Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2.
Patrick C O'LearyHua-Dong ChenYagmur Umay DorukTess WilliamsonBenjamin J PolaccoAndrew S McNealTanushree ShenoyNupura KaleJulia CarnevaleErica StevensonDavid A QuigleyJonathan ChouFelix Y FengDanielle L SwaneyNevan J KroganMinkyu KimMorgan E DiolaitiAlan AshworthPublished in: Cancer research (2022)
Loss of NMD proteins promotes resistance to ATR inhibitors in gastric cancer cells, which may provide a combination of therapeutic targets and biomarkers to improve the clinical utility of these drugs.