Reuben Stewart Harris (Reuben Harris, Reuben S Harris, R S Harris)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 74

Top Topics

Epstein Barr Virus

Top Venues

bioRxiv : the preprint server for biology

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Takafumi Shichijo, Jun-Ichirou Yasunaga, Kei Sato, Kisato Nosaka, Kosuke Toyoda, Miho Watanabe, Wenyi Zhang, Yoshio Koyanagi, Edward L Murphy, Roberta L Bruhn, Ki-Ryang Koh, Hirofumi Akari, Terumasa Ikeda, Reuben Stewart Harris, Patrick L Green, Masao Matsuoka
Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses. Proceedings of the National Academy of Sciences of the United States of America 121 (13) (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Nicola J Smith, Ian Reddin, Paige Policelli, Sunwoo Oh, Nur Zainal, Emma Howes, Benjamin Jenkins, Ian Tracy, Mark Edmond, Benjamin P Sharpe, Damian Amendra, Ke Zheng, Nagayasu Egawa, John Doorbar, Anjali Rao, Sangeetha Mahadevan, Michael A Carpenter, Reuben Stewart Harris, Simak Ali, Christopher J Hanley, Rémi Buisson, Emma King, Gareth J Thomas, Tim R Fenton
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma. Research square (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Takafumi Shichijo, Jun-Ichirou Yasunaga, Kei Sato, Kisato Nosaka, Kosuke Toyoda, Miho Watanabe, Wenyi Zhang, Yoshio Koyanagi, Edward L Murphy, Roberta L Bruhn, Ki-Ryang Koh, Hirofumi Akari, Terumasa Ikeda, Reuben Stewart Harris, Patrick L Green, Masao Matsuoka
Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses. Proceedings of the National Academy of Sciences of the United States of America 121 (13) (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Lulu Yin, Ke Shi, Yanjun Chen, Reuben Stewart Harris, Hideki Aihara
Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA. bioRxiv : the preprint server for biology (2024)
Nicola Smith, Ian Reddin, Paige Policelli, Sunwoo Oh, Rémi Buisson, Nur Zainal, Emma Howes, Benjamin Jenkins, Ian Tracy, Benjamin P Sharpe, Damian Amendra, Christopher J Hanley, Emma King, Gareth J Thomas, Mark Edmond, Simak Ali, Ke Zheng, Nagayasau Egawa, John Doorbar, Michael Carpenter, Reuben Stewart Harris, Anjali Rao, Sangeetha Mahadevan, Tim R Fenton
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma. Research square (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Christopher A Belica, Michael A Carpenter, Yanjun Chen, William L Brown, Nicholas H Moeller, Ian T Boylan, Reuben Stewart Harris, Hideki Aihara
A real-time biochemical assay for quantitative analyses of APOBEC-catalyzed DNA deamination. bioRxiv : the preprint server for biology (2024)
Takafumi Shichijo, Jun-Ichirou Yasunaga, Kei Sato, Kisato Nosaka, Kosuke Toyoda, Miho Watanabe, Wenyi Zhang, Yoshio Koyanagi, Edward L Murphy, Roberta L Bruhn, Ki-Ryang Koh, Hirofumi Akari, Terumasa Ikeda, Reuben Stewart Harris, Patrick L Green, Masao Matsuoka
Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses. Proceedings of the National Academy of Sciences of the United States of America 121 (13) (2024)
Takafumi Shichijo, Jun-Ichirou Yasunaga, Kei Sato, Kisato Nosaka, Kosuke Toyoda, Miho Watanabe, Wenyi Zhang, Yoshio Koyanagi, Edward L Murphy, Roberta L Bruhn, Ki-Ryang Koh, Hirofumi Akari, Terumasa Ikeda, Reuben Stewart Harris, Patrick L Green, Masao Matsuoka
Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses. Proceedings of the National Academy of Sciences of the United States of America 121 (13) (2024)
