Identification of Colorectal Cancer Cell Stemness from Single-Cell RNA Sequencing.

Kangyu Lin Saikat Chowdhury Mohammad A Zeineddine Fadl A Zeineddine Nicholas J Hornstein Oscar Eduardo Villarreal Dipen Maheshbhai Maru Cara L Haymaker Jean-Nicholas Vauthey George J Chang Elena Bogatenkova David G Menter Edmund S Kopetz John Paul Shen

Published in: Molecular cancer research : MCR (2024)

This study reveals significant heterogeneity of expression of genes commonly used to identify colorectal CSCs, and identifies a novel stemness signature to identify these cells from scRNA-seq data.

Keyphrases

single cell
rna seq
stem cells
genome wide
high throughput
epithelial mesenchymal transition
cancer stem cells
poor prognosis
bioinformatics analysis
dna methylation
big data
gene expression
machine learning
bone marrow
transcription factor
long non coding rna
cell therapy
mesenchymal stem cells
data analysis