Mhairi Copland (M Copland)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 47

Top Venues

Nature communications

British journal of haematology

Leukemia

Current hematologic malignancy reports

University of Glasgow

University of Glasgow (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Glasgow Sep 01 2013

United Kingdom

Professor of Translational Haematology

NHS Greater Glasgow and Clyde Feb 01 2008

United Kingdom

Honorary Consultant in Haematology

University of Glasgow Aug 01 2012 - Aug 30 2013

United Kingdom

Clinical Reader in Translational Haemato-oncology :: Institute of Cancer Sciences

University of Glasgow Feb 01 2008 - Jul 31 2012

United Kingdom

Clinical Senior Lecturer in Translational Haemato-oncology :: Institute of Cancer Sciences

University of Glasgow Oct 01 2006 - Jan 31 2008

United Kingdom

Clinical Lecturer and Honorary Specialist Registrar :: Institute of Cancer Sciences

University of Glasgow Oct 01 2003 - Sep 30 2006

United Kingdom

MRC Clinical Research Training Fellow (administered by University of Glasgow) and Honorary Specialist Registrar,

NHS Greater Glasgow and Clyde Jul 01 2000 - Sep 30 2003

United Kingdom

Specialist Registrar in Haematology :: Department of Haematology

NHS Greater Glasgow and Clyde Jun 15 1999 - Jun 30 2000

United Kingdom

SHO III in Haematology :: Department of Haematology

NHS Grampian Aug 06 1997 - Jun 14 1999

United Kingdom

Senior House Officer Rotation in Medicine :: Dept of Medicine

NHS Grampian Feb 05 1997 - Aug 05 1997

United Kingdom

Pre-Registration House Officer in Medicine

NHS Grampian Aug 06 1996 - Feb 04 1997

United Kingdom

Pre-Registration House Officer in Surgery

Education History

University of Glasgow

United Kingdom

PHD

University of Aberdeen

United Kingdom

BSC :: Department of Medicine and Therapeutics

Publications

Mary T Scott, Wei Liu, Rebecca Mitchell, Cassie J Clarke, Ross Kinstrie, Felix Warren, Hassan Hussain Almasoudi, Thomas Stevens, Karen M Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature communications 15 (1) (2024)
Mary T Scott, Wei Liu, Rebecca Mitchell, Cassie J Clarke, Ross Kinstrie, Felix Warren, Hassan Hussain Almasoudi, Thomas Stevens, Karen M Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature communications 15 (1) (2024)
H F Robertson, D Milojkovic, N Butt, J Byrne, S Claudiani, Mhairi Copland, P Gallipoli, A J Innes, K Knight, A J Mahdi, J Parker, A Virchis, Jane F Apperley
Expectations and outcomes of varying treatment strategies for CML presenting during pregnancy. British journal of haematology (2024)
Mary T Scott, Wei Liu, Rebecca Mitchell, Cassie J Clarke, Ross Kinstrie, Felix Warren, Hassan Hussain Almasoudi, Thomas Stevens, Karen M Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature communications 15 (1) (2024)
Martha M Zarou, Kevin M Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen M Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G Vignir Helgason
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing. Nature communications 15 (1) (2024)
Mary T Scott, Wei Liu, Rebecca Mitchell, Cassie J Clarke, Ross Kinstrie, Felix Warren, Hassan Hussain Almasoudi, Thomas Stevens, Karen M Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature communications 15 (1) (2024)
Mary T Scott, Wei Liu, Rebecca Mitchell, Cassie J Clarke, Ross Kinstrie, Felix Warren, Hassan Hussain Almasoudi, Thomas Stevens, Karen M Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature communications 15 (1) (2024)
Andrew J Innes, Chloe Hayden, Victoria Orovboni, Simone Claudiani, Fiona Fernando, Afzal Khan, David Rees, Jennifer Byrne, Paolo Gallipoli, Sebastian Francis, Mhairi Copland, Gillian A Horne, Manoj Raghavan, Claire Arnold, Angela Collins, Tanya Cranfield, Nicholas Cunningham, Akila Danga, Peter Forsyth, Rebecca Frewin, Paula Garland, Guy Hannah, Daniele Avenoso, Sandra Hassan, Brian James Patrick Huntly, Jissan Husain, Sudhakaran Makkuni, Kate Rothwell, Jamshid Khorashad, Jane F Apperley, Dragana Milojkovic
Impact of BCR::ABL1 single nucleotide variants on asciminib efficacy. Leukemia (2024)
Martha M Zarou, Kevin M Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen M Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G Vignir Helgason
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Ahmed Khalaf, Lucie de Beauchamp, Eric R Kalkman, Kevin M Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary T Scott, Karen M Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, G Vignir Helgason
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science translational medicine 16 (751) (2024)
