Alan Ashworth

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 38

Top Venues

Science (New York, N.Y.)

Seminars in immunopathology

bioRxiv : the preprint server for biology

Cancer research communications

University of California San Francisco

University College London (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of California San Francisco Jan 01 2015

United States

President :: UCSF Helen Diller Family Comprehensive Cancer Center

Education History

University College London

United Kingdom

PHD :: Biochemistry

Publications

Daphne F Chen, Leah Tang Roe, Yuping Li, Adair L Borges, Jenny Y Zhang, Palak Babbar, Sourobh Maji, Maisie G V Stevens, Galen J Correy, Morgan E Diolati, Dominique H Smith, Alan Ashworth, Robert M Stroud, Mark J S Kelly, Joseph Bondy-Denomy, Brian K Shoichet
AcrIF11 is a potent CRISPR-specific ADP-ribosyltransferase encoded by phage and plasmid. bioRxiv : the preprint server for biology (2024)
Rahul K Suryawanshi, Priyadarshini Jaishankar, Galen J Correy, Moira M Rachman, Patrick C O'Leary, Taha Y Taha, Francisco J Zapatero-Belinchón, Maria McCavitt-Malvido, Yagmur Umay Doruk, Maisie G V Stevens, Morgan E Diolati, Manasi P Jogalekar, Alicia L Richards, Mauricio Montano, Julia Rosecrans, Michael A Matthay, Takaya Togo, Ryan L Gonciarz, Saumya Gopalkrishnan, R Jeffrey Neitz, Nevan J Krogan, Danielle L Swaney, Brian K Shoichet, Melanie M Ott, Adam R Renslo, Alan Ashworth, Brian K Shoichet
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2. bioRxiv : the preprint server for biology (2024)
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E Diolati, Alan Ashworth, Nicholas F Polizzi, William F DeGrado
De novo design of drug-binding proteins with predictable binding energy and specificity. Science (New York, N.Y.) 384 (6691) (2024)
Edward B Maldonado, W Kimryn Rathmell, Geoffrey I Shapiro, Naoko Takebe, Jordi Rodon Ahnert, Devalingam Mahalingam, Nikolaos A Trikalinos, Arash Rezazadeh Kalebasty, Mamta Parikh, Scott A Boerner, Celene Balido, Gregor Krings, Timothy F Burns, Emily K Bergsland, Pamela N Munster, Alan Ashworth, Patricia M LoRusso, Rahul R Aggarwal
A Phase II Trial of the WEE1 Inhibitor Adavosertib in SETD2-Altered Advanced Solid Tumor Malignancies (NCI 10170). Cancer research communications 4 (7) (2024)
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E Diolati, Alan Ashworth, Nicholas F Polizzi, William F DeGrado
De novo design of drug-binding proteins with predictable binding energy and specificity. Science (New York, N.Y.) 384 (6691) (2024)
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E Diolati, Alan Ashworth, Nicholas F Polizzi, William F DeGrado
De novo design of drug-binding proteins with predictable binding energy and specificity. Science (New York, N.Y.) 384 (6691) (2024)
Abrar Choudhury, Martha A Cady, Calixto-Hope G Lucas, Hinda Najem, Joanna J Phillips, Brisa Palikuqi, Naomi Zakimi, Tara Joseph, Janeth Ochoa Birrueta, William C Chen, Nancy Ann Oberheim Bush, Shawn L Hervey-Jumper, Ophir D Klein, Christine M Toedebusch, Craig M Horbinski, Stephen T Magill, Aparna Bhaduri, Arie Perry, Peter J Dickinson, Amy B Heimberger, Alan Ashworth, Elizabeth E Crouch, David R Raleigh
Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy. Cancer discovery (2024)
Edward B Maldonado, W Kimryn Rathmell, Geoffrey I Shapiro, Naoko Takebe, Jordi Rodon Ahnert, Devalingam Mahalingam, Nikolaos A Trikalinos, Arash Rezazadeh Kalebasty, Mamta Parikh, Scott A Boerner, Celene Balido, Gregor Krings, Timothy F Burns, Emily K Bergsland, Pamela N Munster, Alan Ashworth, Patricia M LoRusso, Rahul R Aggarwal
A Phase II Trial of the WEE1 Inhibitor Adavosertib in SETD2-Altered Advanced Solid Tumor Malignancies (NCI 10170). Cancer research communications 4 (7) (2024)
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E Diolati, Alan Ashworth, Nicholas F Polizzi, William F DeGrado
