Yang Zhou

Publication Activity (10 Years)

Years Active: 2022-2024
Publications (10 Years): 35

Top Topics

Tyrosine Kinase

Structural Basis

Top Venues

Journal of medicinal chemistry

Journal of chemical information and modeling

Communications chemistry

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Hualin Zhang, Yutong Tu, Zhaofan Tao, Lixin Gao, Shengjie Huang, Mingshan Gao, Jialuo Mao, Yang Zhou, Yupeng Li, Jia Li, Yubo Zhou, Tianfeng Xu
Design, Synthesis, and Biological Evaluation of 2,4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors. ACS medicinal chemistry letters 15 (8) (2024)
Yaoliang Sun, Manman Chen, Yuyan Han, Weiqiang Li, Xiaoyu Ma, Zihan Shi, Yang Zhou, Lan Xu, Lei Yu, Yuxiang Wang, Jinghua Yu, Xingxing Diao, Linghua Meng, Shilin Xu
Discovery of Pyrido[2,3- d ]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment. Journal of medicinal chemistry (2024)
Xuan Zheng, Zhiwen Chen, Ming Guo, Hong Liang, Xiaojuan Song, Yiling Liu, Zhenling Liao, Yan Zhang, Jing Guo, Yang Zhou, Zhi-Min Zhang, Zhengchao Tu, Ye Zhang, Yongheng Chen, Zhang Zhang, Xiaoyun Lu
Structure-Based Optimization of Pyrazinamide-Containing Macrocyclic Derivatives as Fms-like Tyrosine Kinase 3 (FLT3) Inhibitors to Overcome Clinical Mutations. ACS pharmacology & translational science 7 (5) (2024)
Fang Yang, Qianmeng Lin, Xiaojuan Song, Huisi Huang, Xiaojuan Chen, Jianwen Tan, Yun Li, Yang Zhou, Zhengchao Tu, Hongli Du, Zhi-Min Zhang, Raquel Ortega, Xiaojing Lin, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. Journal of medicinal chemistry 67 (4) (2024)
Yiling Liu, Jundong Tan, Shiliang Hu, Muzammal Hussain, Chang Qiao, Yaoquan Tu, Xiaoyun Lu, Yang Zhou
Dynamics Playing a Key Role in the Covalent Binding of Inhibitors to Focal Adhesion Kinase. Journal of chemical information and modeling 64 (15) (2024)
Yaoliang Sun, Manman Chen, Yuyan Han, Weiqiang Li, Xiaoyu Ma, Zihan Shi, Yang Zhou, Lan Xu, Lei Yu, Yuxiang Wang, Jinghua Yu, Xingxing Diao, Linghua Meng, Shilin Xu
Discovery of Pyrido[2,3- d ]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment. Journal of medicinal chemistry 67 (5) (2024)
Xuan Zheng, Zhiwen Chen, Ming Guo, Hong Liang, Xiaojuan Song, Yiling Liu, Zhenling Liao, Yan Zhang, Jing Guo, Yang Zhou, Zhi-Min Zhang, Zhengchao Tu, Ye Zhang, Yongheng Chen, Zhang Zhang, Xiaoyun Lu
Structure-Based Optimization of Pyrazinamide-Containing Macrocyclic Derivatives as Fms-like Tyrosine Kinase 3 (FLT3) Inhibitors to Overcome Clinical Mutations. ACS pharmacology & translational science 7 (5) (2024)
Yiling Liu, Jundong Tan, Shiliang Hu, Muzammal Hussain, Chang Qiao, Yaoquan Tu, Xiaoyun Lu, Yang Zhou
Dynamics Playing a Key Role in the Covalent Binding of Inhibitors to Focal Adhesion Kinase. Journal of chemical information and modeling (2024)
Lu Liu, Fenghua Chen, Shan Li, Tong Yang, ShuZhen Chen, Yang Zhou, Zejian Lin, Guandi Zeng, Pengju Feng, Hong-Bing Shu, Qian Zhou, Ke Ding, Liang Chen
Human/mouse CD137 agonist, JNU-0921, effectively shrinks tumors through enhancing the cytotoxicity of CD8 + T cells in cis and in trans. Science advances 10 (34) (2024)
Lu Liu, Fenghua Chen, Shan Li, Tong Yang, ShuZhen Chen, Yang Zhou, Zejian Lin, Guandi Zeng, Pengju Feng, Hong-Bing Shu, Qian Zhou, Ke Ding, Liang Chen