Nicola Smith, Ian Reddin, Paige Policelli, Sunwoo Oh, Rémi Buisson, Nur Zainal, Emma Howes, Benjamin Jenkins, Ian Tracy, Benjamin P Sharpe, Damian Amendra, Christopher J Hanley, Emma King, Gareth J Thomas, Mark Edmond, Simak Ali, Ke Zheng, Nagayasau Egawa, John Doorbar, Michael Carpenter, Reuben Stewart Harris, Anjali Rao, Sangeetha Mahadevan, Tim R Fenton
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma. Research square (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Jennifer L McCann, Agnese Cristini, Emily K Law, Seo Yun Lee, Michael Tellier, Michael A Carpenter, Chiara Beghè, Jae Jin Kim, Anthony R Sanchez, Matthew C Jarvis, Bojana Stefanovska, Nuri Alpay Temiz, Erik N Bergstrom, Daniel J Salamango, Margaret R Brown, Shona Murphy, Ludmil B Alexandrov, Kyle M Miller, Natalia Gromak, Reuben Stewart Harris
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer. Nature genetics (2023)
Michael A Carpenter, Nuri A Temiz, Mahmoud A Ibrahim, Matthew C Jarvis, Margaret R Brown, Prokopios P Argyris, William L Brown, Gabriel J Starrett, Douglas Yee, Reuben Stewart Harris
Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer. PLoS genetics 19 (11) (2023)
Stefan Harjes, Harikrishnan M Kurup, Amanda E Rieffer, Maitsetseg Bayarjargal, Jana Filitcheva, Yongdong Su, Tracy K Hale, Vyacheslav V Filichev, Elena Harjes, Reuben Stewart Harris, Geoffrey B Jameson
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. bioRxiv : the preprint server for biology (2023)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes. bioRxiv : the preprint server for biology (2023)
Amanda E Rieffer, Yanjun Chen, Daniel J Salamango, Sofia N Moraes, Reuben Stewart Harris
APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels. The CRISPR journal (2023)
Stefan Harjes, Harikrishnan M Kurup, Amanda E Rieffer, Maitsetseg Bayarjargal, Jana Filitcheva, Yongdong Su, Tracy K Hale, Vyacheslav V Filichev, Elena Harjes, Reuben Stewart Harris, Geoffrey B Jameson
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. bioRxiv : the preprint server for biology (2023)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Pieter A Roelofs, Mieke A M Timmermans, Bojana Stefanovska, Myrthe A den Boestert, Amber W M van den Borne, Hayri E Balcioglu, Anita M Trapman, Reuben Stewart Harris, John W M Martens, Paul N Span
Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase. Cells 12 (8) (2023)
Elisa Fanunza, Adam Z Cheng, Ashley A Auerbach, Bojana Stefanovska, Sofia N Moraes, James R Lokensgard, Matteo Biolatti, Valentina Dell'Oste, Craig J Bierle, Wade A Bresnahan, Reuben Stewart Harris
Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism. Journal of virology (2023)
Francesco Costacurta, Andrea Dodaro, David Bante, Helge Schoeppe, Bernhard Sprenger, Seyed Arad Moghadasi, Jakob Fleischmann, Matteo Pavan, Davide Bassani, Silvia Menin, Stefanie Rauch, Laura Krismer, Anna Sauerwein, Anne Heberle, Toni Rabensteiner, Joses Wei Hao Ho, Reuben Stewart Harris, Eduard Stefan, Rainer Schneider, Teresa Kaserer, Stefano Moro, Dorothee von Laer, Emmanuel Heilmann
A comprehensive study of SARS-CoV-2 main protease (M pro ) inhibitor-resistant mutants selected in a VSV-based system. bioRxiv : the preprint server for biology (2023)
Cameron Durfee, Nuri Alpay Temiz, Rena Levin-Klein, Prokopios P Argyris, Lene Alsøe, Sergio Carracedo, Alicia Alonso de la Vega, Joshua Proehl, Anna M Holzhauer, Zachary J Seeman, Yu-Hsiu T Lin, Rachel I Vogel, Rocio Sotillo, Hilde Loge Nilsen, Reuben Stewart Harris
Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases. bioRxiv : the preprint server for biology (2023)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Terumasa Ikeda, Ryo Shimizu, Hesham Nasser, Michael A Carpenter, Adam Z Cheng, William L Brown, Daniel Sauter, Reuben Stewart Harris
APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1. bioRxiv : the preprint server for biology (2023)
Elisa Fanunza, Adam Z Cheng, Ashley A Auerbach, Bojana Stefanovska, Sofia N Moraes, James R Lokensgard, Matteo Biolatti, Valentina Dellâ Oste, Craig J Bierle, Wade A Bresnahan, Reuben Stewart Harris
Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism. bioRxiv : the preprint server for biology (2023)
Pieter A Roelofs, Mieke A M Timmermans, Bojana Stefanovska, Myrthe A den Boestert, Amber W M van den Borne, Hayri E Balcioglu, Anita M Trapman, Reuben Stewart Harris, John W M Martens, Paul N Span
Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase. Cells 12 (8) (2023)
Gabriel J Starrett, Kelly Yu, Yelena Golubeva, Petra Lenz, Mary L Piaskowski, David Petersen, Michael Dean, Ajay Israni, Brenda Y Hernandez, Thomas C Tucker, Iona Cheng, Lou Gonsalves, Cyllene R Morris, Shehnaz K Hussain, Charles F Lynch, Reuben Stewart Harris, Ludmila Prokunina-Olsson, Paul S Meltzer, Christopher B Buck, Eric A Engels
Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients. eLife 12 (2023)
Cameron Durfee, Nuri Alpay Temiz, Rena Levin-Klein, Prokopios P Argyris, Lene Alsøe, Sergio Carracedo, Alicia Alonso de la Vega, Joshua Proehl, Anna M Holzhauer, Zachary J Seeman, Yu-Hsiu T Lin, Rachel I Vogel, Rocio Sotillo, Hilde Loge Nilsen, Reuben Stewart Harris
Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases. bioRxiv : the preprint server for biology (2023)
Seyed Arad Moghadasi, Rayhan G Biswas, Daniel A Harki, Reuben Stewart Harris
Rapid resistance profiling of SARS-CoV-2 protease inhibitors. bioRxiv : the preprint server for biology (2023)
Stefan Harjes, Harikrishnan M Kurup, Amanda E Rieffer, Maitsetseg Bayarjargal, Jana Filitcheva, Yongdong Su, Tracy K Hale, Vyacheslav V Filichev, Elena Harjes, Reuben Stewart Harris, Geoffrey B Jameson
Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nature communications 14 (1) (2023)
Cameron Durfee, Nuri Alpay Temiz, Rena Levin-Klein, Prokopios P Argyris, Lene Alsøe, Sergio Carracedo, Alicia Alonso de la Vega, Joshua Proehl, Anna M Holzhauer, Zachary J Seeman, Yu-Hsiu T Lin, Rachel I Vogel, Rocio Sotillo, Hilde Loge Nilsen, Reuben Stewart Harris
Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases. bioRxiv : the preprint server for biology (2023)
Elisa Fanunza, Adam Z Cheng, Ashley A Auerbach, Bojana Stefanovska, Sofia N Moraes, James R Lokensgard, Matteo Biolatti, Valentina Dellâ Oste, Craig J Bierle, Wade A Bresnahan, Reuben Stewart Harris
Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism. bioRxiv : the preprint server for biology (2023)
Elisa Fanunza, Adam Z Cheng, Ashley A Auerbach, Bojana Stefanovska, Sofia N Moraes, James R Lokensgard, Matteo Biolatti, Valentina Dellâ Oste, Craig J Bierle, Wade A Bresnahan, Reuben Stewart Harris
Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism. bioRxiv : the preprint server for biology (2023)