Ahmed Khalaf, Lucie de Beauchamp, Eric R Kalkman, Kevin M Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary T Scott, Karen M Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, G Vignir Helgason
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science translational medicine 16 (751) (2024)
Mary T Scott, Wei Liu, Rebecca Mitchell, Cassie J Clarke, Ross Kinstrie, Felix Warren, Hassan Hussain Almasoudi, Thomas Stevens, Karen M Dunn, John Pritchard, Mark E Drotar, Alison M Michie, Heather G Jørgensen, Brian Higgins, Mhairi Copland, David Vetrie
Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Martha M Zarou, Kevin M Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen M Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G Vignir Helgason
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Martha M Zarou, Kevin M Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen M Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G Vignir Helgason
Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing. Nature communications 15 (1) (2024)
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen M Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Sin Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature communications 15 (1) (2024)
Kevin M Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M Zarou, Kiron Roy, Ryan Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf, Eric R Kalkman, Mary T Scott, Karen M Dunn, David Sumpton, Alison M Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G Vignir Helgason
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature communications 14 (1) (2023)
Shaun David Patterson, Mhairi Copland
The Bone Marrow Immune Microenvironment in CML: Treatment Responses, Treatment-Free Remission, and Therapeutic Vulnerabilities. Current hematologic malignancy reports 18 (2) (2023)
Shaun David Patterson, Mhairi Copland
The Bone Marrow Immune Microenvironment in CML: Treatment Responses, Treatment-Free Remission, and Therapeutic Vulnerabilities. Current hematologic malignancy reports 18 (2) (2023)
Mhairi Copland, Cono Ariti, Ian F Thomas, Laura Upton, Mia Sydenham, Priyanka Mehta, Shahid Islam, Lars Kjeldsen, Alan K Burnett, Robert K Hills, Nigel H Russell, Mike Dennis, null null
A randomised evaluation of low-dose cytosine arabinoside plus lenalidomide versus single-agent low-dose cytosine arabinoside in older patients with acute myeloid leukaemia: Results from the LI-1 trial. British journal of haematology (2023)
Shaun David Patterson, Mhairi Copland
The Bone Marrow Immune Microenvironment in CML: Treatment Responses, Treatment-Free Remission, and Therapeutic Vulnerabilities. Current hematologic malignancy reports (2023)
Steven Leak, Gillian A Horne, Mhairi Copland
Targeting BCR-ABL1-positive leukaemias: a review article. Cambridge prisms. Precision medicine 1 (2023)
Steven Leak, Gillian A Horne, Mhairi Copland
Targeting BCR-ABL1-positive leukaemias: a review article. Cambridge prisms. Precision medicine 1 (2023)
Shaun David Patterson, Mhairi Copland
The Bone Marrow Immune Microenvironment in CML: Treatment Responses, Treatment-Free Remission, and Therapeutic Vulnerabilities. Current hematologic malignancy reports 18 (2) (2023)
Shaun David Patterson, Mhairi Copland
The Bone Marrow Immune Microenvironment in CML: Treatment Responses, Treatment-Free Remission, and Therapeutic Vulnerabilities. Current hematologic malignancy reports 18 (2) (2023)
Neil Alistair Robertson, Eric Latorre-Crespo, Maria Terradas Terradas, Jorge Lemos-Portela, Alison C Purcell, Benjamin J Livesey, Robert F Hillary, Lee Murphy, Angie Fawkes, Louise MacGillivray, Mhairi Copland, Riccardo E Marioni, Joseph A Marsh, Sarah E Harris, Simon R Cox, Ian J Deary, Linus J Schumacher, Kristina Kirschner, Tamir Chandra
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects. Nature medicine 28 (7) (2022)
Narissa Parry, Caroline Busch, Victoria Aßmann, Jennifer Cassels, Alan Hair, G Vignir Helgason, Helen Wheadon, Mhairi Copland
BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia. Cell death discovery 8 (1) (2022)
Mhairi Copland
Treatment of blast phase chronic myeloid leukaemia: A rare and challenging entity. British journal of haematology 199 (5) (2022)
Mike Dennis, Mhairi Copland, Harpreet Kaur, Jonathan Kell, Emmanouil Nikolousis, Priyanka Mehta, Renuka Palanicawandar, Victoria Potter, Kavita Raj, Ian Thomas, Andrew James Wilson
Management of older patients with frailty and acute myeloid leukaemia: A British Society for Haematology good practice paper. British journal of haematology 199 (2) (2022)
