Xiaoyun Lu

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Topics

Acute Lymphoblastic Leukemia

Tyrosine Kinase

Structural Basis

Top Venues

Journal of medicinal chemistry

ACS pharmacology & translational science

Journal of chemical information and modeling

Journal of the American Chemical Society

This page only lists publications with an associated author ORCID identifier.

Publications

Chaofan Wang, Yan Fang, Ziqin Zhou, Zhuoheng Liu, Fang Feng, Xuan Wan, Yan Li, Shuang Liu, Jian Ding, Zhi-Min Zhang, Hua Xie, Xiaoyun Lu
Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer. Journal of medicinal chemistry (2024)
Xuan Zheng, Zhiwen Chen, Ming Guo, Hong Liang, Xiaojuan Song, Yiling Liu, Zhenling Liao, Yan Zhang, Jing Guo, Yang Zhou, Zhi-Min Zhang, Zhengchao Tu, Ye Zhang, Yongheng Chen, Zhang Zhang, Xiaoyun Lu
Structure-Based Optimization of Pyrazinamide-Containing Macrocyclic Derivatives as Fms-like Tyrosine Kinase 3 (FLT3) Inhibitors to Overcome Clinical Mutations. ACS pharmacology & translational science 7 (5) (2024)
Fang Yang, Qianmeng Lin, Xiaojuan Song, Huisi Huang, Xiaojuan Chen, Jianwen Tan, Yun Li, Yang Zhou, Zhengchao Tu, Hongli Du, Zhi-Min Zhang, Raquel Ortega, Xiaojing Lin, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. Journal of medicinal chemistry 67 (4) (2024)
Hong Wang, Huizi Sun, Jie Huang, Zhenhua Zhang, Guodi Cai, Chaofan Wang, Kai Xiao, Xiao-Feng Xiong, Jian Zhang, Peiqing Liu, Xiaoyun Lu, Weineng Feng, Jun-Jian Wang
Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer. EMBO molecular medicine (2024)
Yiling Liu, Jundong Tan, Shiliang Hu, Muzammal Hussain, Chang Qiao, Yaoquan Tu, Xiaoyun Lu, Yang Zhou
Dynamics Playing a Key Role in the Covalent Binding of Inhibitors to Focal Adhesion Kinase. Journal of chemical information and modeling 64 (15) (2024)
Guanghui Tang, Xuan Wang, Huisi Huang, Manyi Xu, Xingyu Ma, Fengfei Miao, Xiaoyun Lu, Chong-Jing Zhang, Liqian Gao, Zhi-Min Zhang, Shao Q Yao
Small Molecule-Induced Post-Translational Acetylation of Catalytic Lysine of Kinases in Mammalian Cells. Journal of the American Chemical Society (2024)
Xuan Zheng, Zhiwen Chen, Ming Guo, Hong Liang, Xiaojuan Song, Yiling Liu, Zhenling Liao, Yan Zhang, Jing Guo, Yang Zhou, Zhi-Min Zhang, Zhengchao Tu, Ye Zhang, Yongheng Chen, Zhang Zhang, Xiaoyun Lu
Structure-Based Optimization of Pyrazinamide-Containing Macrocyclic Derivatives as Fms-like Tyrosine Kinase 3 (FLT3) Inhibitors to Overcome Clinical Mutations. ACS pharmacology & translational science 7 (5) (2024)
Yiling Liu, Jundong Tan, Shiliang Hu, Muzammal Hussain, Chang Qiao, Yaoquan Tu, Xiaoyun Lu, Yang Zhou
Dynamics Playing a Key Role in the Covalent Binding of Inhibitors to Focal Adhesion Kinase. Journal of chemical information and modeling (2024)
Fang Yang, Qianmeng Lin, Xiaojuan Song, Huisi Huang, Xiaojuan Chen, Jianwen Tan, Yun Li, Yang Zhou, Zhengchao Tu, Hongli Du, Zhi-Min Zhang, Raquel Ortega, Xiaojing Lin, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. Journal of medicinal chemistry 67 (4) (2024)
Yang Zhou, Jibo Kang, Xiaoyun Lu
Targeting Solvent-Front Mutations for Kinase Drug Discovery: From Structural Basis to Design Strategies. Journal of medicinal chemistry (2024)
