Webster L Santos (W L Santos)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 54

Top Venues

Journal of medicinal chemistry

Organic letters

Chemical reviews

Chemistry (Weinheim an der Bergstrasse, Germany)

Virginia Polytechnic Institute and State University

University of Virginia (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Virginia Polytechnic Institute and State University

United States

Associate Professor :: Chemistry

Virginia Polytechnic Institute and State University

United States

Assistant Professor :: Chemistry

Harvard University

United States

NIH Postdoctoral Fellow

Harvard University

United States

Teaching Fellow :: Chemistry

Education History

University of Virginia

United States

PHD

University of Virginia

United States

BSC :: Chemistry

Publications

Yugesh Kharel, T Huang, K Dunnavant, D Foster, George M P R Souza, K E Nimchuk, A R Merchak, Caitlin M Pavelec, Z J Juskiewicz, Alban Gaultier, Stephen B G Abbott, Jung-Bum Shin, Brant E Isakson, W Xu, Norbert Leitinger, Webster L Santos, Kevin R Lynch
Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target. bioRxiv : the preprint server for biology (2024)
R Justin Grams, Webster L Santos, Ion Romulus Scorei, Antonio Abad-García, Carol Ann Rosenblum, Andrei Bita, Hugo E Cerecetto, Clara Viňas, Marvin Antonio Soriano-Ursúa
The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology. Chemical reviews (2024)
Yugesh Kharel, T Huang, K Dunnavant, D Foster, George M P R Souza, K E Nimchuk, A R Merchak, Caitlin M Pavelec, Z J Juskiewicz, Alban Gaultier, Stephen B G Abbott, Jung-Bum Shin, Brant E Isakson, W Xu, Norbert Leitinger, Webster L Santos, Kevin R Lynch
Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target. bioRxiv : the preprint server for biology (2024)
R Justin Grams, Webster L Santos, Ion Romulus Scorei, Antonio Abad-García, Carol Ann Rosenblum, Andrei Bita, Hugo E Cerecetto, Clara Viňas, Marvin Antonio Soriano-Ursúa
The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology. Chemical reviews 124 (5) (2024)
R Justin Grams, Webster L Santos, Ion Romulus Scorei, Antonio Abad-García, Carol Ann Rosenblum, Andrei Bita, Hugo E Cerecetto, Clara Viňas, Marvin Antonio Soriano-Ursúa
The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology. Chemical reviews 124 (5) (2024)
Rose Campbell, Nicklas W Buchbinder, Connor Szwetkowski, Yumeng Zhu, Karla Piedl, Mindy Truong, John B Matson, Webster L Santos, Emily Mevers
Design, Synthesis, and Antifungal Activity of 3-Substituted-2( 5H )-Oxaboroles. ACS medicinal chemistry letters 15 (3) (2024)
Weipeng Li, Robert Ricker, Ka Lok Chan, Pak Fung Lau, Nicklas W Buchbinder, Johannes Krebs, Alexandra Friedrich, Zhenyang Lin, Webster L Santos, Udo Radius, Todd B Marder
Phosphine-Catalyzed 1,2-cis-Diboration of 1,3-Butadiynes. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (33) (2024)
Nicklas W Buchbinder, Long H Nguyen, Owen N Beck, Andrew D Bage, Carla Slebodnick, Webster L Santos
Chemo-, Regio-, and Stereoselective cis -Hydroboration of 1,3-Enynes: Copper-Catalyzed Access to ( Z,Z )- and ( Z,E )-2-Boryl-1,3-dienes. Organic letters 26 (29) (2024)
R Justin Grams, Webster L Santos, Ion Romulus Scorei, Antonio Abad-García, Carol Ann Rosenblum, Andrei Bita, Hugo E Cerecetto, Clara Viňas, Marvin Antonio Soriano-Ursúa
The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology. Chemical reviews 124 (5) (2024)
Nicklas W Buchbinder, Long H Nguyen, Owen N Beck, Andrew D Bage, Carla Slebodnick, Webster L Santos
Chemo-, Regio-, and Stereoselective cis -Hydroboration of 1,3-Enynes: Copper-Catalyzed Access to ( Z,Z )- and ( Z,E )-2-Boryl-1,3-dienes. Organic letters 26 (29) (2024)
Weipeng Li, Robert Ricker, Ka Lok Chan, Pak Fung Lau, Nicklas W Buchbinder, Johannes Krebs, Alexandra Friedrich, Zhenyang Lin, Webster L Santos, Udo Radius, Todd B Marder
