Leo C James (Leo James)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 37

Top Topics

Top Venues

Nature structural & molecular biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Jonathan Benn, Shi Cheng, Sophie Keeling, Annabel E Smith, Marina J Vaysburd, Dorothea Böken, Lauren V C Miller, Taxiarchis Katsinelos, Catarina Franco, Elian Dupré, Clément Danis, Isabelle Landrieu, Luc Buee, David Klenerman, Leo C James, William A McEwan
Aggregate-selective removal of pathological tau by clustering-activated degraders. Science (New York, N.Y.) 385 (6712) (2024)
K M Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Boecking
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure. eLife 13 (2024)
K M Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Boecking
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure. eLife 13 (2024)
Alex B Kleinpeter, Donna L Mallery, Nadine Renner, Anna Albecka, J Ole Klarhof, Eric O Freed, Leo C James
HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly. Nature communications 15 (1) (2024)
K M Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Boecking
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure. eLife 13 (2024)
K M Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Boecking
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure. eLife 13 (2024)
Nadine Renner, Alex B Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Boecking, Adolfo Saiardi, Eric O Freed, Leo C James
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nature structural & molecular biology (2023)
Guido Papa, Anna Albecka, Donna L Mallery, Marina Vaysburd, Nadine Renner, Leo C James
IP6-stabilised HIV capsids evade cGAS/STING-mediated host immune sensing. EMBO reports (2023)
Nadine Renner, Alex B Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Boecking, Adolfo Saiardi, Eric O Freed, Leo C James
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nature structural & molecular biology 30 (3) (2023)
Nadine Renner, Alex B Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Boecking, Adolfo Saiardi, Eric O Freed, Leo C James
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nature structural & molecular biology (2023)
Nadine Renner, Alex B Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Boecking, Adolfo Saiardi, Eric O Freed, Leo C James
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nature structural & molecular biology 30 (3) (2023)
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri Aastedatter Sakya, Sophie A I Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Christopher Green, Lise R Skov, Sanne Simone Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James Benedict Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models. Science (New York, N.Y.) 379 (6639) (2023)
Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C James
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates. Nature communications 14 (1) (2023)
Nadine Renner, Alex B Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Boecking, Adolfo Saiardi, Eric O Freed, Leo C James
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nature structural & molecular biology 30 (3) (2023)
Nadine Renner, Alex B Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Boecking, Adolfo Saiardi, Eric O Freed, Leo C James
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nature structural & molecular biology (2023)
Nadine Renner, Alex B Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Boecking, Adolfo Saiardi, Eric O Freed, Leo C James
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nature structural & molecular biology (2023)
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri Aastedatter Sakya, Sophie A I Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Christopher Green, Lise R Skov, Sanne Simone Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James Benedict Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models. Science (New York, N.Y.) 379 (6639) (2023)
Nadine Renner, Alex B Kleinpeter, Donna L Mallery, Anna Albecka, K M Rifat Faysal, Till Boecking, Adolfo Saiardi, Eric O Freed, Leo C James
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly. Nature structural & molecular biology (2023)
Katherine U Gaynor, Marina Vaysburd, Maximilian A J Harman, Anna Albecka, Phillip Jeffrey, Paul Beswick, Guido Papa, Liuhong Chen, Donna L Mallery, Brian McGuinness, Katerine Van Rietschoten, Steven Stanway, Paul D Brear, Aleksei Lulla, Katarzyna A Ciazynska, Veronica T Chang, Joanne Sharp, Megan Neary, Helen Box, Jo Herriott, Edyta Kijak, Lee Tatham, Eleanor G Bentley, Parul Sharma, Adam Kirby, Ximeng Han, James P Stewart, Andrew Owen, John A G Briggs, Marko Hyvönen, Michael J Skynner, Leo C James
