Eytan Ruppin

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 84

Top Topics

Small Cell Lung Cancer

Dna Damage Response

Top Venues

Nature communications

Cancer research

Nature metabolism

This page only lists publications with an associated author ORCID identifier.

Publications

Yingying Cao, Tian-Gen Chang, Fiorella Schischlik, Wang Kun, Sanju Sinha, Sridhar Hannenhalli, Peng Jiang, Eytan Ruppin
Inferring characteristics of the tumor-immune microenvironment of HNSCC patients from single-cell transcriptomics of peripheral blood. Cancer research communications (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism (2024)
Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Julia Muenzner, Michael Mulleder, Emma M Campagnolo, Eldad David Shulman, Tian-Gen Chang, Carmela Rubolino, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Silvia Taglietti, Alice Ratti, Chani Stossel, Talia Golan, Francesco Nicassio, Eytan Ruppin, Markus Ralser, Francisca Vazquez, Uri Ben-David, Stefano Santaguida
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage. Nature communications 15 (1) (2024)
Danh-Tai Hoang, Gal Dinstag, Eldad David Shulman, Leandro C Hermida, Doreen S Ben-Zvi, Efrat Elis, Katherine Caley, Stephen-John Sammut, Sanju Sinha, Neelam Sinha, Christopher H Dampier, Chani Stossel, Tejas Patil, Arun Rajan, Wiem Lassoued, Julius Strauss, Shania Bailey, Clint T Allen, Jason Mark Redman, Tuvik Beker, Peng Jiang, Talia Golan, Scott Wilkinson, Adam G Sowalsky, Sharon R Pine, Carlos Caldas, James L Gulley, Kenneth D Aldape, Ranit Aharonov, Eric A Stone, Eytan Ruppin
A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics. Nature cancer (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism 6 (7) (2024)
Ashwin V Kammula, Alejandro A Schäffer, Padma Sheila Rajagopal, Razelle Kurzrock, Eytan Ruppin
Outcome differences by sex in oncology clinical trials. Nature communications 15 (1) (2024)
Sanju Sinha, Rahulsimham Vegesna, Sumit Mukherjee, Ashwin V Kammula, Saugato Rahman Dhruba, Wei Wu, D Lucas Kerr, Nishanth Ulhas Nair, Matthew G Jones, Nir Yosef, Oleg V Stroganov, Ivan Grishagin, Kenneth D Aldape, Collin M Blakely, Peng Jiang, Craig J Thomas, Cyril H Benes, Trever G Bivona, Alejandro A Schäffer, Eytan Ruppin
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors. Nature cancer 5 (6) (2024)
Sanju Sinha, Rahulsimham Vegesna, Sumit Mukherjee, Ashwin V Kammula, Saugato Rahman Dhruba, Wei Wu, D Lucas Kerr, Nishanth Ulhas Nair, Matthew G Jones, Nir Yosef, Oleg V Stroganov, Ivan Grishagin, Kenneth D Aldape, Collin M Blakely, Peng Jiang, Craig J Thomas, Cyril H Benes, Trever G Bivona, Alejandro A Schäffer, Eytan Ruppin
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors. Nature cancer 5 (6) (2024)
Danh-Tai Hoang, Eldad David Shulman, Rust Turakulov, Zied Abdullaev, Omkar Singh, Emma M Campagnolo, H Lalchungnunga, Eric A Stone, Mac Lean P Nasrallah, Eytan Ruppin, Kenneth D Aldape
Prediction of DNA methylation-based tumor types from histopathology in central nervous system tumors with deep learning. Nature medicine (2024)
Tian-Gen Chang, Yingying Cao, Hannah J Sfreddo, Saugato Rahman Dhruba, Se-Hoon Lee, Cristina Valero, Seong-Keun Yoo, Diego Chowell, Luc G T Morris, Eytan Ruppin
LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features. Nature cancer 5 (8) (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism (2024)
Ashwin V Kammula, Alejandro A Schäffer, Padma Sheila Rajagopal, Razelle Kurzrock, Eytan Ruppin