Phosphine-catalyzed 1,2-cis-diboration of 1,3-butadiynes. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Daniel J Foster, Kyle Dunnavant, Christopher W Shrader, Marion LoPresti, Sarah Seay, Yugesh Kharel, Anne M Brown, Tao Huang, Kevin R Lynch, Webster L Santos
Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of medicinal chemistry (2024)
Daniel J Foster, Kyle Dunnavant, Christopher W Shrader, Marion LoPresti, Sarah Seay, Yugesh Kharel, Anne M Brown, Tao Huang, Kevin R Lynch, Webster L Santos
Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of medicinal chemistry 67 (13) (2024)
Yugesh Kharel, T Huang, K Dunnavant, D Foster, George M P R Souza, K E Nimchuk, A R Merchak, Caitlin M Pavelec, Z J Juskiewicz, Alban Gaultier, Stephen B G Abbott, Jung-Bum Shin, Brant E Isakson, W Xu, Norbert Leitinger, Webster L Santos, Kevin R Lynch
Assessing Spns2-dependent S1P Transport as a Prospective Therapeutic Target. bioRxiv : the preprint server for biology (2024)
Nicklas W Buchbinder, Long H Nguyen, Owen N Beck, Andrew D Bage, Carla Slebodnick, Webster L Santos
Chemo-, Regio-, and Stereoselective cis -Hydroboration of 1,3-Enynes: Copper-Catalyzed Access to ( Z,Z )- and ( Z,E )-2-Boryl-1,3-dienes. Organic letters 26 (29) (2024)
Daniel J Foster, Kyle Dunnavant, Christopher W Shrader, Marion LoPresti, Sarah Seay, Yugesh Kharel, Anne M Brown, Tao Huang, Kevin R Lynch, Webster L Santos
Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of medicinal chemistry 67 (13) (2024)
Rose Campbell, Nicklas W Buchbinder, Connor Szwetkowski, Yumeng Zhu, Karla Piedl, Mindy Truong, John B Matson, Webster L Santos, Emily Mevers
Design, Synthesis, and Antifungal Activity of 3-Substituted-2( 5H )-Oxaboroles. ACS medicinal chemistry letters 15 (3) (2024)
Daniel J Foster, Kyle Dunnavant, Christopher W Shrader, Marion LoPresti, Sarah Seay, Yugesh Kharel, Anne M Brown, Tao Huang, Kevin R Lynch, Webster L Santos
Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of medicinal chemistry 67 (13) (2024)
Nicklas W Buchbinder, Long H Nguyen, Owen N Beck, Andrew D Bage, Carla Slebodnick, Webster L Santos
Chemo-, Regio-, and Stereoselective cis -Hydroboration of 1,3-Enynes: Copper-Catalyzed Access to ( Z,Z )- and ( Z,E )-2-Boryl-1,3-dienes. Organic letters (2024)
Daniel J Foster, Kyle Dunnavant, Christopher W Shrader, Marion LoPresti, Sarah Seay, Yugesh Kharel, Anne M Brown, Tao Huang, Kevin R Lynch, Webster L Santos
Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of medicinal chemistry 67 (13) (2024)
R Justin Grams, Webster L Santos, Ion Romulus Scorei, Antonio Abad-García, Carol Ann Rosenblum, Andrei Bita, Hugo E Cerecetto, Clara Viňas, Marvin Antonio Soriano-Ursúa
The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology. Chemical reviews 124 (5) (2024)
Jacob H Murray, Ariel L Burgio, Martina Beretta, Stefan R Hargett, Thurl E Harris, Ellen Olzomer, R Justin Grams, Christopher J Garcia, Catherine Li, Joseph M Salamoun, Kyle L Hoehn, Webster L Santos
Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity. Journal of medicinal chemistry 66 (6) (2023)
Ariel L Burgio, Nicklas W Buchbinder, Webster L Santos
Regio- and Stereoselective Copper-Catalyzed Borylation-Protodeboronation of 1,3-Diynes: Access to ( Z )-1,3-Enynes. Organic letters (2023)
Ariel L Burgio, Christopher W Shrader, Yugesh Kharel, Tao Huang, Joseph M Salamoun, Kevin R Lynch, Webster L Santos
2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). Journal of medicinal chemistry (2023)
Jacob H Murray, Ariel L Burgio, Martina Beretta, Stefan R Hargett, Thurl E Harris, Ellen Olzomer, R Justin Grams, Christopher J Garcia, Catherine Li, Joseph M Salamoun, Kyle L Hoehn, Webster L Santos
Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity. Journal of medicinal chemistry (2023)
