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Expression of T-Cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma.

Miriam FicialOpeyemi A JagedeMiriam Sant'AngeloYue HouAbdallah FlaifelJean-Christophe PignonDavid A BraunMegan Wind-RotoloMaura A Sticco-IvinsPaul J CatalanoGordon J FreemanArlene H SharpeF Stephen HodiRobert J MotzerCatherine J WuMichael B AtkinsDavid F McDermottSachet A ShuklaToni K ChoueiriSabina Signoretti
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
High levels of CD8+ TIC expressing PD-1 but not TIM-3 and LAG-3 and ERVE-4 expression predicted response to nivo (but not to evero) in patients with mccRCC. Combination of the IF biomarker with TC PD-L1 improved its predictive value, confirming our previous findings.
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