De novo design of drug-binding proteins with predictable binding energy and specificity. Science (New York, N.Y.) 384 (6691) (2024)
Rahul K Suryawanshi, Priyadarshini Jaishankar, Galen J Correy, Moira M Rachman, Patrick C O'Leary, Taha Y Taha, Francisco J Zapatero-Belinchón, Maria McCavitt-Malvido, Yagmur Umay Doruk, Maisie G V Stevens, Morgan E Diolati, Manasi P Jogalekar, Alicia L Richards, Mauricio Montano, Julia Rosecrans, Michael A Matthay, Takaya Togo, Ryan L Gonciarz, Saumya Gopalkrishnan, R Jeffrey Neitz, Nevan J Krogan, Danielle L Swaney, Brian K Shoichet, Melanie M Ott, Adam R Renslo, Alan Ashworth, Brian K Shoichet
The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2. bioRxiv : the preprint server for biology (2024)
Abrar Choudhury, Martha A Cady, Calixto-Hope G Lucas, Hinda Najem, Joanna J Phillips, Brisa Palikuqi, Naomi Zakimi, Tara Joseph, Janeth Ochoa Birrueta, William C Chen, Nancy Ann Oberheim Bush, Shawn L Hervey-Jumper, Ophir D Klein, Christine M Toedebusch, Craig M Horbinski, Stephen T Magill, Aparna Bhaduri, Arie Perry, Peter J Dickinson, Amy B Heimberger, Alan Ashworth, Elizabeth E Crouch, David R Raleigh
Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy. Cancer discovery (2024)
Edward B Maldonado, W Kimryn Rathmell, Geoffrey I Shapiro, Naoko Takebe, Jordi Rodon Ahnert, Devalingam Mahalingam, Nikolaos A Trikalinos, Arash Rezazadeh Kalebasty, Mamta Parikh, Scott A Boerner, Celene Balido, Gregor Krings, Timothy F Burns, Emily K Bergsland, Pamela N Munster, Alan Ashworth, Patricia M LoRusso, Rahul R Aggarwal
A Phase II Trial of the WEE1 Inhibitor Adavosertib in SETD2-Altered Advanced Solid Tumor Malignancies (NCI 10170). Cancer research communications 4 (7) (2024)
Abrar Choudhury, Martha A Cady, Calixto-Hope G Lucas, Hinda Najem, Joanna J Phillips, Brisa Palikuqi, Naomi Zakimi, Tara Joseph, Janeth Ochoa Birrueta, William C Chen, Nancy Ann Oberheim Bush, Shawn L Hervey-Jumper, Ophir D Klein, Christine M Toedebusch, Craig M Horbinski, Stephen T Magill, Aparna Bhaduri, Arie Perry, Peter J Dickinson, Amy B Heimberger, Alan Ashworth, Elizabeth E Crouch, David R Raleigh
Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy. Cancer discovery (2024)
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E Diolati, Alan Ashworth, Nicholas F Polizzi, William F DeGrado
De novo design of drug-binding proteins with predictable binding energy and specificity. Science (New York, N.Y.) 384 (6691) (2024)
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E Diolati, Alan Ashworth, Nicholas F Polizzi, William F DeGrado
De novo design of drug-binding proteins with predictable binding energy and specificity. Science (New York, N.Y.) 384 (6691) (2024)
Galen J Correy, Moira M Rachman, Takaya Togo, Stefan Gahbauer, Yagmur Umay Doruk, Maisie G V Stevens, Priyadarshini Jaishankar, Brian Kelley, Brian Goldman, Molly Schmidt, Trevor Kramer, Alan Ashworth, Patrick F Riley, Brian K Shoichet, Adam R Renslo, W Patrick Walters, Brian K Shoichet
Extensive exploration of structure activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment merging and active learning. bioRxiv : the preprint server for biology (2024)
Edward B Maldonado, W Kimryn Rathmell, Geoffrey I Shapiro, Naoko Takebe, Jordi Rodon Ahnert, Devalingam Mahalingam, Nikolaos A Trikalinos, Arash Rezazadeh Kalebasty, Mamta Parikh, Scott A Boerner, Celene Balido, Gregor Krings, Timothy F Burns, Emily K Bergsland, Pamela N Munster, Alan Ashworth, Patricia M LoRusso, Rahul R Aggarwal
A Phase II Trial of the WEE1 Inhibitor Adavosertib in SETD2-Altered Advanced Solid Tumor Malignancies (NCI 10170). Cancer research communications (2024)
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E Diolati, Alan Ashworth, Nicholas F Polizzi, William F DeGrado
De novo design of drug-binding proteins with predictable binding energy and specificity. Science (New York, N.Y.) 384 (6691) (2024)