Guanghui Tang, Xuan Wang, Huisi Huang, Manyi Xu, Xingyu Ma, Fengfei Miao, Xiaoyun Lu, Chong-Jing Zhang, Liqian Gao, Zhi-Min Zhang, Shao Q Yao
Small Molecule-Induced Post-Translational Acetylation of Catalytic Lysine of Kinases in Mammalian Cells. Journal of the American Chemical Society 146 (34) (2024)
Fang Yang, Qianmeng Lin, Xiaojuan Song, Huisi Huang, Xiaojuan Chen, Jianwen Tan, Yun Li, Yang Zhou, Zhengchao Tu, Hongli Du, Zhi-Min Zhang, Raquel Ortega, Xiaojing Lin, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. Journal of medicinal chemistry (2024)
Zuqin Wang, Jie Wang, Yongjin Wang, Shuang Xiang, Hengliang Zhou, Shukai Song, Xiaojuan Song, Zhengchao Tu, Yang Zhou, Ke Ding, Zhi-Min Zhang, Zhang Zhang, Xiaoyun Lu
Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations. Journal of medicinal chemistry (2023)
Hao Chen, Shiliang Hu, Adam V Patterson, Jeff B Smaill, Ke Ding, Xiaoyun Lu
Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations. Journal of medicinal chemistry (2023)
Chaofan Wang, Xiaoyun Lu
Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy. Journal of medicinal chemistry (2023)
Yang Zhou, Hang Yu, Anna Constance Vind, Lulu Kong, Yiling Liu, Xiaojuan Song, Zhengchao Tu, Cai-Hong Yun, Jeff B Smaill, Qing-Wen Zhang, Ke Ding, Simon Bekker-Jensen, Xiaoyun Lu
Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov). Journal of medicinal chemistry (2023)
Qian Li, Tao Zhang, Peiran Song, Linjiang Tong, Fang Feng, Jing Guo, Yang Zhou, Hua Xie, Xiaoyun Lu
Design, Synthesis, and Evaluation of ( R )-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3- d ]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor. Journal of medicinal chemistry (2023)
Zuqin Wang, Jie Wang, Yongjin Wang, Shuang Xiang, Xiaojuan Song, Zhengchao Tu, Yang Zhou, Zhi-Min Zhang, Zhang Zhang, Ke Ding, Xiaoyun Lu
Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. Journal of medicinal chemistry 65 (8) (2022)
Chaofan Wang, Jie Li, Lingzhi Qu, Xia Tang, Xiaojuan Song, Fang Yang, Xiaojuan Chen, Qianmeng Lin, Weibin Lin, Yang Zhou, ZhengChao Tu, Yongheng Chen, Zhang Zhang, Xiaoyun Lu
Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. Journal of medicinal chemistry 65 (22) (2022)
Hao Chen, Mengzhen Lai, Tao Zhang, Yuqing Chen, Linjiang Tong, Sujie Zhu, Yang Zhou, Xiaomei Ren, Jian Ding, Hua Xie, Xiaoyun Lu, Ke Ding
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. Journal of medicinal chemistry 65 (9) (2022)
Shan Li, Tao Zhang, Su-Jie Zhu, Chong Lei, Mengzhen Lai, Lijie Peng, Linjiang Tong, Zilu Pang, Xiaoyun Lu, Jian Ding, Xiaomei Ren, Cai-Hong Yun, Hua Xie, Ke Ding
Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR T790M/C797S Mutants. ACS medicinal chemistry letters 13 (2) (2022)
Fang Yang, Xiaojuan Chen, Xiaojuan Song, Raquel Ortega, Xiaojing Lin, Wuqing Deng, Jing Guo, Zhengchao Tu, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. Journal of medicinal chemistry 65 (21) (2022)
Jibu Lu, Yongjun Huang, Jing Huang, Rui He, Minhao Huang, Xiaoyun Lu, Yong Xu, Fengtao Zhou, Zhang Zhang, Ke Ding
Discovery of the First Examples of Threonine Tyrosine Kinase PROTAC Degraders. Journal of medicinal chemistry 65 (3) (2022)
