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Effects of Chrysoeriol on Adipogenesis and Lipolysis in 3T3-L1 Adipocytes.

Jinhee SongHana LeeHuijin HeoJun-Soo LeeYounghwa Kim
Published in: Foods (Basel, Switzerland) (2022)
We examined the effect of chrysoeriol on adipogenesis and lipolysis and elucidated the underlying molecular mechanisms. Chrysoeriol inhibited fat deposition in adipocytes. Treatment with chrysoeriol suppressed the expression of peroxisome proliferator-activated receptor γ, fatty acid synthase, fatty acid-binding protein, CCAAT/enhancer-binding proteins (C/EBP) α, C/EBPβ, and sterol regulatory element-binding protein-1. In addition, chrysoeriol significantly elevated the activation of 5'-adenosine monophosphate-activated protein kinase. Moreover, chrysoeriol increased free glycerol and fatty acid levels and promoted lipolysis in adipocytes. Overexpression of adipose triglyceride lipase and hormone-sensitive lipase by chrysoeriol led to increased lipolysis in 3T3-L1 adipocytes. Taken together, chrysoeriol showed anti-adipogenic and lipolytic properties in adipocytes.
Keyphrases
  • adipose tissue
  • binding protein
  • fatty acid
  • insulin resistance
  • high fat diet induced
  • protein kinase
  • transcription factor
  • poor prognosis
  • cell proliferation
  • combination therapy
  • replacement therapy