Human/mouse CD137 agonist, JNU-0921, effectively shrinks tumors through enhancing the cytotoxicity of CD8 + T cells in cis and in trans. Science advances 10 (34) (2024)
Yaoliang Sun, Manman Chen, Yuyan Han, Weiqiang Li, Xiaoyu Ma, Zihan Shi, Yang Zhou, Lan Xu, Lei Yu, Yuxiang Wang, Jinghua Yu, Xingxing Diao, Linghua Meng, Shilin Xu
Discovery of Pyrido[2,3- d ]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment. Journal of medicinal chemistry 67 (5) (2024)
Lu Liu, Fenghua Chen, Shan Li, Tong Yang, ShuZhen Chen, Yang Zhou, Zejian Lin, Guandi Zeng, Pengju Feng, Hong-Bing Shu, Qian Zhou, Ke Ding, Liang Chen
Human/mouse CD137 agonist, JNU-0921, effectively shrinks tumors through enhancing the cytotoxicity of CD8 + T cells in cis and in trans. Science advances 10 (34) (2024)
Hualin Zhang, Yutong Tu, Zhaofan Tao, Lixin Gao, Shengjie Huang, Mingshan Gao, Jialuo Mao, Yang Zhou, Yupeng Li, Jia Li, Yubo Zhou, Tianfeng Xu
Design, Synthesis, and Biological Evaluation of 2,4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors. ACS medicinal chemistry letters 15 (8) (2024)
Fang Yang, Qianmeng Lin, Xiaojuan Song, Huisi Huang, Xiaojuan Chen, Jianwen Tan, Yun Li, Yang Zhou, Zhengchao Tu, Hongli Du, Zhi-Min Zhang, Raquel Ortega, Xiaojing Lin, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. Journal of medicinal chemistry 67 (4) (2024)
Yang Zhou, Jibo Kang, Xiaoyun Lu
Targeting Solvent-Front Mutations for Kinase Drug Discovery: From Structural Basis to Design Strategies. Journal of medicinal chemistry (2024)
Fang Yang, Qianmeng Lin, Xiaojuan Song, Huisi Huang, Xiaojuan Chen, Jianwen Tan, Yun Li, Yang Zhou, Zhengchao Tu, Hongli Du, Zhi-Min Zhang, Raquel Ortega, Xiaojing Lin, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. Journal of medicinal chemistry (2024)
Yebao Chen, Yongjin Wang, Yang Xu, Jiaojiao Sun, Liu Yang, Chenhao Feng, Jia Wang, Yang Zhou, Zhi-Min Zhang, Yonghua Wang
Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase. Communications chemistry 6 (1) (2023)
Yebao Chen, Yongjin Wang, Yang Xu, Jiaojiao Sun, Liu Yang, Chenhao Feng, Jia Wang, Yang Zhou, Zhi-Min Zhang, Yonghua Wang
Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase. Communications chemistry 6 (1) (2023)
Zuqin Wang, Jie Wang, Yongjin Wang, Shuang Xiang, Hengliang Zhou, Shukai Song, Xiaojuan Song, Zhengchao Tu, Yang Zhou, Ke Ding, Zhi-Min Zhang, Zhang Zhang, Xiaoyun Lu
Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. Journal of medicinal chemistry (2023)
Yang Zhou, Junhao Li, Glib V Baryshnikov, Yaoquan Tu
Correction to "Unraveling the Abnormal Molecular Mechanism of Suicide Inhibition of Cytochrome P450 3A4". Journal of chemical information and modeling (2023)
Chungen Li, Yuanyuan Qiao, Xia Jiang, Lianchao Liu, Yang Zheng, Yudi Qiu, Caleb Cheng, Fengtao Zhou, Yang Zhou, Weixue Huang, Xiaomei Ren, Yuzhuo Wang, Zhen Wang, Arul M Chinnaiyan, Ke Ding
Discovery of a First-in-Class Degrader for the Lipid Kinase PIKfyve. Journal of medicinal chemistry (2023)
Yebao Chen, Yongjin Wang, Yang Xu, Jiaojiao Sun, Liu Yang, Chenhao Feng, Jia Wang, Yang Zhou, Zhi-Min Zhang, Yonghua Wang
Molecular insights into the catalytic mechanism of plasticizer degradation by a monoalkyl phthalate hydrolase. Communications chemistry 6 (1) (2023)