Min Shao, Xiaojuan Chen, Fang Yang, Xiaojuan Song, Yang Zhou, Qianmeng Lin, Ying Fu, Raquel Ortega, Xiaojing Lin, Zhengchao Tu, Adam V Patterson, Jeff B Smaill, Yongheng Chen, Xiaoyun Lu
Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. Journal of medicinal chemistry 65 (6) (2022)
Yang Zhou, Shuang Xiang, Fang Yang, Xiaoyun Lu
Targeting Gatekeeper Mutations for Kinase Drug Discovery. Journal of medicinal chemistry 65 (23) (2022)
Zuqin Wang, Ting Ran, Fang Xu, Chang Wen, Shukai Song, Yang Zhou, Hongming Chen, Xiaoyun Lu
Deep learning-driven scaffold hopping in the discovery of Akt kinase inhibitors. Chemical communications (Cambridge, England) 57 (81) (2021)
Xiaoyun Lu, Jeff B Smaill, Adam V Patterson, Ke Ding
Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors. Journal of medicinal chemistry 65 (1) (2021)
Xiaoyun Lu, Jeff B Smaill, Ke Ding
New Promise and Opportunities for Allosteric Kinase Inhibitors. Angewandte Chemie (International ed. in English) 59 (33) (2020)
Hao Chen, Jeff B Smaill, Tongzheng Liu, Ke Ding, Xiaoyun Lu
Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics. Journal of medicinal chemistry 63 (23) (2020)
Liang Jiang, Xiaolu Wang, Yuting Wang, Fang Xu, Zhang Zhang, Ke Ding, Xiaoyun Lu
The synthesis and biological evaluation of sanguinarine derivatives as anti-non-small cell lung cancer agents. RSC medicinal chemistry 11 (2) (2020)
Xiaoyun Lu, Jeff B Smaill, Ke Ding
Medicinal Chemistry Strategies for the Development of Kinase Inhibitors Targeting Point Mutations. Journal of medicinal chemistry 63 (19) (2020)
Jiayi Shen, Tao Zhang, Su-Jie Zhu, Min Sun, Linjiang Tong, Mengzhen Lai, Rong Zhang, Wei Xu, Ruibo Wu, Jian Ding, Cai-Hong Yun, Hua Xie, Xiaoyun Lu, Ke Ding
Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S). Journal of medicinal chemistry 62 (15) (2019)
Dongsheng Zhu, Huocong Huang, Daniel M Pinkas, Jinfeng Luo, Debolina Ganguly, Alice E Fox, Emily Arner, Qiuping Xiang, Zheng-Chao Tu, Alex N Bullock, Rolf A Brekken, Ke Ding, Xiaoyun Lu
2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. Journal of medicinal chemistry 62 (16) (2019)
Jianzhang Yang, Marthandam Asokan Shibu, Lulu Kong, Jinfeng Luo, Farheen BadrealamKhan, Yanhui Huang, Zheng-Chao Tu, Cai-Hong Yun, Chih-Yang Huang, Ke Ding, Xiaoyun Lu
Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors. Journal of medicinal chemistry 63 (5) (2019)
Xiaoyun Lu, Hao Chen, Adam V Patterson, Jeff B Smaill, Ke Ding
Fibroblast Growth Factor Receptor 4 (FGFR4) Selective Inhibitors as Hepatocellular Carcinoma Therapy: Advances and Prospects. Journal of medicinal chemistry 62 (6) (2018)
Zhen Wang, Yali Zhang, Daniel M Pinkas, Alice E Fox, Jinfeng Luo, Huocong Huang, Shengyang Cui, Qiuping Xiang, Tingting Xu, Qiuju Xun, Dongsheng Zhu, Zhengchao Tu, Xiaomei Ren, Rolf A Brekken, Alex N Bullock, Guang Liang, Ke Ding, Xiaoyun Lu
Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. Journal of medicinal chemistry 61 (17) (2018)
Xiaoyun Lu, Xianglong Hu, Zhiyong Liu, Tianyu Zhang, Ruibing Wang, Baojie Wan, Scott G Franzblau, Qidong You
Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant Mycobacterium tuberculosis. MedChemComm 8 (6) (2017)