A guideline on the molecular ecosystem regulating ferroptosis.
Enyong DaiXin ChenAndreas LinkermannXuejun JiangRui KangValerian E KaganHülya BayirWan Seok YangAna J Garcia-SaezMaria S IoannouTobias JanowitzQitao RanWei GuBoyi GanDmitri V KryskoXiao-Feng ZhuJiayi WangStefan KrautwaldShinya ToyokuniYangchun XieFlorian R GretenQing YiJoel A SchickJiao LiuDmitry I GabrilovichJin-Bao LiuHerbert J ZehDonna D ZhangMinghua YangJuan IovannaManfred KopfTimon Erik AdolphJen-Tsan ChiChangfeng LiHidenori IchijoMichael KarinVijay G SankaranWeiping ZouLorenzo GalluzziAshley I BushBinghui LiGerry MelinoEric H BaehreckeMichael T LotzeDaniel J KlionskyBrent R StockwellGuido KroemerDaolin TangPublished in: Nature cell biology (2024)
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.