Jacob H Murray, Ariel L Burgio, Martina Beretta, Stefan R Hargett, Thurl E Harris, Ellen Olzomer, R Justin Grams, Christopher J Garcia, Catherine Li, Joseph M Salamoun, Kyle L Hoehn, Webster L Santos
Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity. Journal of medicinal chemistry 66 (6) (2023)
Connor Szwetkowski, Carla Slebodnick, Webster L Santos
Regio- and stereoselective copper-catalyzed α,β-protoboration of allenoates: access to Z -β,γ-unsaturated β-boryl esters. Organic & biomolecular chemistry 20 (16) (2022)
Russell Fritzemeier, Daniel Foster, Ashley Peralta, Michael Payette, Yugesh Kharel, Tao Huang, Kevin R Lynch, Webster L Santos
Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. Journal of medicinal chemistry 65 (11) (2022)
Shinji Tanaka, Shuqiu Zheng, Yugesh Kharel, Russell G Fritzemeier, Tao Huang, Daniel Foster, Nabin Poudel, Eibhlin Goggins, Yusuke Yamaoka, Kinga P Rudnicka, Jonathan E Lipsey, Hope V Radel, Sophia M Ryuh, Tsuyoshi Inoue, Junlan Yao, Diane L Rosin, Susan R Schwab, Webster L Santos, Kevin R Lynch, Mark D Okusa
Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney. Science translational medicine 14 (658) (2022)
Swetha Jos, Connor Szwetkowski, Carla Slebodnick, Robert Ricker, Ka Lok Chan, Wing Chun Chan, Udo Radius, Zhenyang Lin, Todd B Marder, Webster L Santos
Transition Metal-Free Regio- and Stereo-Selective trans Hydroboration of 1,3-Diynes: A Phosphine-Catalyzed Access to (E)-1-Boryl-1,3-Enynes. Chemistry (Weinheim an der Bergstrasse, Germany) 28 (63) (2022)
Johnathan Bowen, Carla Slebodnick, Webster L Santos
Phosphine-catalyzed hydroboration of propiolonitriles: access to ( E )-1,2-vinylcyanotrifluoroborate derivatives. Chemical communications (Cambridge, England) 58 (40) (2022)
Swetha Jos, Christine Tan, Pierre Thilmany, Alaâ Saadane, Carla Slebodnick, Gwilherm Evano, Webster L Santos
Phosphine-catalyzed regio- and stereo-selective hydroboration of ynamides to ( Z )-β-borylenamides. Chemical communications (Cambridge, England) (2022)
Srinath Pashikanti, Daniel J Foster, Yugesh Kharel, Anne M Brown, David R Bevan, Kevin R Lynch, Webster L Santos
Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues. ACS bio & med chem Au 2 (5) (2022)
Ashley M Gates, Swetha Jos, Webster L Santos
Ligand-free copper-catalyzed borylative defluorination: access to gem-difluoroallyl boronic acid derivatives. Organic & biomolecular chemistry (2021)
Shubhankar Kumar Bose, Lujia Mao, Laura Kuehn, Udo Radius, Jan Nekvinda, Webster L Santos, Stephen A Westcott, Patrick G Steel, Todd B Marder
First-Row d-Block Element-Catalyzed Carbon-Boron Bond Formation and Related Processes. Chemical reviews 121 (21) (2021)
Elizabeth S Childress, Joseph M Salamoun, Stefan R Hargett, Stephanie J Alexopoulos, Sing-Young Chen, Divya P Shah, José Santiago-Rivera, Christopher J Garcia, Yumin Dai, Simon P Tucker, Kyle L Hoehn, Webster L Santos
[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis. Journal of medicinal chemistry 63 (5) (2020)
R Justin Grams, Christopher J Garcia, Connor Szwetkowski, Webster L Santos
Catalytic, Transition-Metal-Free Semireduction of Propiolamide Derivatives: Scope and Mechanistic Investigation. Organic letters 22 (17) (2020)
Christopher D Sibley, Emily A Morris, Yugesh Kharel, Anne M Brown, Tao Huang, David R Bevan, Kevin R Lynch, Webster L Santos
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. Journal of medicinal chemistry 63 (3) (2020)
Xiaocui Liu, Wenbo Ming, Xiaoling Luo, Alexandra Friedrich, Jan Maier, Udo Radius, Webster L Santos, Todd B Marder
Regio- and Stereoselective Synthesis of 1,1-Diborylalkenes via Brønsted Base-Catalyzed Mixed Diboration of Alkynyl Esters and Amides with BpinBdan. European journal of organic chemistry 2020 (13) (2020)
Russell G Fritzemeier, Jan Nekvinda, Christopher M Vogels, Carol Ann Rosenblum, Carla Slebodnick, Stephen A Westcott, Webster L Santos
