Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer.
Katey S S EnfieldEmma C ColliverClaudia S Y LeeAlastair MagnessDavid Allan MooreMonica SivakumarKristiana GrigoriadisOriol PichTakahiro KarasakiPhilip S HobsonDina LeviSelvaraju VeeriahClare PuttickEmma L NyeMary GreenKrijn K DijkstraMasako ShimatoAyse U AkarcaTeresa MarafiotiRoberto SalgadoAllan Hackshawnull nullMariam Jamal-HanjaniFebe van MaldegemNicholas McGranahanBenjamin GlassHanna PulaskiEric WalkJames L ReadingSergio A QuezadaCrispin T HileyJulian DownwardErik SahaiCharles SwantonMihaela AngelovaPublished in: Cancer discovery (2024)
This study provides novel insights into the spatial organization of the lung cancer TME in the context of tumor immunogenicity, tumor heterogeneity, and cancer evolution. Pairing the tumor evolutionary history with the spatially resolved TME suggests mechanistic hypotheses for tumor progression and metastasis with implications for patient outcome and treatment. This article is featured in Selected Articles from This Issue, p. 897.