Julian Downward

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 55

Top Venues

Nature communications

Nature protocols

Cancer research

Cancer discovery

Francis Crick Institute

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Francis Crick Institute Apr 01 2015

United Kingdom

Associate Reaearch Director

Cancer Research UK London Research Institute Oct 01 1989 - Mar 31 2015

United Kingdom

Group leader, Associate Director

Publications

Alastair Magness, Emma C Colliver, Katey S S Enfield, Claudia S Y Lee, Masako Shimato, Emer Daly, David Allan Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T Hiley, Philip S Hobson, Febe van Maldegem, James L Reading, Sergio A Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX. Nature communications 15 (1) (2024)
Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Mona Tomaschko, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Philip East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward
CRISPR-Cas9 screening identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer. Cancer research (2024)
Alastair Magness, Emma C Colliver, Katey S S Enfield, Claudia S Y Lee, Masako Shimato, Emer Daly, David Allan Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T Hiley, Philip S Hobson, Febe van Maldegem, James L Reading, Sergio A Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX. Nature communications 15 (1) (2024)
Cory A Ocasio, Marc P Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M Storck, Jack W Houghton, Susana A Palma-Duran, James I MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S Eggert, Edward William Tate
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature biotechnology (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, null null, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery 14 (6) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, null null, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery 14 (6) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, null null, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery 14 (6) (2024)
Matthew D Park, Jessica Le Berichel, Pauline Hamon, C Matthias Wilk, Meriem Belabed, Nader Yatim, Alexis Saffon, Jesse Boumelha, Chiara Falcomatà, Alexander Tepper, Samarth Hegde, Raphaël Mattiuz, Brian Y Soong, Nelson M LaMarche, Frederika Rentzeperis, Leanna Troncoso, Laszlo Halasz, Clotilde Hennequin, Theodore Chin, Earnest P Chen, Amanda M Reid, Matthew Su, Ashley Reid Cahn, Laura L Koekkoek, Nicholas Venturini, Shira Wood-Isenberg, Darwin D'souza, Rachel Chen, Travis Dawson, Kai Nie, Zhihong Chen, Seunghee Kim-Schulze, María Casanova-Acebes, Filip K Swirski, Julian Downward, Nicolas Vabret, Brian D Brown, Thomas U Marron, Miriam Merad
Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis. Science (New York, N.Y.) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Cory A Ocasio, Marc P Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M Storck, Jack W Houghton, Susana A Palma-Duran, James I MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S Eggert, Edward William Tate
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature biotechnology (2024)
Alastair Magness, Emma C Colliver, Katey S S Enfield, Claudia S Y Lee, Masako Shimato, Emer Daly, David Allan Moore, Monica Sivakumar, Karishma Valand, Dina Levi, Crispin T Hiley, Philip S Hobson, Febe van Maldegem, James L Reading, Sergio A Quezada, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX. Nature communications 15 (1) (2024)
Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Mona Tomaschko, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Philip East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward
CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer. Cancer research 84 (14) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, TRACERx Consortium, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, null null, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery 14 (6) (2024)
Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Mona Tomaschko, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Philip East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward
CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer. Cancer research 84 (14) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Cory A Ocasio, Marc P Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M Storck, Jack W Houghton, Susana A Palma-Duran, James I MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S Eggert, Edward William Tate