Organocatalytic trans Phosphinoboration of Internal Alkynes. Angewandte Chemie (International ed. in English) 59 (34) (2020)
Joseph M Salamoun, Christopher J Garcia, Stefan R Hargett, Jacob H Murray, Sing-Young Chen, Martina Beretta, Stephanie J Alexopoulos, Divya P Shah, Ellen M Olzomer, Simon P Tucker, Kyle L Hoehn, Webster L Santos
6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis. Journal of medicinal chemistry 63 (11) (2020)
Stephanie J Alexopoulos, Sing-Young Chen, Amanda E Brandon, Joseph M Salamoun, Frances L Byrne, Christopher J Garcia, Martina Beretta, Ellen M Olzomer, Divya P Shah, Ashleigh M Philp, Stefan R Hargett, Robert T Lawrence, Brendan J Lee, James Sligar, Pascal Carrive, Simon P Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J Cooney, Webster L Santos, Kyle Lee Hoehn
Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nature communications 11 (1) (2020)
R Justin Grams, Russell G Fritzemeier, Carla Slebodnick, Webster L Santos
trans-Hydroboration of Propiolamides: Access to Primary and Secondary (E)-β-Borylacrylamides. Organic letters 21 (17) (2019)
Russell G Fritzemeier, Eric J Medici, Connor Szwetkowski, Laura G Wonilowicz, Christopher D Sibley, Carla Slebodnick, Webster L Santos
Route to Air and Moisture Stable β-Difluoroboryl Acrylamides. Organic letters 21 (19) (2019)
Brittney L Worrell, Anne M Brown, Webster L Santos, David R Bevan
In Silico Characterization of Structural Distinctions between Isoforms of Human and Mouse Sphingosine Kinases for Accelerating Drug Discovery. Journal of chemical information and modeling 59 (5) (2019)
Yumin Dai, Jessica E Wynn, Ashley N Peralta, Chringma Sherpa, Bhargavi Jayaraman, Hao Li, Astha Verma, Alan D Frankel, Stuart F Le Grice, Webster L Santos
Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication. Journal of medicinal chemistry 61 (21) (2018)
Yugesh Kharel, Sayeh Agah, Tao Huang, Anna J Mendelson, Oluwafunmilayo T Eletu, Peter Barkey-Bircann, James Gesualdi, Jeffrey S Smith, Webster L Santos, Kevin R Lynch
Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. PloS one 13 (4) (2018)
Brenden A Magill, Xi Guo, Cheryl L Peck, Roberto L Reyes, Erich M See, Webster L Santos, Hans D Robinson
Multi-photon patterning of photoactive o-nitrobenzyl ligands bound to gold surfaces. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 18 (1) (2018)
Russell Fritzemeier, Ashley Gates, Xueying Guo, Zhenyang Lin, Webster L Santos
Transition Metal-Free Trans Hydroboration of Alkynoic Acid Derivatives: Experimental and Theoretical Studies. The Journal of organic chemistry 83 (17) (2018)
Russell Fritzemeier, Webster L Santos
Brønsted Base-Mediated Regio- and Stereoselective trans-Silaboration of Propargylamides: Access to 1,2-Vinylborasilanes. Chemistry (Weinheim an der Bergstrasse, Germany) 23 (61) (2017)
Elizabeth S Childress, Yugesh Kharel, Anne M Brown, David R Bevan, Kevin R Lynch, Webster L Santos
Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity. Journal of medicinal chemistry 60 (9) (2017)
Erich M See, Cheryl L Peck, Webster L Santos, Hans D Robinson
Light-Directed Patchy Particle Fabrication and Assembly from Isotropic Silver Nanoparticles. Langmuir : the ACS journal of surfaces and colloids 33 (41) (2017)
Astha Verma, Russell F Snead, Yumin Dai, Carla Slebodnick, Yinuo Yang, Haizhu Yu, Fu Yao, Webster L Santos
Substrate-Assisted, Transition-Metal-Free Diboration of Alkynamides with Mixed Diboron: Regio- and Stereoselective Access to trans-1,2-Vinyldiboronates. Angewandte Chemie (International ed. in English) 56 (18) (2017)
Elizabeth S Childress, Stephanie J Alexopoulos, Kyle L Hoehn, Webster L Santos
Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential. Journal of medicinal chemistry 61 (11) (2017)

Webster L Santos.css-eqlu8i{font-size:small;padding-left:4px;} (W L Santos)

Publication Activity (10 Years)

Top Topics

Top Venues

Webster L Santos (W L Santos)