Potential Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports.
Ana Carolina GonçalvesSofia RodriguesRafael FonsecaLuís Manuel Lopes Rodrigues da SilvaPublished in: Pharmaceuticals (Basel, Switzerland) (2024)
Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental components. Globally, in 2019, 18 million people had RA. RA is characterized by persistent inflammation of the synovial membrane that lines the joints, cartilage loss, and bone erosion. Phenolic molecules are the most prevalent secondary metabolites in plants, with a diverse spectrum of biological actions that benefit functional meals and nutraceuticals. These compounds have received a lot of attention recently because they have antioxidant, anti-inflammatory, immunomodulatory, and anti-rheumatoid activity by modulating tumor necrosis factor, mitogen-activated protein kinase, nuclear factor kappa-light-chain-enhancer of activated B cells, and c-Jun N-terminal kinases, as well as other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, and innovative delivery technologies for the treatment of RA, with a focus on their possible biological activities. Nonetheless, commercialization of polyphenols may be achievable only after confirming their safety profile and completing successful clinical trials.
Keyphrases
- rheumatoid arthritis
- nuclear factor
- disease activity
- ankylosing spondylitis
- clinical trial
- anti inflammatory
- interstitial lung disease
- oxidative stress
- toll like receptor
- rheumatoid arthritis patients
- systemic lupus erythematosus
- ms ms
- emergency department
- signaling pathway
- immune response
- transcription factor
- working memory
- systemic sclerosis
- randomized controlled trial
- body composition
- binding protein
- soft tissue
- postmenopausal women
- risk assessment
- combination therapy
- double blind
- electronic health record