Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization.

Kehong ZhangPaul Mike JordanSimona PaceRobert Klaus HofstetterMarkus WernerXinchun ChenOliver Werz

Published in: Journal of inflammation research (2022)

Depending on the timing and concentration, CS not only favorably affects LOX activities in macrophages but also the expression of LM-biosynthetic enzymes during macrophage polarization connected to changes of inflammation-related LM which might be of relevance for potential application of CS to treat inflammatory disorders.

Keyphrases

oxidative stress
endothelial cells
poor prognosis
induced pluripotent stem cells
binding protein
fatty acid
long non coding rna
human health
pluripotent stem cells