Benjamin Lebecque, Celine Bourgne, Chinmay Munje, Juliette Berger, Thomas Tassin, Pascale Cony-Makhoul, Agnès Guerci-Bresler, Hyacinthe Johnson-Ansah, Wei Liu, Sandrine Saugues, Andrei Tchirkov, David Vetrie, Mhairi Copland, Marc G Berger
The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia. Cancers 14 (19) (2022)
Priyanka Mehta, Nick Telford, Chris Wragg, Richard Dilon, Sylvie D Freeman, Damian Finnegan, Angela Hamblin, Mhairi Copland, Steve Knapper
A British Society for Haematology good practice paper: Recommendations for laboratory testing of UK patients with acute myeloid leukaemia. British journal of haematology (2022)
Francis Jay Mussai, Carmela De Santo, Paul Cheng, Ian F Thomas, Cono Ariti, Laura Upton, Ugo Scarpa, Victoria Stavrou, Mia Sydenham, Alan K Burnett, Steven K Knapper, Priyanka Mehta, Mary Frances Frances McMullin, Mhairi Copland, Nigel H Russell, Mike Dennis
A randomised evaluation of low-dose Ara-C plus pegylated recombinant arginase BCT-100 versus low dose Ara-C in older unfit patients with acute myeloid leukaemia: Results from the LI-1 trial. British journal of haematology (2022)
Eduardo Gómez Castañeda, Lisa E M Hopcroft, Simon Rogers, Chinmay Munje, Joana Bittencourt-Silvestre, Mhairi Copland, David Vetrie, Tessa Holyoake, Heather G Jørgensen
Tyrosine Kinase Inhibitor Independent Gene Expression Signature in CML Offers New Targets for LSPC Eradication Therapy. Cancers 14 (21) (2022)
Anne-Louise Latif, Ashley Newcombe, Sha Li, Kathryn Gilroy, Neil Alistair Robertson, Xue Lei, Helen J S Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-Ichi Sakamaki, Jennifer P Morton, Kevin M Ryan, Stephen W G Tait, Sheela A Abraham, Tessa Holyoake, Brian Higgins, Xu Huang, Karen Blyth, Mhairi Copland, Timothy J T Chevassut, Karen Keeshan, Peter D Adams
BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature communications 12 (1) (2021)
Ya-Ching Hsieh, Kristina Kirschner, Mhairi Copland
Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape. Leukemia 35 (5) (2021)
Wittawat Chantkran, Ya-Ching Hsieh, Daniella Zheleva, Sheelagh Frame, Helen Wheadon, Mhairi Copland
Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell death discovery 7 (1) (2021)
Junjing Qiao, Chen Liang, Dandan Zhao, Le Xuan Truong Nguyen, Fang Chen, Shanshan Suo, Dinh Hoa Hoang, Francesca Pellicano, Ivan Rodriguez Rodriguez, Yasmin Elhajmoussa, Lucy Ghoda, Akihiko Yoshimura, Anthony S Stein, Haris Ali, Paul Koller, Danilo Perrotti, Mhairi Copland, Anjia Han, Bin Amber Zhang, Guido Marcucci
Spred1 deficit promotes treatment resistance and transformation of chronic phase CML. Leukemia (2021)
Wittawat Chantkran, Ya-Ching Hsieh, Daniella Zheleva, Sheelagh Frame, Helen Wheadon, Mhairi Copland
Correction to: Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell death discovery 7 (1) (2021)
Angela Ianniciello, Martha M Zarou, Kevin M Rattigan, Mary T Scott, Amy Dawson, Karen M Dunn, Zuzana Brabcova, Eric R Kalkman, Colin Nixon, Alison M Michie, Mhairi Copland, David Vetrie, Martin Ambler, Barbara Saxty, G Vignir Helgason
ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science translational medicine 13 (613) (2021)
Narissa Parry, Helen Wheadon, Mhairi Copland
The application of BH3 mimetics in myeloid leukemias. Cell death & disease 12 (2) (2021)
Ross Kinstrie, Gillian A Horne, Heather Morrison, David Irvine, Chinmay Munje, Eduardo Gómez Castañeda, Hothri A Moka, Karen M Dunn, Jennifer E Cassels, Narissa Parry, Cassie J Clarke, Mary T Scott, Richard E Clark, Tessa L Holyoake, Helen Wheadon, Mhairi Copland
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia 34 (6) (2020)
Gillian A Horne, J Stobo, C Kelly, A Mukhopadhyay, A L Latif, J Dixon-Hughes, L McMahon, P Cony-Makhoul, Jennifer L Byrne, G Smith, Steffen Koschmieder, T H BrÜmmendorf, P Schafhausen, Paolo Gallipoli, F Thomson, W Cong, R E Clark, D Milojkovic, G V Helgason, L Foroni, F E Nicolini, T L Holyoake, Mhairi Copland
A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease. Leukemia 34 (7) (2020)
David Vetrie, G Vignir Helgason, Mhairi Copland
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML. Nature reviews. Cancer 20 (3) (2020)
Ross Kinstrie, Dimitris Karamitros, Nicolas Goardon, Heather Morrison, Mike Hamblin, Lisa Robinson, Richard E Clark, Mhairi Copland, Paresh Vyas
Heterogeneous leukemia stem cells in myeloid blast phase chronic myeloid leukemia. Blood advances 1 (3) (2016)

Mhairi Copland.css-eqlu8i{font-size:small;padding-left:4px;} (M Copland)

Publication Activity (10 Years)

Top Topics

Top Venues

Mhairi Copland (M Copland)