Outcome differences by sex in oncology clinical trials. Nature communications 15 (1) (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez, Sergey Malitsky, Maxim Itkin
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism (2024)
Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Edmund S Kopetz, Anirban Maitra, Paola A Guerrero
Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype. Cancer research (2024)
Tian-Gen Chang, Yingying Cao, Hannah J Sfreddo, Saugato Rahman Dhruba, Se-Hoon Lee, Cristina Valero, Seong-Keun Yoo, Diego Chowell, Luc G T Morris, Eytan Ruppin
LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features. Nature cancer (2024)
Welles Robinson, Joshua K Stone, Fiorella Schischlik, Billel Gasmi, Michael C Kelly, Charlie Seibert, Kimia Dadkhah, Edward Michael Gertz, Joo Sang Lee, Kaiyuan Zhu, Lichun Ma, Xin Wei Wang, S Cenk Sahinalp, Rob Patro, Mark D M Leiserson, Curtis C Harris, Alejandro A Schäffer, Eytan Ruppin
Identification of intracellular bacteria from multiple single-cell RNA-seq platforms using CSI-Microbes. Science advances 10 (27) (2024)
Ashwin V Kammula, Alejandro A Schäffer, Padma Sheila Rajagopal, Razelle Kurzrock, Eytan Ruppin
Outcome differences by sex in oncology clinical trials. Nature communications 15 (1) (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism 6 (7) (2024)
Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Edmund S Kopetz, Anirban Maitra, Paola A Guerrero
Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype. Cancer research (2024)
Danh-Tai Hoang, Gal Dinstag, Eldad David Shulman, Leandro C Hermida, Doreen S Ben-Zvi, Efrat Elis, Katherine Caley, Stephen-John Sammut, Sanju Sinha, Neelam Sinha, Christopher H Dampier, Chani Stossel, Tejas Patil, Arun Rajan, Wiem Lassoued, Julius Strauss, Shania Bailey, Clint T Allen, Jason Mark Redman, Tuvik Beker, Peng Jiang, Talia Golan, Scott Wilkinson, Adam G Sowalsky, Sharon R Pine, Carlos Caldas, James L Gulley, Kenneth D Aldape, Ranit Aharonov, Eric A Stone, Eytan Ruppin
A deep-learning framework to predict cancer treatment response from histopathology images through imputed transcriptomics. Nature cancer (2024)
Nishanth Ulhas Nair, Alejandro A Schäffer, Edward Michael Gertz, Kuoyuan Cheng, Johanna Zerbib, Avinash Das Sahu, Gil Leor, Eldad David Shulman, Kenneth D Aldape, Uri Ben-David, Eytan Ruppin
Chromosome 7 gain compensates for chromosome 10 loss in glioma. Cancer research (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism 6 (7) (2024)
Tian-Gen Chang, Yingying Cao, Hannah J Sfreddo, Saugato Rahman Dhruba, Se-Hoon Lee, Cristina Valero, Seong-Keun Yoo, Diego Chowell, Luc G T Morris, Eytan Ruppin
LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features. Nature cancer 5 (8) (2024)
Sanju Sinha, Rahulsimham Vegesna, Sumit Mukherjee, Ashwin V Kammula, Saugato Rahman Dhruba, Wei Wu, D Lucas Kerr, Nishanth Ulhas Nair, Matthew G Jones, Nir Yosef, Oleg V Stroganov, Ivan Grishagin, Kenneth D Aldape, Collin M Blakely, Peng Jiang, Craig J Thomas, Cyril H Benes, Trever G Bivona, Alejandro A Schäffer, Eytan Ruppin
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors. Nature cancer (2024)
Welles Robinson, Joshua K Stone, Fiorella Schischlik, Billel Gasmi, Michael C Kelly, Charlie Seibert, Kimia Dadkhah, Edward Michael Gertz, Joo Sang Lee, Kaiyuan Zhu, Lichun Ma, Xin Wei Wang, S Cenk Sahinalp, Rob Patro, Mark D M Leiserson, Curtis C Harris, Alejandro A Schäffer, Eytan Ruppin