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2. Nature communications 14 (1) (2023)
Alice Fletcher, Dean Clift, Emma de Vries, Sergio Martinez Cuesta, Timothy Malcolm, Francesco Meghini, Raghothama Chaerkady, Junmin Wang, Abby Chiang, Shao Huan Samuel Weng, Jonathan Tart, Edmond Wong, Gerard Donohoe, Philip Rawlins, Euan Gordon, Jonathan D Taylor, Leo C James, James Hunt
A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation. Nature communications 14 (1) (2023)
Lorena Zuliani-Alvarez, Morten L Govasli, Jane Rasaiyaah, Chris Monit, Stephen O Perry, Rebecca P Sumner, Simon McAlpine-Scott, Claire F Dickson, K M Rifat Faysal, Laura Hilditch, Richard J Miles, Frederic Bibollet-Ruche, Beatrice H Hahn, Till Boecking, Nikos Pinotsis, Leo C James, David A Jacques, Greg J Towers
Evasion of cGAS and TRIM5 defines pandemic HIV. Nature microbiology 7 (11) (2022)
Stian Foss, Alexandra Jonsson, Maria Bottermann, Ruth Elizabeth Watkinson, Heidrun E Lode, Martin B McAdam, Terje E Michaelsen, Inger Sandlie, Leo C James, Jan Terje Andersen
Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge. Science immunology 7 (70) (2022)
Jérôme Cattin-Ortolá, Lawrence G Welch, Sarah L Maslen, Guido Papa, Leo C James, Sean Munro
Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation. Nature communications 12 (1) (2021)
Jingwei Zeng, Ana Filipa Santos, Aamir S Mukadam, Mariana Osswald, David A Jacques, Claire F Dickson, Stephen H McLaughlin, Christopher M Johnson, Leo Kiss, Jakub Luptak, Nadine Renner, Marina Vaysburd, William A McEwan, Eurico Morais-de-Sá, Dean Clift, Leo C James
Target-induced clustering activates Trim-Away of pathogens and proteins. Nature structural & molecular biology 28 (3) (2021)
Ralf Salzer, Jordan J Clark, Marina Vaysburd, Veronica T Chang, Anna Albecka, Leo Kiss, Parul Sharma, Andres Gonzalez Llamazares, Anja Kipar, Julian A Hiscox, Andrew Owen, A Radu Aricescu, James P Stewart, Leo C James, Jan Löwe
Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice. FEBS letters 595 (18) (2021)
Leo Kiss, Dean Clift, Nadine Renner, David Neuhaus, Leo C James
RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination. Nature communications 12 (1) (2021)
Guido Papa, Donna L Mallery, Anna Albecka, Lawrence G Welch, Jérôme Cattin-Ortolá, Jakub Luptak, David Paul, Harvey T McMahon, Ian G Goodfellow, Andrew P Carter, Sean Munro, Leo C James
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion. PLoS pathogens 17 (1) (2021)
Anna Albecka, Dean Clift, Marina Vaysburd, Tyler Rhinesmith, Sarah L Caddy, David M Favara, Helen E Baxendale, Leo C James
A functional assay for serum detection of antibodies against SARS-CoV-2 nucleoprotein. The EMBO journal 40 (17) (2021)
Nadine Renner, Donna L Mallery, K M Rifat Faysal, Wang Peng, David A Jacques, Till Boecking, Leo C James
A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly. PLoS pathogens 17 (2) (2021)
Donna L Mallery, Alex B Kleinpeter, Nadine Renner, K M Rifat Faysal, Mariia Novikova, Leo Kiss, Miranda S C Wilson, Bilal Ahsan, Zunlong Ke, John A G Briggs, Adolfo Saiardi, Till Boecking, Eric O Freed, Leo C James
A stable immature lattice packages IP6 for HIV capsid maturation. Science advances 7 (11) (2021)
Jingwei Zeng, Leo C James
Intracellular antibody immunity and its applications. PLoS pathogens 16 (8) (2020)
Sarah L Caddy, Marina Vaysburd, Mark Wing, Stian Foss, Jan Terje Andersen, Kevin O'Connell, Keith Mayes, Katie Higginson, Miren Iturriza-Gomara, Ulrich Desselberger, Leo C James
Intracellular neutralisation of rotavirus by VP6-specific IgG. PLoS pathogens 16 (8) (2020)
Sarah L Caddy, Marina Vaysburd, Guido Papa, Mark Wing, Kevin O'Connell, Diana Stoycheva, Stian Foss, Jan Terje Andersen, Annette Oxenius, Leo C James
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity. The EMBO journal 40 (5) (2020)
Larisa I Labzin, Maria Bottermann, Pablo Rodriguez-Silvestre, Stian Foss, Jan Terje Andersen, Marina Vaysburd, Dean Clift, Leo C James
Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. The EMBO journal 38 (21) (2019)
Jingwei Zeng, Greg Slodkowicz, Leo C James
Rare missense variants in the human cytosolic antibody receptor preserve antiviral function. eLife 8 (2019)
Donna L Mallery, Chantal L Márquez, William A McEwan, Claire F Dickson, David A Jacques, Madhanagopal Anandapadamanaban, Katsiaryna Bichel, Gregory J Towers, Adolfo Saiardi, Till Boecking, Leo C James
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. eLife 7 (2018)
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James
Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. eLife 7 (2018)