Stephen J Pettitt (Stephen Pettit, Stephen Pettitt)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 26

Top Venues

Oncogene

Nature communications

Cancer discovery

Cancer research

This page only lists publications with an associated author ORCID identifier.

Publications

Jeffrey C Francis, Amy Capper, Alistair G Rust, Klea Ferro, Jian Ning, Wei Yuan, Johann de Bono, Stephen J Pettitt, Amanda Swain
Identification of genes that promote PI3K pathway activation and prostate tumour formation. Oncogene (2024)
Jeffrey C Francis, Amy Capper, Alistair G Rust, Klea Ferro, Jian Ning, Wei Yuan, Johann de Bono, Stephen J Pettitt, Amanda Swain
Identification of genes that promote PI3K pathway activation and prostate tumour formation. Oncogene 43 (24) (2024)
Jeffrey C Francis, Amy Capper, Alistair G Rust, Klea Ferro, Jian Ning, Wei Yuan, Johann de Bono, Stephen J Pettitt, Amanda Swain
Identification of genes that promote PI3K pathway activation and prostate tumour formation. Oncogene 43 (24) (2024)
Jeffrey C Francis, Amy Capper, Alistair G Rust, Klea Ferro, Jian Ning, Wei Yuan, Johann de Bono, Stephen J Pettitt, Amanda Swain
Identification of genes that promote PI3K pathway activation and prostate tumour formation. Oncogene 43 (24) (2024)
Jeffrey C Francis, Amy Capper, Alistair G Rust, Klea Ferro, Jian Ning, Wei Yuan, Johann de Bono, Stephen J Pettitt, Amanda Swain
Identification of genes that promote PI3K pathway activation and prostate tumour formation. Oncogene 43 (24) (2024)
Colm J Ryan, Lovely Paul Solomon Devakumar, Stephen J Pettitt, Christopher J Lord
Complex synthetic lethality in cancer. Nature genetics (2023)
Stephen J Pettitt, Nan Shao, Diana Zatreanu, Jessica Frankum, Ilirjana Bajrami, Rachel Brough, Dragomir B Krastev, Theodoros I Roumeliotis, Jyoti Sharma Choudhary, Sonja Lorenz, Alistair Rust, Johann S de Bono, Timothy Anthony Yap, Andrew N J Tutt, Christopher J Lord
A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant. Oncogene (2023)
Philip Bland, Harry Saville, Patty T Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Guy Pratt, Ceri E Oldreive, Tatjana Stankovic, Samantha Barlow, Helen Kalirai, Sarah E Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen J Pettitt, Jyoti Sharma Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher J Lord, Rachael Natrajan
SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response. Nature genetics (2023)
Joseph S Baxter, Rachel Brough, Dragomir B Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I Roumeliotis, Zuza Kozik, Jyoti S Choudhary, Syed Haider, Stephen J Pettitt, Andrew N J Tutt, Christopher J Lord
Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7. Molecular oncology (2023)
Marta J Llorca-Cardenosa, Lauren I Aronson, Dragomir B Krastev, Jadwiga Nieminuszczy, John Alexander, Feifei Song, Malgorzata Dylewska, Ronan Broderick, Rachel Brough, Astrid Zimmermann, Frank T Zenke, Bora Gurel, Ruth Riisnaes, Ana Ferreira, Theodoros I Roumeliotis, Jyoti Sharma Choudhary, Stephen J Pettitt, Johann S de Bono, Andres Cervantes, Syed Haider, Wojciech Niedzwiedz, Christopher J Lord, Irene Y Chong
SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance. Cancer research 82 (21) (2022)
