One-Year Effects of High-Intensity Statin on Bioactive Lipids: Findings From the JUPITER Trial.
Rosangela Akemi HoshiMona AlotaibiYanyan LiuJeramie D WatrousPaul M RidkerRobert J GlynnCharles Nicholas SerhanHeike Luttmann-GibsonM Vinayaga MoorthyMohit JainDemler V OlgaSamia MoraPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Statin allocation was significantly associated with upregulation of BALs with anti-inflammatory, antiplatelet aggregation and antioxidant properties and downregulation of BALs with proinflammatory and proplatelet aggregation activity, supporting the pleiotropic effects of statins beyond low-density lipoprotein cholesterol reduction.
Keyphrases
- high intensity
- anti inflammatory
- cardiovascular disease
- cell proliferation
- resistance training
- coronary artery disease
- signaling pathway
- low density lipoprotein
- study protocol
- oxidative stress
- clinical trial
- phase iii
- phase ii
- poor prognosis
- randomized controlled trial
- type diabetes
- fatty acid
- double blind
- placebo controlled