Enhancing quality and impact of early phase dose-finding clinical trial protocols: SPIRIT Dose-finding Extension (SPIRIT-DEFINE) guidance.
Christina YapJan RekowskiMoreno UrsinoOlga SolovyevaDhrusti PatelMunyaradzi DimairoChristopher J WeirAn-Wen ChanThomas F JakiAdrian P ManderThomas R Jeffry EvansRichard Wilson PeckKathryn S HaywardMelanie Jane CalvertKhadija Rerhou RantellShing LeeAndrew KightleySally HopewellDeborah AshbyElizabeth Garrett-MayerJohn Dudley IsaacsRobert GolubOlga KholmanskikhDawn P RichardsOliver BoixJames MatchamLesley SeymourSusan Percy IvyLynley V MarshallAntoine HommaisRong LiuYoshiya TanakaJordan D BerlinAude EspinasseJohann S de BonoPublished in: BMJ (Clinical research ed.) (2023)