Deborah R Caswell, Philippe Gui, Manasi K Mayekar, Emily K Law, Oriol Pich, Chris Bailey, Jesse Boumelha, D Lucas Kerr, Collin M Blakely, Tadashi Manabe, Carlos Martinez-Ruiz, Bjorn Bakker, Juan De Dios Palomino Villcas, Natalie I Vokes, Michelle Dietzen, Mihaela Angelova, Beatrice Gini, Whitney Tamaki, Paul Allegakoen, Wei Wu, Timothy J Humpton, William Hill, Mona Tomaschko, Wei-Ting Lu, Franziska Haderk, Maise Al Bakir, Ai Nagano, Francisco Gimeno-Valiente, Sophie de Carné Trécesson, Roberto Vendramin, Vittorio Barbè, Miriam Mugabo, Clare E Weeden, Andrew Rowan, Caroline E McCoach, Bruna Almeida, Mary Green, Carlos Gomez, Shigeki Nanjo, Dora Barbosa, Chris Moore, Joanna Przewrocka, James R M Black, Eva Grönroos, Alejandro Suarez-Bonnet, Simon Lawrence Priestnall, Caroline Zverev, Scott Lighterness, James Cormack, Victor Olivas, Lauren Cech, Trisha Andrews, Brandon Rule, Yuwei Jiao, Xinzhu Zhang, Paul Ashford, Cameron Durfee, Subramanian Venkatesan, Nuri Alpay Temiz, Lisa Tan, Lindsay K Larson, Prokopios P Argyris, William L Brown, Elizabeth A Yu, Julia K Rotow, Udayan Guha, Nitin Roper, Johnny Yu, Rachel Isaksson Vogel, Nicholas J Thomas, Antonio Marra, Pier Selenica, Helena Alexandra Yu, Samuel F Bakhoum, Su Kit Chew, Jorge Sergio Reis-Filho, Mariam Jamal-Hanjani, Karen H Vousden, Nicholas McGranahan, Eliezer Van Allen, Nnennaya Kanu, Reuben Stewart Harris, Julian Downward, Trever G Bivona, Charles Swanton
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance. Nature genetics (2023)
Terumasa Ikeda, Ryo Shimizu, Hesham Nasser, Michael A Carpenter, Adam Z Cheng, William L Brown, Daniel Sauter, Reuben Stewart Harris
APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1. mBio (2023)
Seyed Arad Moghadasi, Rayhan G Biswas, Daniel A Harki, Reuben Stewart Harris
Rapid resistance profiling of SARS-CoV-2 protease inhibitors. bioRxiv : the preprint server for biology (2023)
Pieter A Roelofs, Mieke A M Timmermans, Bojana Stefanovska, Myrthe A den Boestert, Amber W M van den Borne, Hayri E Balcioglu, Anita M Trapman, Reuben Stewart Harris, John W M Martens, Paul N Span
Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase. Cells 12 (8) (2023)
Reuben Stewart Harris, Seyed Moghadasi, Rayhan G Biswas, Daniel A Harki
Rapid resistance profiling of SARS-CoV-2 protease inhibitors. Research square (2023)
Seyed Arad Moghadasi, Emmanuel Heilmann, Ahmed Magdy Khalil, Christina Nnabuife, Fiona L Kearns, Chengjin Ye, Sofia N Moraes, Francesco Costacurta, Morgan A Esler, Hideki Aihara, Dorothee von Laer, Luis Martinez-Sobrido, Timothy G Palzkill, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Science advances 9 (13) (2023)
Jesse Boumelha, Sophie de Carné Trécesson, Emily K Law, Pablo Romero-Clavijo, Matthew A Coelho, Kevin W Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R Caswell, Miguel Murillo, David C Hancock, Prokopios P Argyris, William L Brown, Cameron Durfee, Lindsay K Larson, Rachel Isaksson Vogel, Alejandro Suarez-Bonnet, Simon Lawrence Priestnall, Philip East, Sarah J Ross, George Kassiotis, Miriam Molina-Arcas, Charles Swanton, Reuben Stewart Harris, Julian Downward
An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations. Cancer research 82 (19) (2022)
Seyed Arad Moghadasi, Emmanuel Heilmann, Sofia N Moraes, Fiona L Kearns, Dorothee von Laer, Rommie Elizabeth Amaro, Reuben Stewart Harris
Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. bioRxiv : the preprint server for biology (2022)
Jaime Yockteng-Melgar, Kathy Shire, Adam Z Cheng, Natasha Malik-Soni, Reuben Stewart Harris, Lori Frappier
G 1 /S Cell Cycle Induction by Epstein-Barr Virus BORF2 Is Mediated by P53 and APOBEC3B. Journal of virology 96 (18) (2022)
Erik N Bergstrom, Jens Luebeck, Mia Petljak, Azhar Khandekar, Mark Barnes, Tongwu Zhang, Christopher D Steele, Nischalan Pillay, Maria Teresa Landi, Vineet Bafna, Paul S Mischel, Reuben Stewart Harris, Ludmil B Alexandrov
