Dietary choline increases brown adipose tissue activation markers and improves cholesterol metabolism in female APOE*3-Leiden.CETP mice.
Cong LiuZikuan SongZhuang LiMariëtte R BoonMilena SchönkePatrick C N RensenYanan WangPublished in: International journal of obesity (2005) (2023)
In APOE*3-Leiden.CETP mice, dietary choline reduces body fat by enhancing TRL-derived fatty acids by BAT, resulting in accelerated TRL turnover to improve hypercholesterolemia. These data provide a mechanistic basis for the observation in human intervention trials that high choline intake is linked with reduced body weight.
Keyphrases
- body weight
- adipose tissue
- high fat diet
- high fat diet induced
- fatty acid
- cognitive decline
- endothelial cells
- randomized controlled trial
- insulin resistance
- electronic health record
- big data
- type diabetes
- bone mineral density
- induced pluripotent stem cells
- wild type
- coronary artery disease
- pluripotent stem cells
- skeletal muscle
- weight loss