Jason M Crawford

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 57

Top Topics

Escherichia Coli

Transcription Factor

Patients With Inflammatory Bowel Disease

Top Venues

Journal of the American Chemical Society

Applied and environmental microbiology

This page only lists publications with an associated author ORCID identifier.

Publications

Eric D Huseman, Anna Lo, Olga Fedorova, James L Elia, Susan E Gueble, Kingson Lin, Ranjini K Sundaram, Joonseok Oh, Jinchan Liu, Fabian S Menges, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Victor S Batista, Jason M Crawford, Anna Marie Pyle, Ranjit S Bindra, Seth B Herzon
Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal of the American Chemical Society (2024)
Christina Papini, Irfan Ullah, Amalendu P Ranjan, Shuo Zhang, Qihao Wu, Krasimir A Spasov, Chunhui Zhang, Walther Mothes, Jason M Crawford, Brett D Lindenbach, Pradeep D Uchil, Priti Kumar, William L Jorgensen, Karen S Anderson
Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Autumn G York, Mathias H Skadow, Joonseok Oh, Rihao Qu, Quan D Zhou, Wei-Yuan Hsieh, Walter K Mowel, J Richard Brewer, Eleanna Kaffe, Kevin J Williams, Yuval Kluger, Stephen T Smale, Jason M Crawford, Steven J Bensinger, Richard A Flavell
IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 627 (8004) (2024)
Autumn G York, Mathias H Skadow, Joonseok Oh, Rihao Qu, Quan D Zhou, Wei-Yuan Hsieh, Walter K Mowel, J Richard Brewer, Eleanna Kaffe, Kevin J Williams, Yuval Kluger, Stephen T Smale, Jason M Crawford, Steven J Bensinger, Richard A Flavell
IL-10 constrains sphingolipid metabolism to limit inflammation. Nature (2024)
Autumn G York, Mathias H Skadow, Joonseok Oh, Rihao Qu, Quan D Zhou, Wei-Yuan Hsieh, Walter K Mowel, J Richard Brewer, Eleanna Kaffe, Kevin J Williams, Yuval Kluger, Stephen T Smale, Jason M Crawford, Steven J Bensinger, Richard A Flavell
IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 627 (8004) (2024)
Yick Chong Lam, Randy Hamchand, Nicholas C Mucci, Sarah J Kauffman, Natavan Dudkina, Emily V Reagle, Ángel M Casanova-Torres, Jessica DeCuyper, Haiwei Chen, Deguang Song, Michael G Thomas, Noah W Palm, Heidi Goodrich-Blair, Jason M Crawford
The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto- N -acyl amides with inhibitory activity against mutualistic host nematode egg hatching. Applied and environmental microbiology 90 (7) (2024)
Christina Papini, Irfan Ullah, Amalendu P Ranjan, Shuo Zhang, Qihao Wu, Krasimir A Spasov, Chunhui Zhang, Walther Mothes, Jason M Crawford, Brett D Lindenbach, Pradeep D Uchil, Priti Kumar, William L Jorgensen, Karen S Anderson
Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Autumn G York, Mathias H Skadow, Joonseok Oh, Rihao Qu, Quan D Zhou, Wei-Yuan Hsieh, Walter K Mowel, J Richard Brewer, Eleanna Kaffe, Kevin J Williams, Yuval Kluger, Stephen T Smale, Jason M Crawford, Steven J Bensinger, Richard A Flavell
IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 627 (8004) (2024)
Eric D Huseman, Anna Lo, Olga Fedorova, James L Elia, Susan E Gueble, Kingson Lin, Ranjini K Sundaram, Joonseok Oh, Jinchan Liu, Fabian S Menges, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Victor S Batista, Jason M Crawford, Anna Marie Pyle, Ranjit S Bindra, Seth B Herzon
Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal of the American Chemical Society (2024)
Eric D Huseman, Anna Lo, Olga Fedorova, James L Elia, Susan E Gueble, Kingson Lin, Ranjini K Sundaram, Joonseok Oh, Jinchan Liu, Fabian S Menges, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Victor S Batista, Jason M Crawford, Anna Marie Pyle, Ranjit S Bindra, Seth B Herzon
Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal of the American Chemical Society 146 (27) (2024)
Yick Chong Lam, Randy Hamchand, Nicholas C Mucci, Sarah J Kauffman, Natavan Dudkina, Emily V Reagle, Ángel M Casanova-Torres, Jessica DeCuyper, Haiwei Chen, Deguang Song, Michael G Thomas, Noah W Palm, Heidi Goodrich-Blair, Jason M Crawford
The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto- N -acyl amides with inhibitory activity against mutualistic host nematode egg hatching. Applied and environmental microbiology 90 (7) (2024)
Christina Papini, Irfan Ullah, Amalendu P Ranjan, Shuo Zhang, Qihao Wu, Krasimir A Spasov, Chunhui Zhang, Walther Mothes, Jason M Crawford, Brett D Lindenbach, Pradeep D Uchil, Priti Kumar, William L Jorgensen, Karen S Anderson
Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Fernando H Martins, Thibaut Rosay, Anubama Rajan, Hannah E Carter, Tayah Turocy, Andres Mejia, Jason M Crawford, Anthony W Maresso, Vanessa Sperandio
Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence. Nature microbiology (2024)
Christina Papini, Irfan Ullah, Amalendu P Ranjan, Shuo Zhang, Qihao Wu, Krasimir A Spasov, Chunhui Zhang, Walther Mothes, Jason M Crawford, Brett D Lindenbach, Pradeep D Uchil, Priti Kumar, William L Jorgensen, Karen S Anderson
Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Autumn G York, Mathias H Skadow, Joonseok Oh, Rihao Qu, Quan D Zhou, Wei-Yuan Hsieh, Walter K Mowel, J Richard Brewer, Eleanna Kaffe, Kevin J Williams, Yuval Kluger, Stephen T Smale, Jason M Crawford, Steven J Bensinger, Richard A Flavell
IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 627 (8004) (2024)
Autumn G York, Mathias H Skadow, Joonseok Oh, Rihao Qu, Quan D Zhou, Wei-Yuan Hsieh, Walter K Mowel, J Richard Brewer, Eleanna Kaffe, Kevin J Williams, Yuval Kluger, Stephen T Smale, Jason M Crawford, Steven J Bensinger, Richard A Flavell
IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 627 (8004) (2024)
Yick Chong Lam, Randy Hamchand, Nicholas C Mucci, Sarah J Kauffman, Natavan Dudkina, Emily V Reagle, Ángel M Casanova-Torres, Jessica DeCuyper, Haiwei Chen, Deguang Song, Michael G Thomas, Noah W Palm, Heidi Goodrich-Blair, Jason M Crawford
The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto- N -acyl amides with inhibitory activity against mutualistic host nematode egg hatching. Applied and environmental microbiology (2024)
Yick Chong Lam, Randy Hamchand, Nicholas C Mucci, Sarah J Kauffman, Natavan Dudkina, Emily V Reagle, Ángel M Casanova-Torres, Jessica DeCuyper, Haiwei Chen, Deguang Song, Michael G Thomas, Noah W Palm, Heidi Goodrich-Blair, Jason M Crawford
The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto- N -acyl amides with inhibitory activity against mutualistic host nematode egg hatching. Applied and environmental microbiology 90 (7) (2024)