Violeta Serra, Anderson T Wang, Marta Castroviejo-Bermejo, Urszula M Polanska, Marta Palafox, Andrea Herencia-Ropero, Gemma N Jones, Zhongwu Lai, Joshua Armenia, Filippos Michopoulos, Alba Llop-Guevara, Rachel Brough, Aditi Gulati, Stephen J Pettitt, Krishna C Bulusu, Jenni Nikkilä, Zena Wilson, Adina M Hughes, Paul W G Wijnhoven, Ambar Ahmed, Alejandra Bruna, Albert Gris-Oliver, Marta Guzman, Olga Rodríguez, Judit Grueso, Joaquín Arribas, Javier Cortes, Cristina Saura, Alan Lau, Susan E Critchlow, Brian Dougherty, Carlos Caldas, Gordon B Mills, J Carl Barrett, Josep V Forment, Elaine B Cadogan, Christopher J Lord, Cristina Cruz, Judith Balmaña, Lenka Oplustil O'Connor
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (20) (2022)
Dalia Tarantino, Callum Walker, Daniel Weekes, Helen Pemberton, Kathryn Davidson, Gonzalo Torga, Jessica Frankum, Ana M Mendes-Pereira, Cynthia Prince, Riccardo Ferro, Rachel Brough, Stephen J Pettitt, Christopher J Lord, Anita Grigoriadis, Andrew N J Tutt
Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance. Oncogene 41 (32) (2022)
Dragomir B Krastev, Shudong Li, Yilun Sun, Andrew J Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M Badder, Eleanor G Knight, Rebecca Marlow, Mercedes Calvo Pardo, Lu Yu, Tanaji T Talele, Jiri Bartek, Jyoti Sharma Choudhary, Yves Pommier, Stephen J Pettitt, Andrew N J Tutt, Kristijan Ramadan, Christopher J Lord
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin. Nature cell biology 24 (1) (2022)
Diana Zatreanu, Helen M R Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A Heald, Sophie Langdon, Jayesh Majithiya, Claire L McWhirter, Niall M B Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M Badder, Daniela Novo, Eleanor G Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin E Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J Boulton, Geoff S Higgins, Stephen J Pettitt, Graeme C M Smith, Christopher J Lord
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nature communications 12 (1) (2021)
Suzanne Carreira, Nuria Porta, Sara Arce-Gallego, George Seed, Alba Llop-Guevara, Diletta Bianchini, Pasquale Rescigno, Alec Paschalis, Claudia Bertan, Chloe Baker, Jane Goodall, Susana Miranda, Ruth Riisnaes, Ines Figueiredo, Ana Ferreira, Rita Pereira, Mateus Crespo, Bora Gurel, Daniel Nava Rodrigues, Stephen J Pettitt, Wei Yuan, Violeta Serra, Jan Rekowski, Christopher J Lord, Emma C Hall, Joaquin Mateo, Johann S de Bono
Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial. Cancer discovery 11 (11) (2021)
Roman M Chabanon, Daphné Morel, Thomas Eychenne, Léo Colmet-Daage, Ilirjana Bajrami, Nicolas Dorvault, Marlène Garrido, Cornelia Meisenberg, Andrew Lamb, Carine Ngo, Suzanna R Hopkins, Theodoros I Roumeliotis, Samuel Jouny, Clémence Hénon, Asuka Kawai-Kawachi, Clémence Astier, Asha Konde, Elaine Del Nery, Christophe Massard, Stephen J Pettitt, Raphaël Margueron, Jyoti S Choudhary, Geneviève Almouzni, Jean-Charles Soria, Eric Deutsch, Jessica A Downs, Christopher J Lord, Sophie Postel-Vinay
PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer. Cancer research 81 (11) (2021)
Ilirjana Bajrami, Callum Walker, Dragomir B Krastev, Daniel Weekes, Feifei Song, Andrew J Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J Pettitt, Andrew N J Tutt, Christopher J Lord
Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency. Communications biology 4 (1) (2021)
Levani Zandarashvili, Marie-France Langelier, Uday Kiran Velagapudi, Mark A Hancock, Jamin D Steffen, Ramya Billur, Zain M Hannan, Andrew J Wicks, Dragomir B Krastev, Stephen J Pettitt, Christopher J Lord, Tanaji T Talele, John M Pascal, Ben E Black