Abrar Choudhury, Martha A Cady, Calixto-Hope G Lucas, Hinda Najem, Joanna J Phillips, Brisa Palikuqi, Naomi Zakimi, Tara Joseph, Janeth Ochoa Birrueta, William C Chen, Nancy Ann Oberheim Bush, Shawn L Hervey-Jumper, Ophir D Klein, Christine M Toedebusch, Craig M Horbinski, Stephen T Magill, Aparna Bhaduri, Arie Perry, Peter J Dickinson, Amy B Heimberger, Alan Ashworth, Elizabeth E Crouch, David R Raleigh
Perivascular NOTCH3+ stem cells drive meningioma tumorigenesis and resistance to radiotherapy. Cancer discovery (2024)
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Xiaofang Zhong, Dimitrios Gazgalis, Jesús Valdiviezo, Hyunil Jo, Yibing Wu, Morgan E Diolati, Alan Ashworth, Nicholas F Polizzi, William F DeGrado
De novo design of drug-binding proteins with predictable binding energy and specificity. Science (New York, N.Y.) 384 (6691) (2024)
Ionut-Gabriel Funingana, Jacob S Bedia, Ying-Wen Huang, Antonio Delgado Gonzalez, Kenyi Donoso, Veronica D Gonzalez, James D Brenton, Alan Ashworth, Wendy J Fantl
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors. Seminars in immunopathology 45 (1) (2023)
Ionut-Gabriel Funingana, Jacob S Bedia, Ying-Wen Huang, Antonio Delgado Gonzalez, Kenyi Donoso, Veronica D Gonzalez, James D Brenton, Alan Ashworth, Wendy J Fantl
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors. Seminars in immunopathology 45 (1) (2023)
Divneet Mandair, Jorge Sergio Reis-Filho, Alan Ashworth
Biological insights and novel biomarker discovery through deep learning approaches in breast cancer histopathology. NPJ breast cancer 9 (1) (2023)
Ionut-Gabriel Funingana, Jacob S Bedia, Ying-Wen Huang, Antonio Delgado Gonzalez, Kenyi Donoso, Veronica D Gonzalez, James D Brenton, Alan Ashworth, Wendy J Fantl
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors. Seminars in immunopathology 45 (1) (2023)
Ionut-Gabriel Funingana, Jacob S Bedia, Ying-Wen Huang, Antonio Delgado Gonzalez, Kenyi Donoso, Veronica D Gonzalez, James D Brenton, Alan Ashworth, Wendy J Fantl
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors. Seminars in immunopathology 45 (1) (2023)
Ionut-Gabriel Funingana, Jacob S Bedia, Ying-Wen Huang, Antonio Delgado Gonzalez, Kenyi Donoso, Veronica D Gonzalez, James D Brenton, Alan Ashworth, Wendy J Fantl
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors. Seminars in immunopathology 45 (1) (2023)
Ionut-Gabriel Funingana, Jacob S Bedia, Ying-Wen Huang, Antonio Delgado Gonzalez, Kenyi Donoso, Veronica D Gonzalez, James D Brenton, Alan Ashworth, Wendy J Fantl
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors. Seminars in immunopathology (2023)
Patrick C O'Leary, Hua-Dong Chen, Yagmur Umay Doruk, Tess Williamson, Benjamin J Polacco, Andrew S McNeal, Tanushree Shenoy, Nupura Kale, Julia Carnevale, Erica Stevenson, David A Quigley, Jonathan Chou, Felix Y Feng, Danielle L Swaney, Nevan J Krogan, Minkyu Kim, Morgan E Diolati, Alan Ashworth
Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2. Cancer research 82 (21) (2022)
Galen J Correy, Daniel W Kneller, Gwyndalyn Phillips, Swati Pant, Silvia Russi, Aina E Cohen, George Meigs, James M Holton, Stefan Gahbauer, Michael C Thompson, Alan Ashworth, Leighton Coates, Andrey Y Kovalevsky, Flora Meilleur, Brian K Shoichet
The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Science advances 8 (21) (2022)
Jonathan Chou, Emily A Egusa, Sinan Wang, Michelle L Badura, Fei Lee, Anil Parsram Bidkar, Jun Zhu, Tanushree Shenoy, Kai Trepka, Troy M Robinson, Veronica Steri, Jiaoti Huang, Yuzhuo Z Wang, Eric J Small, Emily Chan, Bradley A Stohr, Alan Ashworth, Brant Delafontaine, Sylvie Rottey, Keegan S Cooke, Nooshin Hashemi Sadraei, Brian Yu, Mark Salvati, Julie M Bailis, Felix Y Feng, Robert Richard Flavell, Rahul R Aggarwal
Immunotherapeutic targeting and PET imaging of DLL3 in small cell neuroendocrine prostate cancer. Cancer research (2022)
