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ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy.

Angela IannicielloMartha M ZarouKevin M RattiganMary T ScottAmy DawsonKaren M DunnZuzana BrabcovaEric R KalkmanColin NixonAlison M MichieMhairi CoplandDavid VetrieMartin AmblerBarbara SaxtyG Vignir Helgason
Published in: Science translational medicine (2021)
[Figure: see text].
Keyphrases
  • stem cells
  • acute myeloid leukemia
  • smoking cessation
  • induced apoptosis
  • cell therapy
  • oxidative stress
  • endoplasmic reticulum stress
  • bone marrow