G Vignir Helgason (Vignir Helgason)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 24

Top Venues

Nature communications

Leukemia

Science translational medicine

Blood

University of Glasgow Institute of Cancer Sciences

Beatson Institute for Cancer Research (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Glasgow Institute of Cancer Sciences Jun 01 2018

United Kingdom

Senior Lecturer in Cancer Research :: Wolfson Wohl Cancer Research Centre

University of Glasgow Mar 01 2013 - Feb 28 2018

United Kingdom

KKLF/Leadership Fellow :: Wolfson Wohl Cancer Research Centre

University of Glasgow Oct 01 2007 - Feb 28 2013

United Kingdom

Post-doctoal Research Associate :: Paul O'Gorman Leukaemia Research Centre

deCODE Genetics Inc May 01 2000 - Oct 01 2003

Iceland

Research Scientist :: Drug Discovery Division, Functional Genomics/Proteomics

Education History

Beatson Institute for Cancer Research Oct 01 2003 - Oct 31 2007

United Kingdom

PHD

Publications

Martha M Zarou, Kevin M Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen M Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G Vignir Helgason
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing. Nature communications 15 (1) (2024)
Martha M Zarou, Kevin M Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen M Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G Vignir Helgason
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Ahmed Khalaf, Lucie de Beauchamp, Eric R Kalkman, Kevin M Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary T Scott, Karen M Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, G Vignir Helgason
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science translational medicine 16 (751) (2024)
Ahmed Khalaf, Lucie de Beauchamp, Eric R Kalkman, Kevin M Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary T Scott, Karen M Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, G Vignir Helgason
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science translational medicine 16 (751) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Martha M Zarou, Kevin M Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen M Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G Vignir Helgason
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Martha M Zarou, Kevin M Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen M Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G Vignir Helgason
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Kevin M Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M Zarou, Kiron Roy, Ryan Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf, Eric R Kalkman, Mary T Scott, Karen M Dunn, David Sumpton, Alison M Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G Vignir Helgason
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature communications 14 (1) (2023)
Kevin M Rattigan, Martha M Zarou, G Vignir Helgason
Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity. Blood (2023)
Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M Rattigan, Céline Philippe, Vilma Dembitz, Aoife M S Magee, Ryan Asby, Louie N van de Lagemaat, Christopher Mapperley, Sophie C James, Jochen H M Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S Vassiliou, Kamil R Kranc, G Vignir Helgason, Brian James Patrick Huntly, Paolo Gallipoli
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature communications 14 (1) (2023)
Kevin M Rattigan, Martha M Zarou, Zuzana Brabcova, Bodhayan Prasad, Désirée Zerbst, Daniele Sarnello, Eric R Kalkman, Angela Ianniciello, Mary T Scott, Karen Dunn, Engy Shokry, David Sumpton, Mhairi Copland, Saverio Tardito, Johan Vande Voorde, Francis Jay Mussai, Paul Cheng, G Vignir Helgason
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO reports (2023)
Kevin M Rattigan, Martha M Zarou, G Vignir Helgason
Metabolism in stem cell driven leukaemia: parallels between haematopoiesis and immunity. Blood (2023)
Narissa Parry, Caroline Busch, Victoria Aßmann, Jennifer Cassels, Alan Hair, G Vignir Helgason, Helen Wheadon, Mhairi Copland
BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia. Cell death discovery 8 (1) (2022)
Angela Ianniciello, G Vignir Helgason
Targeting ULK1 in cancer stem cells: insight from chronic myeloid leukemia. Autophagy 18 (7) (2022)
Martha M Zarou, Alexei Vazquez, G Vignir Helgason
Folate metabolism: a re-emerging therapeutic target in haematological cancers. Leukemia 35 (6) (2021)
Lucie de Beauchamp, Ekaterini Himonas, G Vignir Helgason
Mitochondrial metabolism as a potential therapeutic target in myeloid leukaemia. Leukemia (2021)
Angela Ianniciello, Martha M Zarou, Kevin M Rattigan, Mary T Scott, Amy Dawson, Karen M Dunn, Zuzana Brabcova, Eric R Kalkman, Colin Nixon, Alison M Michie, Mhairi Copland, David Vetrie, Martin Ambler, Barbara Saxty, G Vignir Helgason
ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science translational medicine 13 (613) (2021)
David Vetrie, G Vignir Helgason, Mhairi Copland
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML. Nature reviews. Cancer 20 (3) (2020)
Pablo Baquero, Amy Dawson, Arunima Mukhopadhyay, Elodie M Kuntz, Rebecca Mitchell, Orianne Olivares, Angela Ianniciello, Mary T Scott, Karen Dunn, Michael C Nicastri, Jeffrey D Winkler, Alison M Michie, Kevin M Ryan, Christina Halsey, Eyal Gottlieb, Erin P Keaney, Leon O Murphy, Ravi K Amaravadi, Tessa L Holyoake, G Vignir Helgason
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia 33 (4) (2018)
Francesca Pellicano, Laura Park, Lisa E M Hopcroft, Mansi M Shah, Lorna Jackson, Mary T Scott, Cassie J Clarke, Amy Sinclair, Sheela A Abraham, Alan Hair, G Vignir Helgason, Mark Aspinall-O'Dea, Ravi Bhatia, Gustavo Leone, Kamil R Kranc, Anthony D Whetton, Tessa L Holyoake
hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood 131 (14) (2018)

G Vignir Helgason.css-eqlu8i{font-size:small;padding-left:4px;} (Vignir Helgason)

Publication Activity (10 Years)

Top Topics

Top Venues

G Vignir Helgason (Vignir Helgason)