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature biotechnology (2024)
Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Mona Tomaschko, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Philip East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward
CRISPR-Cas9 Screening Identifies KRAS-Induced COX2 as a Driver of Immunotherapy Resistance in Lung Cancer. Cancer research 84 (14) (2024)
Kevin W Ng, Jesse Boumelha, Katey S S Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A Moore, Roberto Salgado, Monica Sivakumar, George R Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fendler, Lewis Au, Scott T C Shepherd, Carlos Martínez-Ruiz, Clare Puttick, James R M Black, Thomas B K Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulkner, Jan Attig, Selvaraju Veeriah, Neil Magno, Sophia Ward, Alexander M Frankell, Maise Al Bakir, Emilia L Lim, Mark S Hill, Gareth A Wilson, Daniel E Cook, Nicolai Juul Birkbak, Axel Behrens, Nadia Yousaf, Sanjay Popat, Allan Hackshaw, null null, null null, Crispin T Hiley, Kevin Litchfield, Nicholas McGranahan, Mariam Jamal-Hanjani, James Larkin, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward, George Kassiotis
Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature (2023)
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
Addendum: Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature protocols (2023)
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
Addendum: Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature protocols (2023)
Jitesh Chauhan, Melanie Grandits, Lais C G F Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A Lionarons, Hannah J Gould, Andrew J Beavil, Jenny L C Geh, Alastair D MacKenzie-Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O Nestle, Sophia Tsoka, Debra H Josephs, Philip J Blower, Panagiotis Karagiannis, Katie E Lacy, James F Spicer, Sophia N Karagiannis, Heather J Bax
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4. Nature communications 14 (1) (2023)
William Hill, Emilia L Lim, Clare E Weeden, Claudia S Y Lee, Marcellus Augustine, Kezhong Chen, Feng-Che Kuan, Fabio Marongiu, Edward J Evans, David Allan Moore, Felipe S Rodrigues, Oriol Pich, Bjorn Bakker, Hongui Cha, Renelle Myers, Febe van Maldegem, Jesse Boumelha, Selvaraju Veeriah, Andrew Rowan, Cristina Naceur-Lombardelli, Takahiro Karasaki, Monica Sivakumar, Swapnanil De, Deborah R Caswell, Ai Nagano, James R M Black, Carlos Martínez-Ruiz, Min Hyung Ryu, Ryan D Huff, Shijia Li, Marie-Julie Favé, Alastair Magness, Alejandro Suarez-Bonnet, Simon Lawrence Priestnall, Margreet Lüchtenborg, Katrina Lavelle, Joanna Pethick, Steven Hardy, Fiona E McRonald, Meng-Hung Lin, Clara I Troccoli, Moumita Ghosh, York E Miller, Daniel T Merrick, Robert L Keith, Maise Al Bakir, Chris Bailey, Mark S Hill, Lao H Saal, Yilun Chen, Anthony M George, Christopher Abbosh, Nnennaya Kanu, Se-Hoon Lee, Nicholas McGranahan, Christine D Berg, Peter D Sasieni, Richard S Houlston, Clare Turnbull, Stephen Lam, Phillip Awadalla, Eva Grönroos, Julian Downward, Tyler Jacks, Christopher Carlsten, Ilaria Malanchi, Allan Hackshaw, Kevin Litchfield, null null, James DeGregori, Mariam Jamal-Hanjani, Charles Swanton
Lung adenocarcinoma promotion by air pollutants. Nature 616 (7955) (2023)
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
Addendum: Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature protocols (2023)
Deborah R Caswell, Philippe Gui, Manasi K Mayekar, Emily K Law, Oriol Pich, Chris Bailey, Jesse Boumelha, D Lucas Kerr, Collin M Blakely, Tadashi Manabe, Carlos Martinez-Ruiz, Bjorn Bakker, Juan De Dios Palomino Villcas, Natalie I Vokes, Michelle Dietzen, Mihaela Angelova, Beatrice Gini, Whitney Tamaki, Paul Allegakoen, Wei Wu, Timothy J Humpton, William Hill, Mona Tomaschko, Wei-Ting Lu, Franziska Haderk, Maise Al Bakir, Ai Nagano, Francisco Gimeno-Valiente, Sophie de Carné Trécesson, Roberto Vendramin, Vittorio Barbè, Miriam Mugabo, Clare E Weeden, Andrew Rowan, Caroline E McCoach, Bruna Almeida, Mary Green, Carlos Gomez, Shigeki Nanjo, Dora Barbosa, Chris Moore, Joanna Przewrocka, James R M Black, Eva Grönroos, Alejandro Suarez-Bonnet, Simon Lawrence Priestnall, Caroline Zverev, Scott Lighterness, James Cormack, Victor Olivas, Lauren Cech, Trisha Andrews, Brandon Rule, Yuwei Jiao, Xinzhu Zhang, Paul Ashford, Cameron Durfee, Subramanian Venkatesan, Nuri Alpay Temiz, Lisa Tan, Lindsay K Larson, Prokopios P Argyris, William L Brown, Elizabeth A Yu, Julia K Rotow, Udayan Guha, Nitin Roper, Johnny Yu, Rachel Isaksson Vogel, Nicholas J Thomas, Antonio Marra, Pier Selenica, Helena Alexandra Yu, Samuel F Bakhoum, Su Kit Chew, Jorge Sergio Reis-Filho, Mariam Jamal-Hanjani, Karen H Vousden, Nicholas McGranahan, Eliezer Van Allen, Nnennaya Kanu, Reuben Stewart Harris, Julian Downward, Trever G Bivona, Charles Swanton
