Xiaoli Xiong

ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 31

Top Venues

Nature communications

Nature microbiology

Research square

Signal transduction and targeted therapy

Guangzhou Institutes of Biomedicine and Health

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Guangzhou Institutes of Biomedicine and Health Sep 01 2020

China

Principal Investigator/Professor

MRC Laboratory of Molecular Biology May 01 2018 - Aug 31 2020

United Kingdom

Postdoctoral Scientist :: Structural Studies

University of Washington Oct 01 2016 - Apr 30 2018

United States

Senior Fellow :: Department of Biochemistry

The Francis Crick Institute Jan 01 2015 - Sep 30 2016

United Kingdom

Career Development Fellow

MRC National Institute for Medical Research Mar 01 2011 - Dec 31 2014

United Kingdom

Career Development Fellow :: Molecular Structure

Publications

Xiaoxin Chen, Xiaodong Huang, Qinhai Ma, Petr Kuzmič, Biao Zhou, Sai Zhang, Jizheng Chen, Jinxin Xu, Bin Liu, Haiming Jiang, Wenjie Zhang, Chunguang Yang, Shiguan Wu, Jianzhou Huang, Haijun Li, Chaofeng Long, Xin Zhao, Hongrui Xu, Yanan Sheng, Yaoting Guo, Chuanying Niu, Lu Xue, Yong Xu, Jin-Song Liu, Tian-Yu Zhang, James Spencer, Zhenzhen Zhu, Wenbing Deng, Xinwen Chen, Shu-Hui Chen, Nan-Shan Zhong, Xiaoli Xiong, Zi-Feng Yang
Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir. Nature microbiology 9 (4) (2024)
Xiaoxin Chen, Xiaodong Huang, Qinhai Ma, Petr Kuzmič, Biao Zhou, Sai Zhang, Jizheng Chen, Jinxin Xu, Bin Liu, Haiming Jiang, Wenjie Zhang, Chunguang Yang, Shiguan Wu, Jianzhou Huang, Haijun Li, Chaofeng Long, Xin Zhao, Hongrui Xu, Yanan Sheng, Yaoting Guo, Chuanying Niu, Lu Xue, Yong Xu, Jin-Song Liu, Tian-Yu Zhang, James Spencer, Zhenzhen Zhu, Wenbing Deng, Xinwen Chen, Shu-Hui Chen, Nan-Shan Zhong, Xiaoli Xiong, Zi-Feng Yang
Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir. Nature microbiology 9 (4) (2024)
Lu Xue, Tiancai Chang, Zimu Li, Chenchen Wang, Heyu Zhao, Mei Li, Peng Tang, Xin Wen, Mengmeng Yu, Jiqin Wu, Xichen Bao, Xiaojun Wang, Peng Gong, Jun He, Xinwen Chen, Xiaoli Xiong
Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses. Nature communications 15 (1) (2024)
Si Chen, Zhengyuan Zhang, Qian Wang, Qi Yang, Li Yin, Lishan Ning, Zhilong Chen, Jielin Tang, Weiqi Deng, Ping He, Hengchun Li, Linjing Shi, Yijun Deng, Zijian Liu, Hemeng Bu, Yaohui Zhu, Wenming Liu, Linbing Qu, Liqiang Feng, Xiaoli Xiong, Baoqing Sun, Nanshan Zhong, Feng Li, Pingchao Li, Xinwen Chen, Ling Chen
Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies. Signal transduction and targeted therapy 9 (1) (2024)
Si Chen, Zhengyuan Zhang, Qian Wang, Qi Yang, Li Yin, Lishan Ning, Zhilong Chen, Jielin Tang, Weiqi Deng, Ping He, Hengchun Li, Linjing Shi, Yijun Deng, Zijian Liu, Hemeng Bu, Yaohui Zhu, Wenming Liu, Linbing Qu, Liqiang Feng, Xiaoli Xiong, Baoqing Sun, Nanshan Zhong, Feng Li, Pingchao Li, Xinwen Chen, Ling Chen
Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies. Signal transduction and targeted therapy 9 (1) (2024)