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. Nature 602 (7897) (2022)
Nadine M Shaban, Rui Yan, Ke Shi, Sofia N Moraes, Adam Z Cheng, Michael A Carpenter, Jason S Mclellan, Zhiheng Yu, Reuben Stewart Harris
Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition. Science advances 8 (17) (2022)
Emmanuel Heilmann, Francesco Costacurta, Stephan Geley, Seyad Arad Mogadashi, Andre Volland, Bernhard Rupp, Reuben Stewart Harris, Dorothee von Laer
A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition. Communications biology 5 (1) (2022)
Emmanuel Heilmann, Francesco Costacurta, Seyed Arad Moghadasi, Chengjin Ye, Matteo Pavan, Davide Bassani, André Volland, Claudia Ascher, Alexander Kurt Hermann Weiss, David Bante, Reuben Stewart Harris, Stefano Moro, Bernhard Rupp, Luis Martinez-Sobrido, Dorothee von Laer
SARS-CoV-2 3CL pro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376. Science translational medicine (2022)
Sofia N Moraes, Jordan T Becker, Seyed Arad Moghadasi, Nadine M Shaban, Ashley A Auerbach, Adam Z Cheng, Reuben Stewart Harris
Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases. eLife 11 (2022)
Ashley A Auerbach, Jordan T Becker, Sofia N Moraes, Seyed Arad Moghadasi, Jolene M Duda, Daniel J Salamango, Reuben Stewart Harris
Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species. mSphere (2022)
Pieter A Roelofs, John W M Martens, Reuben Stewart Harris, Paul N Span
Clinical Implications of APOBEC3-mediated Mutagenesis in Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Seyed Arad Moghadasi, Morgan A Esler, Yuka Otsuka, Jordan T Becker, Sofia N Moraes, Constance B Anderson, Srinivas Chamakuri, Christopher Belica, Chloe Wick, Daniel A Harki, Damian W Young, Louis Scampavia, Timothy P Spicer, Ke Shi, Hideki Aihara, William L Brown, Reuben Stewart Harris
Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M pro /3CL pro in Living Cells. mBio 13 (3) (2022)
Simon C Baker, Andrew S Mason, Raphael G Slip, Katie T Skinner, Andrew Macdonald, Omar Masood, Reuben Stewart Harris, Tim R Fenton, Manikandan Periyasamy, Simak Ali, Jennifer Southgate
Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer. Oncogene 41 (15) (2022)
Sonja M Wörmann, Amy Zhang, Fredrik I Thege, Robert W Cowan, Dhwani N Rupani, Runsheng Wang, Sara L Manning, Chris Gates, Weisheng Wu, Rena Levin-Klein, Kimal I Rajapakshe, Meifang Yu, Asha S Multani, Ya'an Kang, Cullen M Taniguchi, Katharina Schlacher, Melena D Bellin, Matthew H G Katz, Michael P Kim, Jason B Fleming, Steven Gallinger, Ravikanth Maddipati, Reuben Stewart Harris, Faiyaz Notta, Susan R Ross, Anirban Maitra, Andrew D Rhim
APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis. Nature cancer 2 (12) (2021)
Ke Shi, Nicholas H Moeller, Surajit Banerjee, Jennifer L McCann, Michael A Carpenter, Lulu Yin, Ramkumar Moorthy, Kayo Orellana, Daniel A Harki, Reuben Stewart Harris, Hideki Aihara
Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q. Proceedings of the National Academy of Sciences of the United States of America 118 (10) (2021)
Prokopios P Argyris, Peter E Wilkinson, Matthew C Jarvis, Kelly R Magliocca, Mihir R Patel, Rachel I Vogel, Rajaram Gopalakrishnan, Ioannis G Koutlas, Reuben Stewart Harris
Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 34 (2) (2020)
Pieter A Roelofs, Chai Yeen Goh, Boon Haow Chua, Matthew C Jarvis, Teneale A Stewart, Jennifer L McCann, Rebecca M McDougle, Michael A Carpenter, John W M Martens, Paul N Span, Dennis Kappei, Reuben Stewart Harris
Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B. eLife 9 (2020)
Yusuke Nakano, Keisuke Yamamoto, Mahoko Takahashi Ueda, Andrew Soper, Yoriyuki Konno, Izumi Kimura, Keiya Uriu, Ryuichi Kumata, Hirofumi Aso, Naoko Misawa, Shumpei Nagaoka, Soma Shimizu, Keito Mitsumune, Yusuke Kosugi, Guillermo Juarez-Fernandez, Jumpei Ito, So Nakagawa, Terumasa Ikeda, Yoshio Koyanagi, Reuben Stewart Harris, Kei Sato
A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. PLoS pathogens 16 (9) (2020)
Daniel J Salamango, Jennifer L McCann, Özlem Demir, Jordan T Becker, Jiayi Wang, Jairam R Lingappa, Nuri A Temiz, William L Brown, Rommie E Amaro, Reuben Stewart Harris
Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling. Journal of virology 94 (21) (2020)
Seyad Arad Moghadasi, Jordan T Becker, Christopher Belica, Chloe Wick, William L Brown, Reuben Stewart Harris
Gain-of-function assay for SARS-CoV-2 M pro inhibition in living cells. bioRxiv : the preprint server for biology (2020)
Veer Bhatt, Ke Shi, Daniel J Salamango, Nicholas H Moeller, Krishan K Pandey, Sibes Bera, Heather O Bohl, Fredy Kurniawan, Kayo Orellana, Wei Zhang, Duane P Grandgenett, Reuben Stewart Harris, Anna C Sundborger-Lunna, Hideki Aihara
Structural basis of host protein hijacking in human T-cell leukemia virus integration. Nature communications 11 (1) (2020)
Christopher B Driscoll, Matthew R Schuelke, Timothy Kottke, Jill M Thompson, Phonphimon Wongthida, Jason M Tonne, Amanda L Huff, Amber Miller, Kevin G Shim, Amy Molan, Cynthia Wetmore, Peter Selby, Adel Samson, Kevin Harrington, Hardev Pandha, Alan Melcher, Jose S Pulido, Reuben Stewart Harris, Laura Evgin, Richard G Vile
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy. Nature communications 11 (1) (2020)
Jennifer L McCann, Daniel J Salamango, Emily K Law, William L Brown, Reuben Stewart Harris
MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets. Life science alliance 3 (4) (2020)
Artur A Serebrenik, Gabriel J Starrett, Sterre Leenen, Matthew C Jarvis, Nadine M Shaban, Daniel J Salamango, Hilde Nilsen, William L Brown, Reuben Stewart Harris
The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America 116 (44) (2019)
Adam Z Cheng, Sofia N Moraes, Claire Attarian, Jaime Yockteng-Melgar, Matthew C Jarvis, Matteo Biolatti, Ganna Galitska, Valentina Dell'Oste, Lori Frappier, Craig J Bierle, Stephen A Rice, Reuben Stewart Harris
A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits. Journal of virology 93 (23) (2019)
A St Martin, D J Salamango, A A Serebrenik, N M Shaban, W L Brown, Reuben Stewart Harris
A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes. Scientific reports 9 (1) (2019)
Brett D Anderson, Terumasa Ikeda, Seyed Arad Moghadasi, Amber St Martin, William L Brown, Reuben Stewart Harris
Natural APOBEC3C variants can elicit differential HIV-1 restriction activity. Retrovirology 15 (1) (2018)
Adam Z Cheng, Jaime Yockteng-Melgar, Matthew C Jarvis, Natasha Malik-Soni, Ivan Borozan, Michael A Carpenter, Jennifer L McCann, Diako Ebrahimi, Nadine M Shaban, Edyta Marcon, Jack Greenblatt, William L Brown, Lori Frappier, Reuben Stewart Harris
Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity. Nature microbiology 4 (1) (2018)
Terumasa Ikeda, Menelaos Symeonides, John S Albin, Ming Li, Markus Thali, Reuben Stewart Harris
HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G. PLoS pathogens 14 (4) (2018)