MitoQ Prevents Human Breast Cancer Recurrence and Lung Metastasis in Mice.
Tania CapeloaJoanna KrzystyniakAmanda Canas RodriguezValéry L PayenLuca X ZampieriErica PranziniFrançoise DerouaneThibaut VazeilleCaroline BouzinFran Ois P DuhouxMichael P MurphyPaolo Ettore PorporatoPierre SonveauxPublished in: Cancers (2022)
In oncology, the occurrence of distant metastases often marks the transition from curative to palliative care. Such outcome is highly predictable for breast cancer patients, even if tumors are detected early, and there is no specific treatment to prevent metastasis. Previous observations indicated that cancer cell mitochondria are bioenergetic sensors of the tumor microenvironment that produce superoxide to promote evasion. Here, we tested whether mitochondria-targeted antioxidant MitoQ is capable to prevent metastasis in the MDA-MB-231 model of triple-negative human breast cancer in mice and in the MMTV-PyMT model of spontaneously metastatic mouse breast cancer. At clinically relevant doses, we report that MitoQ not only prevented metastatic take and dissemination, but also local recurrence after surgery. We further provide in vitro evidence that MitoQ does not interfere with conventional chemotherapies used to treat breast cancer patients. Since MitoQ already successfully passed Phase I safety clinical trials, our preclinical data collectively provide a strong incentive to test this drug for the prevention of cancer dissemination and relapse in clinical trials with breast cancer patients.
Keyphrases
- clinical trial
- palliative care
- endothelial cells
- squamous cell carcinoma
- small cell lung cancer
- free survival
- pluripotent stem cells
- induced pluripotent stem cells
- cell death
- high fat diet induced
- advanced cancer
- oxidative stress
- risk assessment
- stem cells
- papillary thyroid
- lymph node
- randomized controlled trial
- rectal cancer
- reactive oxygen species
- hydrogen peroxide
- electronic health record
- machine learning
- emergency department
- adipose tissue
- cell proliferation
- signaling pathway
- drug delivery
- mouse model
- open label
- data analysis
- smoking cessation
- big data
- low cost
- artificial intelligence
- drug induced
- replacement therapy
- anti inflammatory
- prognostic factors