Xiaoxin Chen, Xiaodong Huang, Qinhai Ma, Petr Kuzmič, Biao Zhou, Sai Zhang, Jizheng Chen, Jinxin Xu, Bin Liu, Haiming Jiang, Wenjie Zhang, Chunguang Yang, Shiguan Wu, Jianzhou Huang, Haijun Li, Chaofeng Long, Xin Zhao, Hongrui Xu, Yanan Sheng, Yaoting Guo, Chuanying Niu, Lu Xue, Yong Xu, Jin-Song Liu, Tian-Yu Zhang, James Spencer, Zhenzhen Zhu, Wenbing Deng, Xinwen Chen, Shu-Hui Chen, Nan-Shan Zhong, Xiaoli Xiong, Zi-Feng Yang
Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir. Nature microbiology 9 (4) (2024)
Qihong Yan, Xijie Gao, Banghui Liu, Ruitian Hou, Ping He, Yong Ma, Yudi Zhang, Yanjun Zhang, Zimu Li, Qiuluan Chen, Jingjing Wang, Xiaohan Huang, Huan Liang, Huiran Zheng, Yichen Yao, Xianying Chen, Xuefeng Niu, Jun He, Ling Chen, Jin-Cun Zhao, Xiaoli Xiong
Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants. Nature communications 15 (1) (2024)
Xiaoxin Chen, Xiaodong Huang, Qinhai Ma, Petr Kuzmič, Biao Zhou, Sai Zhang, Jizheng Chen, Jinxin Xu, Bin Liu, Haiming Jiang, Wenjie Zhang, Chunguang Yang, Shiguan Wu, Jianzhou Huang, Haijun Li, Chaofeng Long, Xin Zhao, Hongrui Xu, Yanan Sheng, Yaoting Guo, Chuanying Niu, Lu Xue, Yong Xu, Jin-Song Liu, Tian-Yu Zhang, James Spencer, Zhenzhen Zhu, Wenbing Deng, Xinwen Chen, Shu-Hui Chen, Nan-Shan Zhong, Xiaoli Xiong, Zi-Feng Yang
Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir. Nature microbiology 9 (4) (2024)
Xiaoxin Chen, Xiaodong Huang, Qinhai Ma, Petr Kuzmič, Biao Zhou, Sai Zhang, Jizheng Chen, Jinxin Xu, Bin Liu, Haiming Jiang, Wenjie Zhang, Chunguang Yang, Shiguan Wu, Jianzhou Huang, Haijun Li, Chaofeng Long, Xin Zhao, Hongrui Xu, Yanan Sheng, Yaoting Guo, Chuanying Niu, Lu Xue, Yong Xu, Jin-Song Liu, Tian-Yu Zhang, James Spencer, Zhenzhen Zhu, Wenbing Deng, Xinwen Chen, Shu-Hui Chen, Nan-Shan Zhong, Xiaoli Xiong, Zi-Feng Yang
Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir. Nature microbiology 9 (4) (2024)
Si Chen, Zhengyuan Zhang, Qian Wang, Qi Yang, Li Yin, Lishan Ning, Zhilong Chen, Jielin Tang, Weiqi Deng, Ping He, Hengchun Li, Linjing Shi, Yijun Deng, Zijian Liu, Hemeng Bu, Yaohui Zhu, Wenming Liu, Linbing Qu, Liqiang Feng, Xiaoli Xiong, Baoqing Sun, Nanshan Zhong, Feng Li, Pingchao Li, Xinwen Chen, Ling Chen
Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies. Signal transduction and targeted therapy 9 (1) (2024)
Xiaoxin Chen, Xiaodong Huang, Qinhai Ma, Petr Kuzmič, Biao Zhou, Sai Zhang, Jizheng Chen, Jinxin Xu, Bin Liu, Haiming Jiang, Wenjie Zhang, Chunguang Yang, Shiguan Wu, Jianzhou Huang, Haijun Li, Chaofeng Long, Xin Zhao, Hongrui Xu, Yanan Sheng, Yaoting Guo, Chuanying Niu, Lu Xue, Yong Xu, Jin-Song Liu, Tian-Yu Zhang, James Spencer, Zhenzhen Zhu, Wenbing Deng, Xinwen Chen, Shu-Hui Chen, Nan-Shan Zhong, Xiaoli Xiong, Zi-Feng Yang
Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir. Nature microbiology (2024)
Qihong Yan, Xijie Gao, Banghui Liu, Ruitian Hou, Ping He, Yong Ma, Yudi Zhang, Yanjun Zhang, Zimu Li, Qiuluan Chen, Jingjing Wang, Xiaohan Huang, Huan Liang, Huiran Zheng, Yichen Yao, Xianying Chen, Xuefeng Niu, Jun He, Ling Chen, Jin-Cun Zhao, Xiaoli Xiong
Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants. Nature communications 15 (1) (2024)
Lu Xue, Tiancai Chang, Zimu Li, Chenchen Wang, Heyu Zhao, Mei Li, Peng Tang, Xin Wen, Mengmeng Yu, Jiqin Wu, Xichen Bao, Xiaojun Wang, Peng Gong, Jun He, Xinwen Chen, Xiaoli Xiong
Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses. Nature communications 15 (1) (2024)
Lu Xue, Tiancai Chang, Zimu Li, Chenchen Wang, Heyu Zhao, Mei Li, Peng Tang, Xin Wen, Mengmeng Yu, Jiqin Wu, Xichen Bao, Xiaojun Wang, Peng Gong, Jun He, Xinwen Chen, Xiaoli Xiong
Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses. Nature communications 15 (1) (2024)
Erica Ollmann Saphire, Zhe Li Salie, Zunlong Ke, Peter J Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon L Schendel, Chitra Hariharan, Michael Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael R Holbrook, Benjamin J Doranz, Ian Crozier, Kathryn Hastie, Yoshihiro Kawaoka, Luis Branco, J Thomas Beatty, John Briggs, Gabriella Worwa, Carl Davis, Rajesh M Valanparambil
Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane. Research square (2023)
Erica Ollmann Saphire, Zhe Li Salie, Zunlong Ke, Peter J Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon L Schendel, Chitra Hariharan, Michael Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael R Holbrook, Benjamin J Doranz, Ian Crozier, Kathryn Hastie, Yoshihiro Kawaoka, Luis Branco, J Thomas Beatty, John Briggs, Gabriella Worwa, Carl Davis, Rajesh M Valanparambil
Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane. Research square (2023)
Erica Ollmann Saphire, Zhe Li Salie, Zunlong Ke, Peter J Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon L Schendel, Chitra Hariharan, Michael Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael R Holbrook, Benjamin J Doranz, Ian Crozier, Kathryn Hastie, Yoshihiro Kawaoka, Luis Branco, J Thomas Beatty, John Briggs, Gabriella Worwa, Carl Davis, Rajesh M Valanparambil
Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane. Research square (2023)
Erica Ollmann Saphire, Zhe Li Salie, Zunlong Ke, Peter J Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon L Schendel, Chitra Hariharan, Michael Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael R Holbrook, Benjamin J Doranz, Ian Crozier, Kathryn Hastie, Yoshihiro Kawaoka, Luis Branco, J Thomas Beatty, John Briggs, Gabriella Worwa, Carl Davis, Rajesh M Valanparambil
Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane. Research square (2023)
Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants. Nature communications 14 (1) (2023)
Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants. Nature communications 14 (1) (2023)
Erica Ollmann Saphire, Zhe Li Salie, Zunlong Ke, Peter J Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon L Schendel, Chitra Hariharan, Michael Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael R Holbrook, Benjamin J Doranz, Ian Crozier, Kathryn Hastie, Yoshihiro Kawaoka, Luis Branco, J Thomas Beatty, John Briggs, Gabriella Worwa, Carl Davis, Rajesh M Valanparambil
Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane. Research square (2023)
Xixi Zhang, Zimu Li, Yanjun Zhang, Yutong Liu, Jingjing Wang, Banghui Liu, Qiuluan Chen, Qian Wang, Lutang Fu, Peiyi Wang, Xiaolin Zhong, Liang Jin, Qihong Yan, Ling Chen, Jun He, Jincun Zhao, Xiaoli Xiong
Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Life science alliance 6 (9) (2023)
Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants. Nature communications 14 (1) (2023)
Erica Ollmann Saphire, Zhe Li Salie, Zunlong Ke, Peter J Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon L Schendel, Chitra Hariharan, Michael Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael R Holbrook, Benjamin J Doranz, Ian Crozier, Kathryn Hastie, Yoshihiro Kawaoka, Luis Branco, J Thomas Beatty, John Briggs, Gabriella Worwa, Carl Davis, Rajesh M Valanparambil
Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane. Research square (2023)
Ping He, Banghui Liu, Xijie Gao, Qihong Yan, Rongjuan Pei, Jing Sun, Qiuluan Chen, Ruitian Hou, Zimu Li, Yanjun Zhang, Jin-Cun Zhao, Hao Sun, Bo Feng, Qian Wang, Haisu Yi, Peiyu Hu, Pingchao Li, Yudi Zhang, Zhilong Chen, Xuefeng Niu, Xiaolin Zhong, Liang Jin, Xiaofeng Liu, Kun Qu, Katarzyna A Ciazynska, Andrew P Carter, John A G Briggs, Jizheng Chen, Jin-Song Liu, Xinwen Chen, Jun He, Ling Chen, Xiaoli Xiong
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nature microbiology 7 (10) (2022)
Miao-Miao Zhao, Yun Zhu, Li Zhang, Gongxun Zhong, Linhua Tai, Shuo Liu, Guoliang Yin, Jing Lu, Qiong He, Ming-Jia Li, Ru-Xuan Zhao, Hao Wang, Wei Jin Huang, Changfa Fan, Lei Shuai, Zhiyuan Wen, Chong Wang, Xijun He, Qiuluan Chen, Banghui Liu, Xiaoli Xiong, Zhi-Gao Bu, You-Chun Wang, Fei Sun, Jin-Kui Yang
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies. Cell discovery 8 (1) (2022)
Kun Qu, Qiuluan Chen, Katarzyna A Ciazynska, Banghui Liu, Xixi Zhang, Jingjing Wang, Yujie He, Jiali Guan, Jun He, Tian Liu, Xiaofei Zhang, Andrew P Carter, Xiaoli Xiong, John A G Briggs
Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike. PLoS pathogens 18 (7) (2022)
Maximilian M Sauer, M Alejandra Tortorici, Young-Jun Park, Alexandra C Walls, Leah Homad, Oliver J Acton, John E Bowen, Chunyan Wang, Xiaoli Xiong, Willem de van der Schueren, Joel Quispe, Benjamin G Hoffstrom, Berend-Jan Bosch, Andrew T McGuire, David J Veesler
Structural basis for broad coronavirus neutralization. Nature structural & molecular biology 28 (6) (2021)
Zunlong Ke, Joaquin Otón, Kun Qu, Mirko Cortese, Vojtech Zila, Lesley McKeane, Takanori Nakane, Jasenko Zivanov, Christopher John Neufeldt, Berati Cerikan, John M Lu, Julia Peukes, Xiaoli Xiong, Hans-Georg Kräusslich, Sjors H W Scheres, Ralf F W Bartenschlager, John A G Briggs
Structures and distributions of SARS-CoV-2 spike proteins on intact virions. Nature 588 (7838) (2020)
Julia T Peukes, Xiaoli Xiong, Simon Erlendsson, Kun Qu, William Wan, Leslie J Calder, Oliver Schraidt, Susann Kummer, Stefan M V Freund, Hans-Georg Kräusslich, John A G Briggs
The native structure of the assembled matrix protein 1 of influenza A virus. Nature 587 (7834) (2020)
Xiaoli Xiong, Kun Qu, Katarzyna A Ciazynska, Myra Hosmillo, Andrew P Carter, Soraya Ebrahimi, Zunlong Ke, Sjors H W Scheres, Laura Bergamaschi, Guinevere L Grice, Ying Zhang, null null, James A Nathan, Stephen Baker, Leo C James, Helen E Baxendale, Ian Goodfellow, Rainer Doffinger, John A G Briggs
A thermostable, closed SARS-CoV-2 spike protein trimer. Nature structural & molecular biology 27 (10) (2020)

Xiaoli Xiong

Publication Activity (10 Years)

Top Topics

Top Venues