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance. Nature genetics (2023)
Jitesh Chauhan, Melanie Grandits, Lais C G F Palhares, Silvia Mele, Mano Nakamura, Jacobo López-Abente, Silvia Crescioli, Roman Laddach, Pablo Romero-Clavijo, Anthony Cheung, Chara Stavraka, Alicia M Chenoweth, Heng Sheng Sow, Giulia Chiaruttini, Amy E Gilbert, Tihomir Dodev, Alexander Koers, Giulia Pellizzari, Kristina M Ilieva, Francis Man, Niwa Ali, Carl Hobbs, Sara Lombardi, Daniël A Lionarons, Hannah J Gould, Andrew J Beavil, Jenny L C Geh, Alastair D MacKenzie-Ross, Ciaran Healy, Eduardo Calonje, Julian Downward, Frank O Nestle, Sophia Tsoka, Debra H Josephs, Philip J Blower, Panagiotis Karagiannis, Katie E Lacy, James F Spicer, Sophia N Karagiannis, Heather J Bax
Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4. Nature communications 14 (1) (2023)
Jesse Boumelha, Miriam Molina-Arcas, Julian Downward
Facts and hopes on RAS inhibitors and cancer immunotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Jesse Boumelha, Sophie de Carné Trécesson, Emily K Law, Pablo Romero-Clavijo, Matthew A Coelho, Kevin W Ng, Edurne Mugarza, Christopher Moore, Sareena Rana, Deborah R Caswell, Miguel Murillo, David C Hancock, Prokopios P Argyris, William L Brown, Cameron Durfee, Lindsay K Larson, Rachel Isaksson Vogel, Alejandro Suarez-Bonnet, Simon Lawrence Priestnall, Philip East, Sarah J Ross, George Kassiotis, Miriam Molina-Arcas, Charles Swanton, Reuben Stewart Harris, Julian Downward
An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations. Cancer research 82 (19) (2022)
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature protocols 18 (3) (2022)
Philip East, Gavin P Kelly, Dhruva Biswas, Michela Marani, David C Hancock, Todd Creasy, Kris Sachsenmeier, Charles Swanton, null null, Julian Downward, Sophie de Carné Trécesson
RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma. Nature communications 13 (1) (2022)
Edurne Mugarza, Febe van Maldegem, Jesse Boumelha, Christopher Moore, Sareena Rana, Miriam Llorian Sopena, Philip East, Rachel Ambler, Panayiotis Anastasiou, Pablo Romero-Clavijo, Karishma Valand, Megan Cole, Miriam Molina-Arcas, Julian Downward
Therapeutic KRAS G12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers. Science advances 8 (29) (2022)
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature protocols 18 (3) (2022)
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature protocols (2022)
May Zaw Thin, Christopher Moore, Thomas Snoeks, Tammy Kalber, Julian Downward, Axel Behrens
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice. Nature protocols 18 (3) (2022)
Miriam Molina-Arcas, Julian Downward
The Potency of a KRAS Silent Variant. The New England journal of medicine 386 (26) (2022)
Febe van Maldegem, Karishma Valand, Megan Cole, Harshil Patel, Mihaela Angelova, Sareena Rana, Emma C Colliver, Katey S S Enfield, Nourdine Bah, Gavin P Kelly, Victoria Siu Kwan Tsang, Edurne Mugarza, Christopher Moore, Philip Hobson, Dina Levi, Miriam Molina-Arcas, Charles Swanton, Julian Downward
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry. Nature communications 12 (1) (2021)
Ayse Ertay, Huiquan Liu, Dian Liu, Ping Peng, Charlotte Hill, Hua Xiong, David Hancock, Xianglin Yuan, Marcin R Przewloka, Mark Coldwell, Michael Howell, Paul Skipp, Rob M Ewing, Julian Downward, Yihua Wang
Correction: WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. Cell death & disease 12 (3) (2021)
Tereza Vaclova, Ursula Grazini, Lewis S C Ward, Daniel O'Neill, Aleksandra Markovets, Xiangning Huang, Juliann Chmielecki, Ryan Hartmaier, Kenneth S Thress, Paul D Smith, J Carl Barrett, Julian Downward, Elza C de Bruin
Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers. Nature communications 12 (1) (2021)
