Identification of Colorectal Cancer Cell Stemness from Single-Cell RNA Sequencing.

Kangyu Lin Saikat Chowdhury Mohammad A Zeineddine Fadl A Zeineddine Nicholas J Hornstein Oscar Eduardo Villarreal Dipen Maheshbhai Maru Cara L Haymaker Jean-Nicholas Vauthey George J Chang Elena Bogatenkova David G Menter Edmund S Kopetz John Paul Shen

Published in: Molecular cancer research : MCR (2024)

This study reveals significant heterogeneity of expression of genes commonly used to identify colorectal CSCs, and identifies a novel stemness signature to identify these cells from scRNA-seq data.

Keyphrases

single cell
rna seq
stem cells
genome wide
high throughput
cancer stem cells
epithelial mesenchymal transition
bioinformatics analysis
poor prognosis
electronic health record
big data
binding protein
gene expression
long non coding rna
artificial intelligence
transcription factor
signaling pathway
deep learning