Autumn G York, Mathias H Skadow, Joonseok Oh, Rihao Qu, Quan D Zhou, Wei-Yuan Hsieh, Walter K Mowel, J Richard Brewer, Eleanna Kaffe, Kevin J Williams, Yuval Kluger, Stephen T Smale, Jason M Crawford, Steven J Bensinger, Richard A Flavell
IL-10 constrains sphingolipid metabolism to limit inflammation. Nature (2024)
Autumn G York, Mathias H Skadow, Joonseok Oh, Rihao Qu, Quan D Zhou, Wei-Yuan Hsieh, Walter K Mowel, J Richard Brewer, Eleanna Kaffe, Kevin J Williams, Yuval Kluger, Stephen T Smale, Jason M Crawford, Steven J Bensinger, Richard A Flavell
IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 627 (8004) (2024)
Jasmina Wiemann, Iris Menéndez, Jason M Crawford, Matteo Fabbri, Jacques A Gauthier, Pincelli M Hull, Mark A Norell, Derek E G Briggs
Reply to: Amniote metabolism and the evolution of endothermy. Nature 621 (7977) (2023)
Zheng Wei, Joonseok Oh, Richard A Flavell, Jason M Crawford
Author Correction: LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. Nature (2023)
Amy Ontai-Brenning, Randy Hamchand, Jason M Crawford, Andrew L Goodman
Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen. mBio (2023)
Jasmina Wiemann, Iris Menéndez, Jason M Crawford, Matteo Fabbri, Jacques A Gauthier, Pincelli M Hull, Mark A Norell, Derek E G Briggs
Fossil biomolecules reveal an avian metabolism in the ancestral dinosaur. Nature 606 (7914) (2022)
Wooyoung Cho, Autumn G York, Rurun Wang, Thomas P Wyche, Grazia Piizzi, Richard A Flavell, Jason M Crawford
N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling. Chembiochem : a European journal of chemical biology 23 (22) (2022)
Yiyun Cao, Joonseok Oh, Mengzhao Xue, Won Jae Huh, Jiawei Wang, Jaime A Gonzalez-Hernandez, Tyler A Rice, Anjelica L Martin, Deguang Song, Jason M Crawford, Seth B Herzon, Noah W Palm
Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science (New York, N.Y.) 378 (6618) (2022)
Zheng Wei, Joonseok Oh, Richard A Flavell, Jason M Crawford
LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. Nature 609 (7926) (2022)
Alexandra Gatsios, Chung Sub Kim, Autumn G York, Richard A Flavell, Jason M Crawford
Cellular Stress-Induced Metabolites in Escherichia coli . Journal of natural products 85 (11) (2022)
Jason M Crawford, Gong-Li Tang, Seth B Herzon
Natural Products: An Era of Discovery in Organic Chemistry. The Journal of organic chemistry 86 (16) (2021)
Jhe-Hao Li, Wooyoung Cho, Randy Hamchand, Joonseok Oh, Jason M Crawford
A Conserved Nonribosomal Peptide Synthetase in Xenorhabdus bovienii Produces Citrulline-Functionalized Lipopeptides. Journal of natural products 84 (10) (2021)
Michelle A Schorn, Stefan Verhoeven, Lars Ridder, Florian Huber, Deepa D Acharya, Alexander A Aksenov, Gajender Aleti, Jamshid Amiri Moghaddam, Allegra T Aron, Saefuddin Aziz, Anelize Bauermeister, Katherine D Bauman, Martin Baunach, Christine Beemelmanns, J Michael Beman, María Victoria Berlanga-Clavero, Alex A Blacutt, Helge B Bode, Anne Boullie, Asker Brejnrod, Tim S Bugni, Alexandra Calteau, Liu Cao, Víctor J Carrión, Raquel Castelo-Branco, Shaurya Chanana, Alexander B Chase, Marc G Chevrette, Leticia V Costa-Lotufo, Jason M Crawford, Cameron R Currie, Bart Cuypers, Tam Dang, Tristan de Rond, Alyssa M Demko, Elke Dittmann, Chao Du, Christopher Drozd, Jean-Claude