Chemical Compositions, Antiobesity, and Antioxidant Effects of Proanthocyanidins from Lotus Seed Epicarp and Lotus Seed Pot.
Jialing CaoXiuliang YuZe-Yuan DengYao PanBing ZhangRong TsaoHong-Yan LiPublished in: Journal of agricultural and food chemistry (2018)
Lotus seed epicarp (LSE) and lotus seed pot (LSP) were characterized, and a total of 5 and 7 proanthocyanidins (PAs) were identified in purified LSE and LSP extract, respectively. Purified LSE and LSP PAs significantly suppressed the body weight and weight gain of white adipose tissue (WAT) and decreased the WAT cell size in high-fat diet-induced obese mice regardless of the daily food intake. LSE or LSP administration significantly lowered the serum leptin level and improved the serum and liver lipid profiles (including total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) levels), increased activities of antioxidant enzymes (superoxide dismutase (SOD) and glutathione transferase (GST)) and reduced glutathione (GSH) concentration, and suppressed lipid peroxidation in hepatic tissue. LSP PAs were generally more effective than LSE PAs. Both extracts ameliorated obesity, insulin resistance, and oxidative damage in obese mice, suggesting they are good candidates for value-added functional food and nutraceutical ingredients.
Keyphrases
- insulin resistance
- high fat diet induced
- weight gain
- adipose tissue
- body weight
- high fat diet
- oxidative stress
- metabolic syndrome
- polycystic ovary syndrome
- type diabetes
- body mass index
- skeletal muscle
- anti inflammatory
- birth weight
- weight loss
- physical activity
- fatty acid
- single cell
- low density lipoprotein
- stem cells
- mesenchymal stem cells
- glycemic control
- preterm birth
- human health
- bone marrow