam Chatterjee
PAM-Flexible Genome Editing with an Engineered Chimeric Cas9. Research square (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Carolyn R Kraus, Erik J Sontheimer
Viruses use RNA decoys to thwart CRISPR defences. Nature (2023)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Nicholas Gaston, Haoyang Cheng, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope. bioRxiv : the preprint server for biology (2023)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Nicholas Gaston, Haoyang Cheng, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope. bioRxiv : the preprint server for biology (2023)
Bin Liu, Xiaolong Dong, Haoyang Cheng, Chunwei Zheng, Zexiang Chen, Tomas C Rodriguez, Shun-Qing Liang, Wen Xue, Erik J Sontheimer
A split prime editor with untethered reverse transcriptase and circular RNA template. Nature biotechnology 40 (9) (2022)
Shun-Qing Liang, Pengpeng Liu, Jordan L Smith, Esther Mintzer, Stacy Maitland, Xiaolong Dong, Qiyuan Yang, Jonathan Lee, Cole M Haynes, Julie Lihua Zhu, Jonathan K Watts, Erik J Sontheimer, Scot A Wolfe, Wen Xue
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag. Nature communications 13 (1) (2022)
Han Zhang, Nathan Bamidele, Pengpeng Liu, Ogooluwa Ojelabi, Xin D Gao, Tomas C Rodriguez, Haoyang Cheng, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Scot A Wolfe, Wen Xue, Erik J Sontheimer
Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector. GEN biotechnology 1 (3) (2022)
Zexiang Chen, Gitali Devi, Amena Arif, Phillip D Zamore, Erik J Sontheimer, Jonathan K Watts
Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing. ACS chemical biology 17 (5) (2022)
Sukanya Iyer, Aamir Mir, Joel Vega-Badillo, Benjamin P Roscoe, Raed Ibraheim, Julie Lihua Zhu, Jooyoung Lee, Pengpeng Liu, Kevin Luk, Esther Mintzer, Dongsheng Guo, Josias Soares de Brito, Charles P Emerson, Phillip D Zamore, Erik J Sontheimer, Scot A Wolfe
Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors. The CRISPR journal 5 (5) (2022)
Katharina E Meijboom, Abbas Abdallah, Nicholas P Fordham, Hiroko Nagase, Tomas C Rodriguez, Carolyn R Kraus, Tania F Gendron, Gopinath Krishnan, Rustam Esanov, Nadja S Andrade, Matthew J Rybin, Melina Ramic, Zachary D Stephens, Alireza Edraki, Meghan T Blackwood, Aydan Kahriman, Nils Henninger, Jean-Pierre A Kocher, Michael Benatar, Michael H Brodsky, Leonard Petrucelli, Fen-Biao Gao, Erik J Sontheimer, Robert H Brown, Zane Zeier, Christian Mueller
CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro. Nature communications 13 (1) (2022)
Krishanu Saha, Erik J Sontheimer, P J Brooks, Melinda R Dwinell, Charles A Gersbach, David R Liu, Stephen A Murray, Shengdar Q Tsai, Ross C Wilson, Daniel G Anderson, Aravind Asokan, Jillian F Banfield, Krystof S Bankiewicz, Gang Bao, Jeff W M Bulte, Nenad Bursac, Jarryd M Campbell, Daniel F Carlson, Elliot L Chaikof, Zheng-Yi Chen, R Holland Cheng, Karl J Clark, David T Curiel, James E Dahlman, Benjamin E Deverman, Mary E Dickinson, Jennifer A Doudna, Stephen C Ekker, Marina E Emborg, Guoping Feng, Benjamin S Freedman, David M Gamm, Guangping Gao, Ionita C Ghiran, Peter M Glazer, Shaoqin Gong, Jason D Heaney, Jon D Hennebold, John T Hinson, Anastasia Khvorova, Samira Kiani, William R Lagor, Kit S Lam, Kam W Leong, Jon E Levine, Jennifer A Lewis, Cathleen M Lutz, Danith H Ly, Samantha Maragh, Paul B McCray, Todd C McDevitt, Oleg Mirochnitchenko, Ryuji Morizane, Niren Murthy, Randall S Prather, John A Ronald, Subhojit Roy, Sushmita Roy, Venkata Sabbisetti, W Mark Saltzman, Philip J Santangelo, David J Segal, Mary Shimoyama, Melissa C Skala, Alice F Tarantal, John C Tilton, George A Truskey, Moriel Vandsburger, Jonathan K Watts, Kevin D Wells, Scot A Wolfe, Qiaobing Xu, Wen Xue, Guohua Yi, Jiangbing Zhou, null null
The NIH Somatic Cell Genome Editing program. Nature 592 (7853) (2021)
Raed Ibraheim, Phillip W L Tai, Aamir Mir, Nida Javeed, Jiaming Wang, Tomás C Rodríguez, Suk Namkung, Samantha Nelson, Eraj Shafiq Khokhar, Esther Mintzer, Stacy Maitland, Zexiang Chen, Yueying Cao, Emmanouela Tsagkaraki, Scot A Wolfe, Dan Wang, Athma A Pai, Wen Xue, Guangping Gao, Erik J Sontheimer