Structural basis for allosteric PARP-1 retention on DNA breaks. Science (New York, N.Y.) 368 (6486) (2020)
Stephen J Pettitt, Jessica R Frankum, Marco Punta, Stefano Lise, John Alexander, Yi Chen, Timothy Anthony Yap, Syed Haider, Andrew N J Tutt, Christopher J Lord
Clinical BRCA1/2 Reversion Analysis Identifies Hotspot Mutations and Predicted Neoantigens Associated with Therapy Resistance. Cancer discovery 10 (10) (2020)
Timothy Anthony Yap, Rebecca S Kristeleit, Vasiliki Michalarea, Stephen J Pettitt, Joline S J Lim, Suzanne Carreira, Desamparados Roda, Rowan Miller, Ruth Riisnaes, Susana Miranda, Ines Figueiredo, Daniel Nava Rodrigues, Sarah Ward, Ruth Matthews, Mona Parmar, Alison Turner, Nina Tunariu, Neha Chopra, Heidrun Gevensleben, Nicholas C Turner, Ruth Ruddle, Florence I Raynaud, Shaun Decordova, Karen E Swales, Laura Finneran, Emma C Hall, Paul Rugman, Justin P O Lindemann, Andrew Foxley, Christopher J Lord, Udai Banerji, Ruth Plummer, Bristi Basu, Juanita S Lopez, Yvette Drew, Johann S de Bono
Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non-BRCA1/2-Mutant Cancers. Cancer discovery 10 (10) (2020)
Saira Khalique, Stephen J Pettitt, Ger Kelly, Nina Tunariu, Rachael Natrajan, Susana Banerjee, Christopher J Lord
Longitudinal analysis of a secondary BRCA2 mutation using digital droplet PCR. The journal of pathology. Clinical research 6 (1) (2019)
Harriett Holme, Aditi Gulati, Rachel Brough, Emmy D G Fleuren, Ilirjana Bajrami, James Campbell, Irene Y Chong, Sara Costa-Cabral, Richard Elliott, Tim R Fenton, Jessica Frankum, Samuel E Jones, Malini Menon, Rowan Miller, Helen N Pemberton, Sophie Postel-Vinay, Rumana Rafiq, Joanna L Selfe, Alex von Kriegsheim, Amaya Garcia Munoz, Javier Rodriguez, Janet Shipley, Winette T A van der Graaf, Chris T Williamson, Colm J Ryan, Stephen J Pettitt, Alan Ashworth, Sandra J Strauss, Christopher J Lord
Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness. Scientific reports 8 (1) (2018)
Harriett Holme, Aditi Gulati, Rachel Brough, Emmy D G Fleuren, Ilirjana Bajrami, James Campbell, Irene Y Chong, Sara Costa-Cabral, Richard Elliott, Tim R Fenton, Jessica Frankum, Samuel E Jones, Malini Menon, Rowan Miller, Helen N Pemberton, Sophie Postel-Vinay, Rumana Rafiq, Joanna L Selfe, Alex von Kriegsheim, Amaya Garcia Munoz, Javier Rodriguez, Janet Shipley, Winette T A van der Graaf, Chris T Williamson, Colm J Ryan, Stephen J Pettitt, Alan Ashworth, Sandra J Strauss, Christopher J Lord
Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness. Scientific reports 8 (1) (2018)
Rachel Brough, Aditi Gulati, Syed Haider, Rahul Kumar, James Campbell, Erik Knudsen, Stephen J Pettitt, Colm J Ryan, Christopher J Lord
Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer. Oncogene 37 (43) (2018)
Dragomir B Krastev, Stephen J Pettitt, James Campbell, Feifei Song, Barbara E Tanos, Stoyno S Stoynov, Alan Ashworth, Christopher J Lord
Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets. Nature communications 9 (1) (2018)
Stephen J Pettitt, Dragomir B Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J Lord
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. Nature communications 9 (1) (2018)

Stephen J Pettitt.css-eqlu8i{font-size:small;padding-left:4px;} (Stephen Pettit, Stephen Pettitt)

Publication Activity (10 Years)

Top Topics

Top Venues

Stephen J Pettitt (Stephen Pettit, Stephen Pettitt)