Aqueous Extract of Brazilian Berry (Myrciaria jaboticaba) Peel Improves Inflammatory Parameters and Modulates Lactobacillus and Bifidobacterium in Rats with Induced-Colitis.
Juliana Kelly da Silva-MaiaÂngela Giovana BatistaCinthia Baú Betim CazarinEdilene Siqueira SoaresStanislau BoguszRaquel Franco LealMaria Alice da Cruz-HöflingMário Roberto MarósticaPublished in: Nutrients (2019)
Natural compounds could be a complementary alternative to inflammatory bowel disease (IBD) management. This study determined the effects of an aqueous extract of Myrciaria jaboticaba peel (EJP) (50 g L-1) on 2,4,6-trinitrobenzenesulfonic acid-induced colitis. Wistar rats were randomized into five groups: HC-healthy control, CC-colitis control, DC-drug control, SJ-short-term treatment with EJP, and LJ-long-term treatment with EJP. The EJP treatments reduced body weight loss, stool consistency score, and spleen enlargement. Gut microbiota was modulated through increased Lactobacillus and Bifidobacterium counts after EJP treatment. Short-chain fatty acids were also higher in the EJP treatment groups. The antioxidant enzyme activities were greater than CC or DC controls. Myeloperoxidase activity (LJ), inducible nitric oxide synthase (LJ/SJ), and intercellular adhesion molecule (SJ) levels were lower than in the CC group. EJP decreased histological scoring, mucosal thickness, and preserved the crypts and histological structure. Therefore, EJP showed beneficial effects and could be potentially used as an adjuvant in IBD treatment.
Keyphrases
- oxidative stress
- nitric oxide
- nitric oxide synthase
- type diabetes
- randomized controlled trial
- clinical trial
- bariatric surgery
- early stage
- fatty acid
- staphylococcus aureus
- combination therapy
- ulcerative colitis
- anti inflammatory
- open label
- double blind
- rheumatoid arthritis
- cystic fibrosis
- systemic lupus erythematosus
- ionic liquid
- peripheral blood
- weight gain