Anish Thomas, Shaun D Fontaine, Morgan E Diolati, Parth Desai, Rajesh Kumar, Nobuyuki Takahashi, Linda Sciuto, Samantha Nichols, Alan Ashworth, Felix Y Feng, Gary W Ashley, Minh Nguyen, Yves Pommier, Daniel V Santi
PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors. Molecular cancer therapeutics 21 (11) (2022)
Julia Carnevale, Eric Shifrut, Nupura Kale, William A Nyberg, Franziska Blaeschke, Yan Yi Chen, Zhongmei Li, Sagar P Bapat, Morgan E Diolati, Patrick C O'Leary, Shane Vedova, Julia A Belk, Bence Daniel, Theodore L Roth, Stefanie Bachl, Alejandro Allo Anido, Brooke Prinzing, Jorge Ibañez-Vega, Shannon Lange, Dalia Haydar, Marie Luetke-Eversloh, Maelys Born-Bony, Bindu Hegde, Scott C Kogan, Tobias Feuchtinger, Hideho Okada, Ansuman T Satpathy, Kevin Shannon, Stephen Gottschalk, Justin Eyquem, Giedre Krenciute, Alan Ashworth, Alexander Marson
RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature 609 (7925) (2022)
Hua-Dong Chen, Morgan E Diolati, Patrick C O'Leary, Ajda Rojc, Nevan J Krogan, Minkyu Kim, Alan Ashworth
A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor. Molecular cancer therapeutics 21 (7) (2022)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2. bioRxiv : the preprint server for biology (2022)
Martin Sjostrom, Shuang G Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha, Arian Lundberg, Cameron Herberts, Adam Foye, Rahul R Aggarwal, Junjie T Hua, Haolong Li, Anna Bergamaschi, Corinne Maurice-Dror, Ashutosh Maheshwari, Sujun Chen, Sarah W S Ng, Michael Fraser, Jessica Petricca, Michael Fraser, Lisa Chesner, Marc D Perry, Thaidy Moreno-Rodriguez, William S Chen, Joshi J Alumkal, Jonathan Chou, Alicia K Morgans, Tomasz M Beer, George V Thomas, Martin Gleave, Paul Lloyd, Tierney Phillips, Erin McCarthy, Michael C Haffner, Amina Zoubeidi, Matti Annala, Robert E Reiter, Matthew B Rettig, Owen N Witte, Lawrence Fong, Rohit Bose, Franklin W Huang, Joshua M Lang, Anders Bjartell, Nupam P Mahajan, Primo N Lara, Christopher P Evans, Phuoc T Tran, Edwin M Posadas, Chuan He, Xiao-Long Cui, Jiaoti Huang, Wilbert Zwart, Luke A Gilbert, Christopher A Maher, Paul C Boutros, Kim N Chi, Alan Ashworth, Eric J Small, Housheng Hansen He, Alexander W Wyatt, David A Quigley, Felix Y Feng
The 5-Hydroxymethylcytosine Landscape of Prostate Cancer. Cancer research 82 (21) (2022)
Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J McGregor, Patrick C O'Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique C Mitchell, Kari A Herrington, Denise P Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F Kreisberg, Morgan E Diolati, John D Gordan, Jean-Philippe Coppé, Danielle L Swaney, Bing Xia, Laura van 't Veer, Alan Ashworth, Trey Ideker, Nevan J Krogan
A protein interaction landscape of breast cancer. Science (New York, N.Y.) 374 (6563) (2021)
Marion Schuller, Galen J Correy, Stefan Gahbauer, Daren Fearon, Taiasean Wu, Roberto Efraín Díaz, Iris D Young, Luan Carvalho Martins, Dominique H Smith, Ursula Schulze-Gahmen, Tristan W Owens, Ishan Deshpande, Gregory E Merz, Aye C Thwin, Justin T Biel, Jessica K Peters, Michelle Moritz, Nadia Herrera, Huong T Kratochvil, null null, Anthony Aimon, James M Bennett, José Brandão-Neto, Aina E Cohen, Alexandre Dias, Alice Douangamath, Louise Dunnett, Oleg Fedorov, Matteo P Ferla, Martin R Fuchs, Tyler J Gorrie-Stone, James M Holton, Michael G Johnson, Tobias Krojer, George Meigs, Ailsa J Powell, Johannes Gregor Matthias Rack, Victor L Rangel, Silvia Russi, Rachael E Skyner, Clyde A Smith, Alexei S Soares, Jennifer L Wierman, Kang Zhu, Peter O'Brien, Natalia Jura, Alan Ashworth, John J Irwin, Michael C Thompson, Jason E Gestwicki, Frank von Delft, Brian K Shoichet, Brian K Shoichet, Ivan Ahel
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science advances 7 (16) (2021)
Christopher J Lord, Alan Ashworth
PARP inhibitors: Synthetic lethality in the clinic. Science (New York, N.Y.) 355 (6330) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Alan Ashworth