Dujardin, Rachel J Dutton, Anna Edlund, David Peter Fewer, Neha Garg, Julia M Gauglitz, Emily C Gentry, Lena Gerwick, Evgenia Glukhov, Harald Gross, Muriel Gugger, Dulce G Guillén Matus, Eric J N Helfrich, Benjamin-Florian Hempel, Jae-Seoun Hur, Marianna Iorio, Paul R Jensen, Kyo-Bin Kang, Leonard Kaysser, Michael P Snyder, Chung Sub Kim, Ki Hyun Kim, Irina Koester, Gabriele M König, Tiago Leao, Seoung Rak Lee, Yi-Yuan Lee, Xuanji Li, Jessica C Little, Katherine N Maloney, Daniel Männle, Christian Martin H, Andrew C McAvoy, William W Metcalf, Hosein Mohimani, Carlos Molina-Santiago, Bradley S Moore, Michael W Mullowney, Mitchell N Muskat, Louis-Felix Nothias, Ellis C O'Neill, Elizabeth I Parkinson, Daniel Petras, Jörn Piel, Emily C Pierce, Karine Pires, Raphael Reher, Diego Romero, M Caroline Roper, Michael Rust, Hamada Saad, Carmen Saenz, Laura M Sanchez, Søren Johannes Sørensen, Margherita Sosio, Roderich D Süssmuth, Douglas Sweeney, Kapil Tahlan, Regan J Thomson, Nicholas J Tobias, Amaro E Trindade-Silva, Gilles P van Wezel, Mingxun Wang, Kelly C Weldon, Fan Zhang, Nadine Ziemert, Katherine R Duncan, Max Cruesemann, Simon Rogers, Pieter C Dorrestein, Marnix H Medema, Justin Johan Jozias van der Hooft
A community resource for paired genomic and metabolomic data mining. Nature chemical biology 17 (4) (2021)
Chung Sub Kim, Tayah Turocy, Gyuri Moon, Emilee E Shine, Jason M Crawford
Escherichia coli-Derived γ-Lactams and Structurally Related Metabolites Are Produced at the Intersection of Colibactin and Fatty Acid Biosynthesis. Organic letters 23 (17) (2021)
Alexandra Gatsios, Chung Sub Kim, Jason M Crawford
Escherichia coli small molecule metabolism at the host-microorganism interface. Nature chemical biology 17 (10) (2021)
Tyler N Goddard, Jaymin R Patel, Hyun Bong Park, Jason M Crawford
Dimeric Stilbene Antibiotics Target the Bacterial Cell Wall in Drug-Resistant Gram-Positive Pathogens. Biochemistry 59 (21) (2020)
Nneoma Adaku, Hyun Bong Park, Daniel J Spakowicz, Meetu Kaushik Tiwari, Scott A Strobel, Jason M Crawford, Faye A Rogers
A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma. Journal of natural products 83 (6) (2020)
Hyun Bong Park, Zheng Wei, Joonseok Oh, Hao Xu, Chung Sub Kim, Rurun Wang, Thomas P Wyche, Grazia Piizzi, Richard A Flavell, Jason M Crawford
Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli. Nature microbiology 5 (11) (2020)
Jhe-Hao Li, Joonseok Oh, Sabine Kienesberger, Nam Yoon Kim, David J Clarke, Ellen L Zechner, Jason M Crawford
Making and Breaking Leupeptin Protease Inhibitors in Pathogenic Gammaproteobacteria. Angewandte Chemie (International ed. in English) 59 (41) (2020)
Hyun Bong Park, Tyler N Goddard, Joonseok Oh, Jaymin Patel, Zheng Wei, Corey E Perez, Brandon Q Mercado, Rurun Wang, Thomas P Wyche, Grazia Piizzi, Richard A Flavell, Jason M Crawford
Bacterial Autoimmune Drug Metabolism Transforms an Immunomodulator into Structurally and Functionally Divergent Antibiotics. Angewandte Chemie (International ed. in English) 59 (20) (2020)
Jasmina Wiemann, Jason M Crawford, Derek E G Briggs
Phylogenetic and physiological signals in metazoan fossil biomolecules. Science advances 6 (28) (2020)
Joonseok Oh, Nam Y Kim, Haiwei Chen, Noah W Palm, Jason M Crawford