Identification of intracellular bacteria from multiple single-cell RNA-seq platforms using CSI-Microbes. Science advances 10 (27) (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism (2024)
Sara Zahraeifard, Zhiguang Xiao, Jae Young So, Abdul Ahad, Selina Montoya, Woo Yong Park, Trinadharao Sornapudi, Tiffany Andohkow, Abigail Read, Noemi Kedei, Vishal N Koparde, Howard Hua Yang, Maxwell Ping Lee, Nathan Wong, Maggie Cam, Wang Kun, Eytan Ruppin, Ji Luo, Christine Hollander, Li Yang
Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression. Nature communications 15 (1) (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez
ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism 6 (7) (2024)
Danh-Tai Hoang, Eldad David Shulman, Rust Turakulov, Zied Abdullaev, Omkar Singh, Emma M Campagnolo, H Lalchungnunga, Eric A Stone, Mac Lean P Nasrallah, Eytan Ruppin, Kenneth D Aldape
Prediction of DNA methylation-based tumor types from histopathology in central nervous system tumors with deep learning. Nature medicine 30 (7) (2024)
Sanju Sinha, Rahulsimham Vegesna, Sumit Mukherjee, Ashwin V Kammula, Saugato Rahman Dhruba, Wei Wu, D Lucas Kerr, Nishanth Ulhas Nair, Matthew G Jones, Nir Yosef, Oleg V Stroganov, Ivan Grishagin, Kenneth D Aldape, Collin M Blakely, Peng Jiang, Craig J Thomas, Cyril H Benes, Trever G Bivona, Alejandro A Schäffer, Eytan Ruppin
PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors. Nature cancer (2024)
Tian-Gen Chang, Yingying Cao, Hannah J Sfreddo, Saugato Rahman Dhruba, Se-Hoon Lee, Cristina Valero, Seong-Keun Yoo, Diego Chowell, Luc G T Morris, Eytan Ruppin
LORIS robustly predicts patient outcomes with immune checkpoint blockade therapy using common clinical, pathologic and genomic features. Nature cancer (2024)
Lisha Qiu Jin Lim, Lital N Adler, Emma Hajaj, Leandro R Soria, Rotem Ben-Tov Perry, Naama Darzi, Ruchama Brody, Noa Furth, Michal Lichtenstein, Elizabeta Bab-Dinitz, Ziv Porat, Tevie Melman, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Yael Aylon, Shifra Ben-Dor, Irit Orr, Amir Pri-Or, Rony Seger, Yoav Shaul, Eytan Ruppin, Moshe Oren, Minervo Perez, Jordan Meier, Nicola Brunetti-Pierri, Efrat Shema, Igor Ulitsky, Ayelet Erez
Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nature metabolism (2024)
Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Edmund S Kopetz, Anirban Maitra, Paola A Guerrero
Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype. Cancer research 84 (10) (2024)
Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Eldad David Shulman, Anouk Savir Kadmon, Rachel Slutsky, Tian-Gen Chang, Emma M Campagnolo, Silvia Taglietti, Simone Scorzoni, Sara Gianotti, Sara Martin, Julia Muenzner, Michael Mulleder, Nir Rozenblum, Carmela Rubolino, Tal Ben-Yishay, Kathrin Laue, Yael Cohen-Sharir, Ilaria Vigorito, Francesco Nicassio, Eytan Ruppin, Markus Ralser, Francisca Vazquez, Stefano Santaguida, Uri Ben-David
Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells. Cancer discovery (2024)
Sara Zahraeifard, Zhiguang Xiao, Jae Young So, Abdul Ahad, Selina Montoya, Woo Yong Park, Trinadharao Sornapudi, Tiffany Andohkow, Abigail Read, Noemi Kedei, Vishal N Koparde, Howard Hua Yang, Maxwell Ping Lee, Nathan Wong, Maggie Cam, Wang Kun, Eytan Ruppin, Ji Luo, Christine Hollander, Li Yang
Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression. Nature communications 15 (1) (2024)
Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Edmund S Kopetz, Anirban Maitra, Paola A Guerrero
Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype. Cancer research (2024)
Sara Zahraeifard, Zhiguang Xiao, Jae Young So, Abdul Ahad, Selina Montoya, Woo Yong Park, Trinadharao Sornapudi, Tiffany Andohkow, Abigail Read, Noemi Kedei, Vishal N Koparde, Howard Hua Yang, Maxwell Ping Lee, Nathan Wong, Maggie Cam, Wang Kun, Eytan Ruppin, Ji Luo, Christine Hollander, Li Yang
Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression. Nature communications 15 (1) (2024)
Danh-Tai Hoang, Eldad David Shulman, Rust Turakulov, Zied Abdullaev, Omkar Singh, Emma M Campagnolo, H Lalchungnunga, Eric A Stone, Mac Lean P Nasrallah, Eytan Ruppin, Kenneth D Aldape
Prediction of DNA methylation-based tumor types from histopathology in central nervous system tumors with deep learning. Nature medicine 30 (7) (2024)
Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Edmund S Kopetz, Anirban Maitra, Paola A Guerrero
Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype. Cancer research 84 (10) (2024)
Vahid Bahrambeigi, Jaewon J Lee, Vittorio Branchi, Kimal I Rajapakshe, Zhichao Xu, Naishu Kui, Jason T Henry, Wang Kun, Bret M Stephens, Sarah Dhebat, Mark W Hurd, Ryan Sun, Peng Yang, Eytan Ruppin, Wenyi Wang, Edmund S Kopetz, Anirban Maitra, Paola A Guerrero
Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype. Cancer research 84 (10) (2024)
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K Egan, Ellen Murchie, Michele Ceribelli, Giovanna S Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L Boisvert, Leah J Damon, Kelli M Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J Garnett, Jeffrey A Engelman, Daniel A Haber, Craig J Thomas, Eytan Ruppin, Cyril H Benes
A landscape of response to drug combinations in non-small cell lung cancer. Nature communications 14 (1) (2023)
Ariel Israel, Alejandro A Schäffer, Matitiahu Berkovitch, David J Ozeri, Eugene Merzon, Ilan Green, Avivit Golan Cohen, Eytan Ruppin, Shlomo Vinker, Eli Magen
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Long-Term Risk of Immune-Related diseases. medRxiv : the preprint server for health sciences (2023)
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K Egan, Ellen Murchie, Michele Ceribelli, Giovanna S Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L Boisvert, Leah J Damon, Kelli M Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J Garnett, Jeffrey A Engelman, Daniel A Haber, Craig J Thomas, Eytan Ruppin, Cyril H Benes
A landscape of response to drug combinations in non-small cell lung cancer. Nature communications 14 (1) (2023)
Marzia Scortegagna, Yuanning Du, Linda M Bradley, Wang Kun, Napoleone Ferrara, Eytan Ruppin, Rabi Murad, Ze'ev A Ronai
Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma. Cancer research (2023)
Eytan Ruppin, Danh-Tai Hoang, Gal Dinstag, Leandro Hermida, Doreen S Ben-Zvi, Efrat Elis, Katherine Caley, Stephen-John Sammut, Sanju Sinha, Neelam Sinha, Christopher H Dampier, Chani Stossel, Tejas Patil, Arun Rajan, Wiem Lassoued, Julius Strauss, Shania Bailey, Clint T Allen, Jason Redman, Tuvik Beker, Peng Jiang, Talia Golan, Scott Wilkinson, Adam G Sowalsky, Sharon R Pine, Carlos Caldas, James L Gulley, Kenneth D Aldape, Ranit Aharonov, Eric Stone
Prediction of cancer treatment response from histopathology images through imputed transcriptomics. Research square (2023)
