SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance.

Marta J Llorca-Cardenosa Lauren I Aronson Dragomir B Krastev Jadwiga Nieminuszczy John Alexander Feifei Song Malgorzata Dylewska Ronan Broderick Rachel Brough Astrid Zimmermann Frank T Zenke Bora Gurel Ruth Riisnaes Ana Ferreira Theodoros I Roumeliotis Jyoti Sharma Choudhary Stephen J Pettitt Johann S de Bono Andres Cervantes Syed Haider Wojciech Niedzwiedz Christopher J Lord Irene Y Chong

Published in: Cancer research (2022)

These findings reveal how cancer cells acquire resistance to ATRi and identify pathways that could be targeted to enhance the overall effectiveness of these inhibitors.

Keyphrases

randomized controlled trial
systematic review
cancer therapy
single cell
tyrosine kinase
gene expression
drug delivery
protein kinase