Yongxin Han

Publication Activity (10 Years)

Years Active: 2021-2024
Publications (10 Years): 13

Top Topics

Metastatic Colorectal Cancer

Functional Connectivity

Top Venues

Cancer discovery

Journal of medicinal chemistry

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Xiaoshen Ma, David L Sloman, Ruchia Duggal, Kenneth D Anderson, Jeanine E Ballard, Indu Bharathan, Christopher Brynczka, Symon Gathiaka, Timothy J Henderson, Thomas W Lyons, Richard Miller, Erik V Munsell, Peter Orth, Ryan D Otte, Anandan Palani, Danica A Rankic, Michelle R Robinson, Aaron C Sather, Nicolas Solban, Xuelei Sherry Song, Xin Wen, Zangwei Xu, Yi Yang, Ruojing Yang, Phil J Day, Alexander Stoeck, David Jonathan Bennett, Yongxin Han
Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS G12C Inhibitor. Journal of medicinal chemistry 67 (13) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers. Cancer discovery (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Xiaoshen Ma, David L Sloman, Ruchia Duggal, Kenneth D Anderson, Jeanine E Ballard, Indu Bharathan, Christopher Brynczka, Symon Gathiaka, Timothy J Henderson, Thomas W Lyons, Richard Miller, Erik V Munsell, Peter Orth, Ryan D Otte, Anandan Palani, Danica A Rankic, Michelle R Robinson, Aaron C Sather, Nicolas Solban, Xuelei Sherry Song, Xin Wen, Zangwei Xu, Yi Yang, Ruojing Yang, Phil J Day, Alexander Stoeck, David Jonathan Bennett, Yongxin Han
Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS G12C Inhibitor. Journal of medicinal chemistry 67 (13) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers. Cancer discovery (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Xiaoshen Ma, David L Sloman, Ruchia Duggal, Kenneth D Anderson, Jeanine E Ballard, Indu Bharathan, Christopher Brynczka, Symon Gathiaka, Timothy J Henderson, Thomas W Lyons, Richard Miller, Erik V Munsell, Peter Orth, Ryan D Otte, Anandan Palani, Danica A Rankic, Michelle R Robinson, Aaron C Sather, Nicolas Solban, Xuelei Sherry Song, Xin Wen, Zangwei Xu, Yi Yang, Ruojing Yang, Phil J Day, Alexander Stoeck, David Jonathan Bennett, Yongxin Han
Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS G12C Inhibitor. Journal of medicinal chemistry (2024)
Michael T Rudd, Peter J Manley, Barbara Hanney, Zhaoyang Meng, Youheng Shu, Pablo de Leon, Jessica L Frie, Yongxin Han, Jenny Miu-Chun Wai, Zhi-Qiang Yang, James J Perkins, Danielle M Hurzy, Jesse J Manikowski, Hong Zhu, Christopher J Bungard, Antonella Converso, Robert S Meissner, Mali L Cosden, Ikuo Hayashi, Lei Ma, Julie O'Brien, Victor N Uebele, Joel B Schachter, Neetesh Bhandari, Gwendolyn J Ward, Kerry L Fillgrove, Bing Lu, Yuexia Liang, David C Dubost, Vanita Puri, Donnie M Eddins, Joshua D Vardigan, Robert E Drolet, Jonathan T Kern, Jason M Uslaner
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS medicinal chemistry letters 14 (8) (2023)
Derun Li, David L Sloman, Abdelghani Achab, Hua Zhou, Meredeth A McGowan, Catherine White, Craig Gibeau, Hongjun Zhang, Qinglin Pu, Indu Bharathan, Brett Hopkins, Kun Liu, Heidi Ferguson, Andreas Verras, Charles A Lesburg, Theodore A Martinot, Ji Qi, Zhiguo J Song, Jingjun Yin, Huangguang Zhang, Licheng Song, Baoqiang Wan, Suzanne M D'Addio, Nicolas Solban, J Richard Miller, Beata Zamlynny, Alan Bass, Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard, Jude Ferraro, Jin Zhai, Ian Knemeyer, Karin M Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing. Journal of medicinal chemistry 65 (8) (2022)
Brett Hopkins, Hongjun Zhang, Indu Bharathan, Derun Li, Qinglin Pu, Hua Zhou, Theodore A Martinot, Andreas Verras, Alfred Lammens, Charles A Lesburg, Ryan D Cohen, Jeanine Ballard, Ian Knemeyer, Karin Otte, Stella Vincent, J Richard Miller, Nicolas Solban, Mangeng Cheng, Prasanthi Geda, Nadya Smotrov, Xuelei Song, David Jonathan Bennett, Yongxin Han
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors. ACS medicinal chemistry letters 12 (9) (2021)