Stelios Chrysostomou, Rajat Roy, Filippo Prischi, Lucksamon Thamlikitkul, Kathryn L Chapman, Uwais Mufti, Robert L Peach, Laifeng Ding, David C Hancock, Christopher Moore, Miriam Molina-Arcas, Francesco Mauri, David James Pinato, Joel M Abrahams, Silvia Ottaviani, Castellano L, Georgios Giamas, Jennifer Pascoe, Devmini Moonamale, Sarah J Pirrie, Claire Gaunt, Lucinda Billingham, Neil M Steven, Michael Cullen, David Hrouda, Mathias Winkler, John Post, Philip Cohen, Seth J Salpeter, Vered Bar, Adi Zundelevich, Shay Golan, Dan Leibovici, Romain Lara, David R Klug, Sophia N Yaliraki, Mauricio Barahona, Yulan Wang, Julian Downward, J Mark Skehel, Maruf M U Ali, Michael J Seckl, Olivier E Pardo
Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer. Science translational medicine 13 (602) (2021)
Rachel Cooley, Neesha Kara, Ning Sze Hui, Jonathan Tart, Chloë Roustan, Roger George, David C Hancock, Brock F Binkowski, Keith V Wood, Mohamed Ismail, Julian Downward
Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets. Wellcome open research 5 (2020)
Davide Zecchin, Christopher Moore, Fanourios Michailidis, Stuart Horswell, Sareena Rana, Michael Howell, Julian Downward
Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer. EMBO molecular medicine 12 (8) (2020)
Miriam Molina-Arcas, Christopher Moore, Sareena Rana, Febe van Maldegem, Edurne Mugarza, Pablo Romero-Clavijo, Eleanor Herbert, Stuart Horswell, Lian-Sheng Li, Matthew R Janes, David C Hancock, Julian Downward
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer. Science translational medicine 11 (510) (2020)
Sissy E Wamaitha, Katarzyna J Grybel, Gregorio Alanis-Lobato, Claudia Gerri, Sugako Ogushi, Afshan McCarthy, Shantha K Mahadevaiah, Lyn Healy, Rebecca A Lea, Miriam Molina-Arcas, Liani G Devito, Kay Elder, Phil Snell, Leila Christie, Julian Downward, James M A Turner, Kathy K Niakan
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche. Nature communications 11 (1) (2020)
Ayse Ertay, Huiquan Liu, Dian Liu, Ping Peng, Charlotte Hill, Hua Xiong, David Hancock, Xianglin Yuan, Marcin R Przewloka, Mark Coldwell, Michael Howell, Paul Skipp, Rob M Ewing, Julian Downward, Yihua Wang
WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. Cell death & disease 11 (11) (2020)
Yihua Wang, Hua Xiong, Dian Liu, Charlotte Hill, Ayse Ertay, Juanjuan Li, Yanmei Zou, Paul Miller, Eileen White, Julian Downward, Robert D Goldin, Xianglin Yuan, Xin Lu
Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy 15 (5) (2019)
Charlotte Hill, Juanjuan Li, Dian Liu, Franco Conforti, Christopher J Brereton, Liudi Yao, Yilu Zhou, Aiman Alzetani, Serena J Chee, Benjamin G Marshall, Sophie V Fletcher, David Hancock, Christian Hermann Ottensmeier, Andrew J Steele, Julian Downward, Luca Richeldi, Xin Lu, Donna E Davies, Mark G Jones, Yihua Wang
Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. Cell death & disease 10 (8) (2019)
Greg G Jones, Isabel Boned Del Río, Sibel Sari, Aysen Sekerim, Lucy C Young, Nicole Hartig, Itziar Areso Zubiaur, Mona A El-Bahrawy, Robert Edward Hynds, Winnie Lei, Miriam Molina-Arcas, Julian Downward, Pablo Rodriguez-Viciana
SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers. Nature communications 10 (1) (2019)
Hanna Foster, E Josue Ruiz, Christopher Moore, Gordon W H Stamp, Emma L Nye, Ningning Li, Yihang Pan, Yulong He, Julian Downward, Axel Behrens
ATMIN Is a Tumor Suppressor Gene in Lung Adenocarcinoma. Cancer research 79 (20) (2019)
Liudi Yao, Franco Conforti, Charlotte Hill, Joseph Bell, Leena Drawater, Juanjuan Li, Dian Liu, Hua Xiong, Aiman Alzetani, Serena J Chee, Ben G Marshall, Sophie V Fletcher, David Hancock, Mark Coldwell, Xianglin Yuan, Christian H Ottensmeier, Julian Downward, Jane E Collins, Rob M Ewing, Luca Richeldi, Paul Skipp, Mark G Jones, Donna E Davies, Yihua Wang
Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis. Cell death and differentiation 26 (5) (2018)
Marc P M Soutar, Liam Kempthorne, Shuichi Miyakawa, Emily Annuario, Daniela Melandri, Jasmine Harley, Gregory A O'Sullivan, Selina Wray, David C Hancock, Mark R Cookson, Julian Downward, Mark Carlton, Hélène Plun-Favreau
AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons. Scientific reports 8 (1) (2018)
Richard Raz, Fabienne Burlina, Mohamed Ismail, Julian Downward, Jiejin Li, Stephen J Smerdon, Martin Quibell, Peter D White, John Offer
HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization. Angewandte Chemie (International ed. in English) 55 (42) (2018)
Heike Miess, Beatrice Dankworth, Arvin M Gouw, Mathias Rosenfeldt, Werner Schmitz, Ming Jiang, Becky Saunders, Michael Howell, Julian Downward, Dean W Felsher, Barrie Peck, Almut Schulze
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene 37 (40) (2018)

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Julian Downward