An Ugi-like Biosynthetic Pathway Encodes Bombesin Receptor Subtype-3 Agonists. Journal of the American Chemical Society 141 (41) (2019)
Zheng Wei, Jason M Crawford
The Gut Microbiome Says NO to microRNA-Mediated Gene Silencing. Biochemistry 58 (16) (2019)
Mengzhao Xue, Chung Sub Kim, Alan R Healy, Kevin M Wernke, Zhixun Wang, Madeline C Frischling, Emilee E Shine, Weiwei Wang, Seth B Herzon, Jason M Crawford
Structure elucidation of colibactin and its DNA cross-links. Science (New York, N.Y.) 365 (6457) (2019)
Nam Y Kim, Tyler N Goddard, Seungjung Sohn, David A Spiegel, Jason M Crawford
Biocatalytic Reversal of Advanced Glycation End Product Modification. Chembiochem : a European journal of chemical biology 20 (18) (2019)
Alan R Healy, Kevin M Wernke, Chung Sub Kim, Nicholas R Lees, Jason M Crawford, Seth B Herzon
Synthesis and reactivity of precolibactin 886. Nature chemistry 11 (10) (2019)
Corey E Perez, Jason M Crawford
Characterization of a Hybrid Nonribosomal Peptide-Carbohydrate Biosynthetic Pathway in Photorhabdus luminescens. Biochemistry 58 (8) (2019)
Corey E Perez, Hyun Bong Park, Jason M Crawford
Functional Characterization of a Condensation Domain That Links Nonribosomal Peptide and Pteridine Biosynthetic Machineries in Photorhabdus luminescens. Biochemistry 57 (3) (2018)
Jaymin R Patel, Jason M Crawford
Microbiota-Regulated Outcomes of Human Cancer Immunotherapy via the PD-1/PD-L1 Axis. Biochemistry 57 (6) (2018)
Joonseok Oh, Jaymin R Patel, Hyun Bong Park, Jason M Crawford
β-Lactam Biotransformations Activate Innate Immunity. The Journal of organic chemistry 83 (13) (2018)
Mengzhao Xue, Emilee E Shine, Weiwei Wang, Jason M Crawford, Seth B Herzon
Characterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening. Biochemistry 57 (45) (2018)
Emilee E Shine, Mengzhao Xue, Jaymin R Patel, Alan R Healy, Yulia V Surovtseva, Seth B Herzon, Jason M Crawford
Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria. ACS chemical biology 13 (12) (2018)
Caleb N Fischer, Eric P Trautman, Jason M Crawford, Eric V Stabb, Jo Handelsman, Nichole A Broderick
Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior. eLife 6 (2017)
Thomas Tørring, Stephanie R Shames, Wooyoung Cho, Craig R Roy, Jason M Crawford
Acyl Histidines: New N-Acyl Amides from Legionella pneumophila. Chembiochem : a European journal of chemical biology 18 (7) (2017)
Prabhanshu Tripathi, Emilee E Shine, Alan R Healy, Chung Sub Kim, Seth B Herzon, Steven D Bruner, Jason M Crawford
ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance. Journal of the American Chemical Society 139 (49) (2017)
Eric P Trautman, Jason M Crawford
A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase. Biochemistry 56 (37) (2017)
Naga Sandhya Guntaka, Alan R Healy, Jason M Crawford, Seth B Herzon, Steven D Bruner
Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway. ACS chemical biology 12 (10) (2017)
Hyun Bong Park, Corey E Perez, Karl W Barber, Jesse Rinehart, Jason M Crawford
Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster. eLife 6 (2017)
Eric P Trautman, Alan R Healy, Emilee E Shine, Seth B Herzon, Jason M Crawford
Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis. Journal of the American Chemical Society 139 (11) (2017)