Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies.
Fumiaki ImamuraAmanda M FrettsMatti MarklundAndres V Ardisson KoratWei-Sin YangMaria Anneli LankinenWaqas T QureshiCatherine HelmerTzu-An ChenJyrki K VirtanenKerry L M WongJulie K BassettRachel MurphyNathan L TintleChaoyu Ian YuIngeborg A BrouwerKuo Liong ChienYun-Yu Amelia ChenAlexis C Frazier-WoodLiana C Del GobboLuc DjousseJohanna Marianna GeleijnseGraham G GilesJanette de GoedeVilmundur G GudnasonWilliam S HarrisAllison M HodgeFrank Hunull nullAlbert KoulmanMarkku LaaksoLars LindHung-Ju LinBarbara McKnightKalina RajaobelinaUlf RisérusJennifer G RobinsonCécilia SamieriMackenzie SennDavid S SiscovickSabita S Soedamah-MuthuNona SotoodehniaFrank B HuMichael Y TsaiTomi-Pekka TuomainenMatti UusitupaLynne E WagenknechtNicholas J WarehamJason H Y WuRenata MichaRozenn N LemaitreDariush MozaffarianNita G ForouhiPublished in: PLoS medicine (2020)
Concentrations of fatty acids in the DNL were positively associated with T2D incidence. Our findings support further work to investigate a possible role of DNL and individual fatty acids in the development of T2D.