Yang Zhou, Hang Yu, Anna Constance Vind, Lulu Kong, Yiling Liu, Xiaojuan Song, Zhengchao Tu, Cai-Hong Yun, Jeff B Smaill, Qing-Wen Zhang, Ke Ding, Simon Bekker-Jensen, Xiaoyun Lu
Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov). Journal of medicinal chemistry (2023)
Qian Li, Tao Zhang, Peiran Song, Linjiang Tong, Fang Feng, Jing Guo, Yang Zhou, Hua Xie, Xiaoyun Lu
Design, Synthesis, and Evaluation of ( R )-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3- d ]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor. Journal of medicinal chemistry (2023)
Zuqin Wang, Jie Wang, Yongjin Wang, Shuang Xiang, Xiaojuan Song, Zhengchao Tu, Yang Zhou, Zhi-Min Zhang, Zhang Zhang, Ke Ding, Xiaoyun Lu
Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. Journal of medicinal chemistry 65 (8) (2022)
Shan Li, Hongfei Si, Xiaojuan Song, Chong Lei, Xiaoqiang He, Jie Wang, Yiling Liu, Yang Zhou, Jian-Guo Song, Lijie Peng, Xia Tang, Shingpan Chan, Xiaomei Ren, Zhengchao Tu, Zhengqiu Li, Zhen Wang, Zhang Zhang, Ke Ding
Discovery of Hexahydrofuro[3,2- b ]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant. Journal of medicinal chemistry 65 (15) (2022)
Chaofan Wang, Jie Li, Lingzhi Qu, Xia Tang, Xiaojuan Song, Fang Yang, Xiaojuan Chen, Qianmeng Lin, Weibin Lin, Yang Zhou, ZhengChao Tu, Yongheng Chen, Zhang Zhang, Xiaoyun Lu
Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. Journal of medicinal chemistry 65 (22) (2022)
Hao Chen, Mengzhen Lai, Tao Zhang, Yuqing Chen, Linjiang Tong, Sujie Zhu, Yang Zhou, Xiaomei Ren, Jian Ding, Hua Xie, Xiaoyun Lu, Ke Ding
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. Journal of medicinal chemistry 65 (9) (2022)
Yang Zhou, Junhao Li, Glib V Baryshnikov, Yaoquan Tu
Unraveling the Abnormal Molecular Mechanism of Suicide Inhibition of Cytochrome P450 3A4. Journal of chemical information and modeling (2022)
Zhen Zhang, Jie Li, Hao Chen, Jing Huang, Xiaojuan Song, Zheng-Chao Tu, Zhang Zhang, Lijie Peng, Yang Zhou, Ke Ding
Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors. Journal of medicinal chemistry 65 (4) (2022)
Shingpan Chan, Yunong Zhang, Jie Wang, Qiuchun Yu, Xia Peng, Jian Zou, Licheng Zhou, Li Tan, Yunxin Duan, Yang Zhou, Hoon Hur, Jing Ai, Zhen Wang, Xiaomei Ren, Zhang Zhang, Ke Ding
Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors. Journal of medicinal chemistry 65 (22) (2022)
Dan Teng, Yang Zhou, Yun Tang, Guixia Liu, Yaoquan Tu
Mechanistic Studies on the Stereoselectivity of FFAR1 Modulators. Journal of chemical information and modeling 62 (15) (2022)
Min Shao, Xiaojuan Chen, Fang Yang, Xiaojuan Song, Yang Zhou, Qianmeng Lin, Ying Fu, Raquel Ortega, Xiaojing Lin, Zhengchao Tu, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. Journal of medicinal chemistry 65 (6) (2022)
Jianzhang Yang, Yu Chang, Jean Ching-Yi Tien, Zhen Wang, Yang Zhou, Pujuan Zhang, Weixue Huang, Josh Vo, Ingrid J Apel, Cynthia Wang, Victoria Zhixuan Zeng, Yunhui Cheng, Shuqin Li, George Xiaoju Wang, Arul M Chinnaiyan, Ke Ding
Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13. Journal of medicinal chemistry 65 (16) (2022)
Yang Zhou, Shuang Xiang, Fang Yang, Xiaoyun Lu
Targeting Gatekeeper Mutations for Kinase Drug Discovery. Journal of medicinal chemistry 65 (23) (2022)