Ariel Israel, Alejandro A Schäffer, Matitiahu Berkovitch, David J Ozeri, Eugene Merzon, Ilan Green, Avivit Golan Cohen, Eytan Ruppin, Shlomo Vinker, Eli Magen
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Long-Term Risk of Immune-Related diseases. medRxiv : the preprint server for health sciences (2023)
Yuelin Liu, Xuan Cindy Li, Farid Rashidi Mehrabadi, Alejandro A Schäffer, Drew Pratt, David R Crawford, Salem Malikic, Erin K Molloy, Vishaka Gopalan, Steve M Mount, Eytan Ruppin, Kenneth D Aldape, S Cenk Sahinalp
Single-cell methylation sequencing data reveal succinct metastatic migration histories and tumor progression models. Genome research (2023)
Ariel Israel, Alejandro A Schäffer, Matitiahu Berkovitch, David J Ozeri, Eugene Merzon, Ilan Green, Avivit Golan Cohen, Eytan Ruppin, Shlomo Vinker, Eli Magen
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Long-Term Risk of Immune-Related diseases. medRxiv : the preprint server for health sciences (2023)
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K Egan, Ellen Murchie, Michele Ceribelli, Giovanna S Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L Boisvert, Leah J Damon, Kelli M Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J Garnett, Jeffrey A Engelman, Daniel A Haber, Craig J Thomas, Eytan Ruppin, Cyril H Benes
A landscape of response to drug combinations in non-small cell lung cancer. Nature communications 14 (1) (2023)
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K Egan, Ellen Murchie, Michele Ceribelli, Giovanna S Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L Boisvert, Leah J Damon, Kelli M Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J Garnett, Jeffrey A Engelman, Daniel A Haber, Craig J Thomas, Eytan Ruppin, Cyril H Benes
A landscape of response to drug combinations in non-small cell lung cancer. Nature communications 14 (1) (2023)
Nishanth Ulhas Nair, Patricia Greninger, Xiaohu Zhang, Adam A Friedman, Arnaud Amzallag, Eliane Cortez, Avinash Das Sahu, Joo Sang Lee, Anahita Dastur, Regina K Egan, Ellen Murchie, Michele Ceribelli, Giovanna S Crowther, Erin Beck, Joseph McClanaghan, Carleen Klump-Thomas, Jessica L Boisvert, Leah J Damon, Kelli M Wilson, Jeffrey Ho, Angela Tam, Crystal McKnight, Sam Michael, Zina Itkin, Mathew J Garnett, Jeffrey A Engelman, Daniel A Haber, Craig J Thomas, Eytan Ruppin, Cyril H Benes
A landscape of response to drug combinations in non-small cell lung cancer. Nature communications 14 (1) (2023)
Yuan Liu, Jingwen Yang, Tianlu Wang, Mei Luo, Yamei Chen, Chengxuan Chen, Ze'ev A Ronai, Yubin Zhou, Eytan Ruppin, Leng Han
Expanding PROTACtable genome universe of E3 ligases. Nature communications 14 (1) (2023)
Hyungsoo Kim, Yongmei Feng, Rabi Murad, Joanna Pozniak, Carl Pelz, Yeqing Chen, Bhavik Dalal, Rosalie C Sears, Eduard Sergienko, Michael Jackson, Eytan Ruppin, Meenhard Herylyn, Curtis C Harris, Jean-Christophe Marine, Victoria Klepsch, Gottfried Baier, Ze'ev A Ronai
Melanoma-intrinsic NR2F6 activity regulates antitumor immunity. Science advances 9 (27) (2023)
Ariel Israel, Alejandro A Schäffer, Matitiahu Berkovitch, David J Ozeri, Eugene Merzon, Ilan Green, Avivit Golan Cohen, Eytan Ruppin, Shlomo Vinker, Eli Magen
Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency and Long-Term Risk of Immune-Related diseases. medRxiv : the preprint server for health sciences (2023)
