Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype.
Vahid BahrambeigiJaewon J LeeVittorio BranchiKimal I RajapaksheZhichao XuNaishu KuiJason T HenryWang KunBret M StephensSarah DhebatMark W HurdRyan SunPeng YangEytan RuppinWenyi WangEdmund S KopetzAnirban MaitraPaola A GuerreroPublished in: Cancer research (2024)
The development of an approach to interrogate molecular subtypes, cancer-associated pathways, and differentially expressed genes through RNA sequencing of plasma extracellular vesicles lays the foundation for liquid biopsy-based longitudinal monitoring of patient tumor transcriptomes.