Arvin C Dar

ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 14

Top Venues

Cancer discovery

Nature cancer

Nature chemical biology

Nature biotechnology

Icahn School of Medicine at Mount Sinai

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Icahn School of Medicine at Mount Sinai

United States

Associate Professor :: Oncological Sciences

Education History

University of Toronto

Canada

PHD

Publications

Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers. Cancer discovery (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers. Cancer discovery (2024)
Meagan B Ryan, Bradley Quade, Natasha Schenk, Zhong Fang, Marshall Zingg, Steven E Cohen, Brooke M Swalm, Chun Li, Aysegul Ozen, Chaoyang Ye, Maria Stella Ritorto, Xin Huang, Arvin C Dar, Yongxin Han, Klaus P Hoeflich, Michael Hale, Margit Hagel
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer discovery 14 (7) (2024)
Alex Rialdi, Mary Duffy, Alex P Scopton, Frank Fonseca, Julia Nanyi Zhao, Megan Schwarz, Pedro Molina-Sanchez, Slim Mzoughi, Elisa Arceci, Jordi Abril-Fornaguera, Austin Meadows, Marina Ruiz de Galarreta, Denis Torre, Kyna Reyes, Yan Ting Lim, Felix Rosemann, Zaigham M Khan, Kevin Mohammed, Xuedi Wang, Xufen Yu, Manikandan Lakshmanan, Ravisankar Rajarethinam, Soo Yong Tan, Jian Jin, Augusto Villanueva, Eleftherios Michailidis, Ype P De Jong, Charles M Rice, Ivan Marazzi, Dan Hasson, Josep M Llovet, Radoslaw Mikolaj Sobota, Amaia Lujambio, Ernesto Guccione, Arvin C Dar
WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. Nature cancer (2023)
William M Marsiglia, Arthur Chow, Zaigham M Khan, Liu He, Arvin C Dar
Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes. Nature chemical biology (2023)
Donita C Brady, Julija Hmeljak, Arvin C Dar
Understanding and drugging RAS: 40 years to break the tip of the iceberg. Disease models & mechanisms 15 (2) (2022)
Liu He, Arvin C Dar
Targeting drug-resistant mutations in ALK. Nature cancer 3 (6) (2022)
Megan Schwarz, Denis Torre, Daniel Lozano-Ojalvo, Anthony T Tan, Tommaso Tabaglio, Slim Mzoughi, Rodrigo Sanchez-Tarjuelo, Nina Le Bert, Joey Ming Er Lim, Sandra Hatem, Kevin Tuballes, Carmen Camara, Eduardo Lopez-Granados, Estela Paz-Artal, Rafael Correa-Rocha, Alberto Ortiz Arduan, Marcos Lopez-Hoyos, Jose M Portolés, Isabel Cervera, Maria Gonzalez-Perez, Irene Bodega-Mayor, Patricia Conde, Jesús Oteo-Iglesias, Alberto M Borobia, Antonio J Carcas, Jesús Frías, Cristóbal Belda-Iniesta, Jessica Sook Yuin Ho, Kemuel Nunez, Saboor Hekmaty, Kevin Mohammed, William M Marsiglia, Juan Manuel Carreño, Arvin C Dar, Cecilia Berin, Giuseppe Nicoletti, Isabella Della Noce, Lorenzo Colombo, Cristina Lapucci, Graziano Santoro, Maurizio Ferrari, Kai Nie, Manishkumar Patel, Vanessa Barcessat, Sacha Gnjatic, Jocelyn Harris, Robert Sebra, Miriam Merad, Florian Krammer, Seunghee Kim-Schulze, Ivan Marazzi, Antonio Bertoletti, Jordi Ochando, Ernesto Guccione
Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR. Nature biotechnology 40 (11) (2022)
Ryan H B Smith, Zaigham M Khan, Peter Man-Un Ung, Alex P Scopton, Lisa Silber, Seshat M Mack, Alexander M Real, Avner Schlessinger, Arvin C Dar
Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα. Biochemistry 60 (4) (2021)
Zaigham M Khan, Alexander M Real, William M Marsiglia, Arthur Chow, Mary E Duffy, Jayasudhan R Yerabolu, Alex P Scopton, Arvin C Dar
Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature 588 (7838) (2020)

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Publication Activity (10 Years)

Top Topics

Top Venues

Arvin C Dar