Rita Perelroizen, Bar Philosof, Noga Budick-Harmelin, Tom Chernobylsky, Ariel Ron, Rotem Katzir, Dor Shimon, Adi Tessler, Orit Adir, Anat Gaoni-Yogev, Tom Meyer, Avivit Krivitsky, Nuphar Shidlovsky, Asaf Madi, Eytan Ruppin, Lior Mayo
Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity. Brain : a journal of neurology 145 (9) (2022)
Kun Wang, Sushant Patkar, Joo Sang Lee, Edward Michael Gertz, Welles Robinson, Fiorella Schischlik, David R Crawford, Alejandro A Schäffer, Eytan Ruppin
Deconvolving Clinically Relevant Cellular Immune Cross-talk from Bulk Gene Expression Using CODEFACS and LIRICS Stratifies Patients with Melanoma to Anti-PD-1 Therapy. Cancer discovery 12 (4) (2022)
Ashish Noronha, Nishanth Belugali Nataraj, Joo Sang Lee, Benny Zhitomirsky, Yaara Oren, Sara Oster, Moshit Lindzen, Saptaparna Mukherjee, Rainer Will, Soma Ghosh, Arturo Simoni-Nieves, Aakanksha Verma, Rishita Chatterjee, Simone Borgoni, Welles Robinson, Sanju Sinha, Alexander Brandis, D Lucas Kerr, Wei Wu, Arunachalam Sekar, Suvendu Giri, Youngmin Chung, Diana Drago-Garcia, Brian P Danysh, Mattia Lauriola, Michelangelo Fiorentino, Andrea Ardizzoni, Moshe Oren, Collin M Blakely, Jideofor Ezike, Stefan Wiemann, Laxmi Parida, Trever G Bivona, Rami I Aqeilan, Joan S Brugge, Aviv Regev, Gad A Getz, Eytan Ruppin, Yosef Yarden
AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer. Cancer discovery 12 (11) (2022)
Neelam Sinha, Sanju Sinha, Kuoyuan Cheng, Sanna Madan, Ayelet Erez, Bríd M Ryan, Alejandro A Schäffer, Kenneth D Aldape, Eytan Ruppin
Using a Recently Approved Tumor Mutational Burden Biomarker to Stratify Patients for Immunotherapy May Introduce a Sex Bias. JCO precision oncology 5 (2022)
Neelam Sinha, Sanju Sinha, Cristina Valero, Alejandro A Schäffer, Kenneth D Aldape, Kevin Litchfield, Timothy A Chan, Luc G T Morris, Eytan Ruppin
Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types. Cancer research 82 (11) (2022)
Ariel Israel, Alejandro A Schäffer, Eugene Merzon, Ilan Green, Eli Magen, Avivit Golan Cohen, Shlomo Vinker, Eytan Ruppin
Predicting COVID-19 severity using major risk factors and received vaccines. medRxiv : the preprint server for health sciences (2022)
Peng Jiang, Sanju Sinha, Kenneth Aldape, Sridhar Hannenhalli, S Cenk Sahinalp, Eytan Ruppin
Big data in basic and translational cancer research. Nature reviews. Cancer 22 (11) (2022)
Nishanth Ulhas Nair, Kuoyuan Cheng, Lamis Naddaf, Elad Sharon, Lipika R Pal, Padma Sheila Rajagopal, Irene Unterman, Kenneth D Aldape, Sridhar Hannenhalli, Chi-Ping Day, Yuval Tabach, Eytan Ruppin
Cross-species identification of cancer resistance-associated genes that may mediate human cancer risk. Science advances 8 (31) (2022)
Georgina D Barnabas, Joo Sang Lee, Tamar Shami, Michal Harel, Lir Beck, Michael Selitrennik, Livnat Jerby-Arnon, Neta Erez, Eytan Ruppin, Tamar Geiger
Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression. Cancer research 81 (6) (2021)
Kuoyuan Cheng, Laura Martin-Sancho, Lipika R Pal, Yuan Pu, Laura Riva, Xin Yin, Sanju Sinha, Nishanth Ulhas Nair, Sumit K Chanda, Eytan Ruppin
Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets. Molecular systems biology 17 (11) (2021)
Ariel Israel, Eugene Merzon, Alejandro A Schäffer, Yotam Shenhar, Ilan Green, Avivit Golan Cohen, Eytan Ruppin, Eli Magen, Shlomo Vinker
Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study. BMJ (Clinical research ed.) 375 (2021)
Mahashweta Basu, Wang Kun, Eytan Ruppin, Sridhar Hannenhalli
Predicting tissue-specific gene expression from whole blood transcriptome. Science advances 7 (14) (2021)