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo. Nature communications 12 (1) (2021)
Emmanouela Tsagkaraki, Sarah M Nicoloro, Tiffany DeSouza, Javier Solivan-Rivera, Anand Desai, Lawrence M Lifshitz, Yuefei Shen, Mark Kelly, Adilson Guilherme, Felipe Henriques, Nadia Amrani, Raed Ibraheim, Tomas C Rodriguez, Kevin Luk, Stacy Maitland, Randall H Friedline, Lauren A Tauer, Xiaodi Hu, Jason K Kim, Scot A Wolfe, Erik J Sontheimer, Silvia Corvera, Michael P Czech
CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease. Nature communications 12 (1) (2021)
Krishna S Ghanta, Zexiang Chen, Aamir Mir, Gregoriy A Dokshin, Pranathi M Krishnamurthy, Yeonsoo Yoon, Judith Gallant, Ping Xu, Xiao-Ou Zhang, Ahmet Rasit Ozturk, Masahiro Shin, Feston Idrizi, Pengpeng Liu, Hassan Gneid, Alireza Edraki, Nathan D Lawson, Jaime A Rivera-Pérez, Erik J Sontheimer, Jonathan K Watts, Craig C Mello
5'-Modifications improve potency and efficacy of DNA donors for precision genome editing. eLife 10 (2021)
Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J Sontheimer, Guangping Gao, Terence R Flotte, Scot A Wolfe, Wen Xue
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Nature communications 12 (1) (2021)
Pranam Chatterjee, Noah Jakimo, Jooyoung Lee, Nadia Amrani, Tomás Rodríguez, Sabrina R T Koseki, Emma Tysinger, Rui Qing, Shilei Hao, Erik J Sontheimer, Joseph Jacobson
An engineered ScCas9 with broad PAM range and high specificity and activity. Nature biotechnology 38 (10) (2020)
Pranam Chatterjee, Jooyoung Lee, Lisa Nip, Sabrina R T Koseki, Emma Tysinger, Erik J Sontheimer, Joseph M Jacobson, Noah Jakimo
A Cas9 with PAM recognition for adenine dinucleotides. Nature communications 11 (1) (2020)
Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima Hidalgo-Reyes, Erik J Sontheimer, Jennifer A Doudna, Alan R Davidson, Trevor F Moraes, Yanli Wang, Karen L Maxwell
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nature communications 10 (1) (2019)
Jooyoung Lee, Haiwei Mou, Raed Ibraheim, Shun-Qing Liang, Pengpeng Liu, Wen Xue, Erik J Sontheimer
Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins. RNA (New York, N.Y.) 25 (11) (2019)
Mehmet Fatih Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F Kwok, Ankit Gupta, Nadia Amrani, Erik J Sontheimer, Julie Lihua Zhu, Scot A Wolfe
Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nature communications 9 (1) (2018)
Nadia Amrani, Xin D Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir, Raed Ibraheim, Ankit Gupta, Kanae E Sasaki, Tong Wu, Paul D Donohoue, Alexander H Settle, Alexandra M Lied, Kyle McGovern, Chris K Fuller, Peter Cameron, Thomas G Fazzio, Lihua Julie Zhu, Scot A Wolfe, Erik J Sontheimer
NmeCas9 is an intrinsically high-fidelity genome-editing platform. Genome biology 19 (1) (2018)
Aamir Mir, Julia F Alterman, Matthew R Hassler, Alexandre J Debacker, Edward Hudgens, Dimas Echeverria, Michael H Brodsky, Anastasia Khvorova, Jonathan K Watts, Erik J Sontheimer
Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nature communications 9 (1) (2018)
Jooyoung Lee, Aamir Mir, Alireza Edraki, Bianca Garcia, Nadia Amrani, Hannah E Lou, Ildar V Gainetdinov, April Pawluk, Raed Ibraheim, Xin D Gao, Pengpeng Liu, Alan R Davidson, Karen L Maxwell, Erik J Sontheimer
Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. mBio 9 (6) (2018)
Raed Ibraheim, Chun-Qing Song, Aamir Mir, Nadia Amrani, Wen Xue, Erik J Sontheimer
All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome biology 19 (1) (2018)
Mehmet Fatih Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F Kwok, Ankit Gupta, Nadia Amrani, Erik J Sontheimer, Julie Lihua Zhu, Scot A Wolfe
Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nature communications 9 (1) (2018)
Aamir Mir, Alireza Edraki, Jooyoung Lee, Erik J Sontheimer
Type II-C CRISPR-Cas9 Biology, Mechanism, and Application. ACS chemical biology 13 (2) (2017)