Yan Zhang

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 35

Top Topics

Molecular Docking

Pain Management

Acinetobacter Baumannii

Structure Activity Relationship

Top Venues

Journal of medicinal chemistry

ACS chemical neuroscience

Molecules (Basel, Switzerland)

RSC medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Celsey M St Onge, Piyusha P Pagare, Yi Zheng, Michelle Arriaga, David L Stevens, Rolando E Mendez, Justin L Poklis, Matthew S Halquist, Dana E Selley, William L Dewey, Matthew L Banks, Yan Zhang
Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. Journal of medicinal chemistry (2024)
Celsey M St Onge, Piyusha P Pagare, Yi Zheng, Michelle Arriaga, David L Stevens, Rolando E Mendez, Justin L Poklis, Matthew S Halquist, Dana E Selley, William L Dewey, Matthew L Banks, Yan Zhang
Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. Journal of medicinal chemistry 67 (11) (2024)
Celsey M St Onge, Piyusha P Pagare, Yi Zheng, Michelle Arriaga, David L Stevens, Rolando E Mendez, Justin L Poklis, Matthew S Halquist, Dana E Selley, William L Dewey, Matthew L Banks, Yan Zhang
Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. Journal of medicinal chemistry 67 (11) (2024)
Shadid U Zaman, Piyusha P Pagare, Hongguang Ma, Rosalie G Hoyle, Yan Zhang, Jiong Li
Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling. RSC medicinal chemistry (2024)
Celsey M St Onge, Piyusha P Pagare, Yi Zheng, Michelle Arriaga, David L Stevens, Rolando E Mendez, Justin L Poklis, Matthew S Halquist, Dana E Selley, William L Dewey, Matthew L Banks, Yan Zhang
Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. Journal of medicinal chemistry 67 (11) (2024)
S Stevens Negus, Celsey M St Onge, Young K Lee, Mengchu Li, Kenner C Rice, Yan Zhang
Effects of Selective and Mixed-Action Kappa and Delta Opioid Receptor Agonists on Pain-Related Behavioral Depression in Mice. Molecules (Basel, Switzerland) 29 (14) (2024)
S Stevens Negus, Celsey M St Onge, Young K Lee, Mengchu Li, Kenner C Rice, Yan Zhang
Effects of Selective and Mixed-Action Kappa and Delta Opioid Receptor Agonists on Pain-Related Behavioral Depression in Mice. Molecules (Basel, Switzerland) 29 (14) (2024)
S Stevens Negus, Celsey M St Onge, Young K Lee, Mengchu Li, Kenner C Rice, Yan Zhang
Effects of Selective and Mixed-Action Kappa and Delta Opioid Receptor Agonists on Pain-Related Behavioral Depression in Mice. Molecules (Basel, Switzerland) 29 (14) (2024)
Celsey M St Onge, Piyusha P Pagare, Yi Zheng, Michelle Arriaga, David L Stevens, Rolando E Mendez, Justin L Poklis, Matthew S Halquist, Dana E Selley, William L Dewey, Matthew L Banks, Yan Zhang
Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments. Journal of medicinal chemistry 67 (11) (2024)
Mengchu Li, Piyusha P Pagare, Hongguang Ma, Celsey M St Onge, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression. Journal of medicinal chemistry 67 (1) (2023)
Mengchu Li, Piyusha P Pagare, Hongguang Ma, Celsey M St Onge, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression. Journal of medicinal chemistry (2023)
Mengchu Li, Piyusha P Pagare, Hongguang Ma, Celsey M St Onge, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression. Journal of medicinal chemistry 67 (1) (2023)
Mengchu Li, Piyusha P Pagare, Hongguang Ma, Celsey M St Onge, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression. Journal of medicinal chemistry 67 (1) (2023)
Hongguang Ma, Piyusha P Pagare, Mengchu Li, Logan T Neel, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Structural Alterations of the "Address" Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity. Journal of medicinal chemistry (2022)
Piyusha P Pagare, Mengchu Li, Yi Zheng, Abhishek S Kulkarni, Samuel Obeng, Boshi Huang, Christian Ruiz, James C Gillespie, Rolando E Mendez, David L Stevens, Justin L Poklis, Matthew S Halquist, William L Dewey, Dana E Selley, Yan Zhang
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists. Journal of medicinal chemistry 65 (6) (2022)
Piyusha P Pagare, Samuel Obeng, Boshi Huang, Madison M Marcus, Katherine L Nicholson, Andrew E Townsend, Matthew L Banks, Yan Zhang
Preclinical Characterization and Development on NAQ as a Mu Opioid Receptor Partial Agonist for Opioid Use Disorder Treatment. ACS pharmacology & translational science 5 (11) (2022)
Boshi Huang, Mengchu Li, Pornprom Klongkumnuankarn, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment. Journal of medicinal chemistry 65 (6) (2022)
Mengchu Li, David L Stevens, Michelle Arriaga, E Andrew Townsend, Rolando E Mendez, Nadejda A Blajkevch, Dana E Selley, Matthew L Banks, S Stevens Negus, William L Dewey, Yan Zhang
Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure-Activity Relationship Study on Nalfurafine Analogues. ACS chemical neuroscience (2022)
Hongguang Ma, Piyusha P Pagare, Mengchu Li, Logan T Neel, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Structural Alterations of the "Address" Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity. Journal of medicinal chemistry 66 (1) (2022)
Hongguang Ma, Piyusha P Pagare, Mengchu Li, Logan T Neel, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Structural Alterations of the "Address" Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity. Journal of medicinal chemistry 66 (1) (2022)
Hongguang Ma, Piyusha P Pagare, Mengchu Li, Logan T Neel, Rolando E Mendez, James C Gillespie, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Structural Alterations of the "Address" Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity. Journal of medicinal chemistry 66 (1) (2022)
Boshi Huang, Huiqun Wang, Yi Zheng, Mengchu Li, Guifeng Kang, Victor Barreto-de-Souza, Nima Nassehi, Pamela E Knapp, Dana E Selley, Kurt F Hauser, Yan Zhang
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity. Journal of medicinal chemistry 64 (11) (2021)
Huiqun Wang, Danni Cao, James C Gillespie, Rolando E Mendez, Dana E Selley, Lee-Yuan Liu-Chen, Yan Zhang
Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators. Future medicinal chemistry 13 (6) (2021)
Huiqun Wang, Bethany A Reinecke, Yan Zhang
Computational insights into the molecular mechanisms of differentiated allosteric modulation at the mu opioid receptor by structurally similar bitopic modulators. Journal of computer-aided molecular design 34 (8) (2020)
Danni Cao, Peng Huang, Yi-Ting Chiu, Chongguang Chen, Huiqun Wang, Mengchu Li, Yi Zheng, Frederick J Ehlert, Yan Zhang, Lee-Yuan Liu-Chen
Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects. ACS chemical neuroscience 11 (19) (2020)
Piyusha P Pagare, Mohini S Ghatge, Qiukan Chen, Faik N Musayev, Jurgen Venitz, Osheiza Abdulmalik, Yan Zhang, Martin K Safo
Exploration of Structure-Activity Relationship of Aromatic Aldehydes Bearing Pyridinylmethoxy-Methyl Esters as Novel Antisickling Agents. Journal of medicinal chemistry 63 (23) (2020)
Bethany A Reinecke, Guifeng Kang, Yi Zheng, Samuel Obeng, Huijun Zhang, Dana E Selley, Jing An, Yan Zhang
Design and synthesis of a bivalent probe targeting the putative mu opioid receptor and chemokine receptor CXCR4 heterodimer. RSC medicinal chemistry 11 (1) (2019)
Yi Zheng, Samuel Obeng, Huiqun Wang, Abdulmajeed M Jali, Bharath Peddibhotla, Dwight A Williams, Chuanchun Zou, David L Stevens, William L Dewey, Hamid I Akbarali, Dana E Selley, Yan Zhang
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands. Journal of medicinal chemistry 62 (2) (2019)
Yongle Du, Ana Lisa Valenciano, Yumin Dai, Yi Zheng, Feng Zhang, Yan Zhang, Jason Clement, Michael Goetz, David G I Kingston, Maria Belen Cassera
Anibamine and Its Analogues: Potent Antiplasmodial Agents from Aniba citrifolia. Journal of natural products 83 (3) (2019)
Hongguang Ma, Samuel Obeng, Huiqun Wang, Yi Zheng, Mengchu Li, Abdulmajeed M Jali, David L Stevens, William L Dewey, Dana E Selley, Yan Zhang
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators. Journal of medicinal chemistry 62 (24) (2019)
Samuel Obeng, Abdulmajeed Jali, Yi Zheng, Huiqun Wang, Kathryn L Schwienteck, Chongguang Chen, David L Stevens, Hamid I Akbarali, William L Dewey, Mathew L Banks, Lee-Yuan Liu-Chen, Dana E Selley, Yan Zhang
Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment. ACS chemical neuroscience 10 (5) (2019)
Bethany A Falls, Yan Zhang
Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach. ACS chemical neuroscience 10 (3) (2018)
Yi Zheng, Samuel Obeng, Huiqun Wang, David L Stevens, Essie Komla, Dana E Selley, William L Dewey, Hamid I Akbarali, Yan Zhang
Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators. ACS chemical neuroscience 9 (12) (2018)
Samuel Obeng, Huiqun Wang, Abdulmajeed Jali, David L Stevens, Hamid I Akbarali, William L Dewey, Dana E Selley, Yan Zhang
Structure-Activity Relationship Studies of 6α- and 6β-Indolylacetamidonaltrexamine Derivatives as Bitopic Mu Opioid Receptor Modulators and Elaboration of the "Message-Address Concept" To Comprehend Their Functional Conversion. ACS chemical neuroscience 10 (3) (2018)
Guoyan G Xu, Piyusha P Pagare, Mohini S Ghatge, Ronni P Safo, Aheema Gazi, Qiukan Chen, Tanya David, Alhumaidi B Alabbas, Faik N Musayev, Jürgen Venitz, Yan Zhang, Martin K Safo, Osheiza Abdulmalik
Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease. Molecular pharmaceutics 14 (10) (2017)