Shelly Kalaora, Adi Nagler, Deborah Nejman, Michal Alon, Chaya Barbolin, Eilon Barnea, Steven L C Ketelaars, Kuoyuan Cheng, Kevin Vervier, Noam Shental, Yuval Bussi, Ron Rotkopf, Ronen Levy, Gil Benedek, Sophie Trabish, Tali Dadosh, Smadar Levin-Zaidman, Leore T Geller, Kun Wang, Polina Greenberg, Gal Yagel, Aviyah Peri, Garold Fuks, Neerupma Bhardwaj, Alexandre Reuben, Leandro C Hermida, Sarah B Johnson, Jessica R Galloway-Peña, William C Shropshire, Chantale Bernatchez, Cara L Haymaker, Reetakshi Arora, Lior Roitman, Raya Eilam, Adina Weinberger, Maya Lotan-Pompan, Michal Lotem, Arie Admon, Yishai Levin, Trevor D Lawley, David J Adams, Mitchell P Levesque, Michal J Besser, Jacob Schachter, Ofra Golani, Eran Segal, Naama Geva-Zatorsky, Eytan Ruppin, Pia Kvistborg, Scott N Peterson, Jennifer A Wargo, Ravid Straussman, Yardena Sameuls
Identification of bacteria-derived HLA-bound peptides in melanoma. Nature 592 (7852) (2021)
Vishaka Gopalan, Arashdeep Singh, Farid Rashidi Mehrabadi, Li Wang, Eytan Ruppin, H Efsun Arda, Sridhar Hannenhalli
A Transcriptionally Distinct Subpopulation of Healthy Acinar Cells Exhibit Features of Pancreatic Progenitors and PDAC. Cancer research 81 (15) (2021)
Ariel Israel, Alejandro A Schäffer, Assi Cicurel, Kuoyuan Cheng, Sanju Sinha, Eyal Schiff, Ilan Feldhamer, Ameer Tal, Gil Lavie, Eytan Ruppin
Identification of drugs associated with reduced severity of COVID-19 - a case-control study in a large population. eLife 10 (2021)
Kuoyuan Cheng, Nishanth Ulhas Nair, Joo Sang Lee, Eytan Ruppin
Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity. Science advances 7 (1) (2021)
Noam Auslander, Daniel M Ramos, Ivette Zelaya, Hiren Karathia, Thomas O Crawford, Alejandro A Schäffer, Charlotte J Sumner, Eytan Ruppin
The GENDULF algorithm: mining transcriptomics to uncover modifier genes for monogenic diseases. Molecular systems biology 16 (12) (2021)
David Liu, Jia-Ren Lin, Emily J Robitschek, Gyulnara G Kasumova, Alex Heyde, Alvin Shi, Adam Kraya, Gao Zhang, Tabea Moll, Dennie T Frederick, Yu-An Chen, Shu Wang, Denis Schapiro, Li-Lun Ho, Kevin Bi, Avinash Sahu, Shaolin Mei, Benchun Miao, Tatyana Sharova, Christopher Alvarez-Breckenridge, Jackson H Stocking, Tommy Kim, Riley Fadden, Donald Lawrence, Mai P Hoang, Daniel P Cahill, Mohsen Malehmir, Martin A Nowak, Priscilla Kaliopi Brastianos, Christine G Lian, Eytan Ruppin, Benjamin Izar, Meenhard Herylyn, Eliezer Van Allen, Katherine L Nathanson, Keith T Flaherty, Ryan J Sullivan, Manolis Kellis, Peter Karl Sorger, Genevieve Marie Boland
Evolution of delayed resistance to immunotherapy in a melanoma responder. Nature medicine 27 (6) (2021)
Ariel Israel, Alejandro A Schäffer, Assi Cicurel, Ilan Feldhamer, Ameer Tal, Kuoyuan Cheng, Sanju Sinha, Eyal Schiff, Gil Lavie, Eytan Ruppin
Identification of drugs associated with reduced severity of COVID-19: A case-control study in a large population. medRxiv : the preprint server for health sciences (2021)
Ariel Israel, Yotam Shenhar, Ilan Green, Eugene Merzon, Avivit Golan-Cohen, Alejandro A Schäffer, Eytan Ruppin, Shlomo Vinker, Eli Magen
Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection. medRxiv : the preprint server for health sciences (2021)
Michal Shreberk-Shaked, Bareket Dassa, Sanju Sinha, Silvia Di Agostino, Ido Azuri, Saptaparna Mukherjee, Yael Aylon, Giovanni Blandino, Eytan Ruppin, Moshe Oren
A Division of Labor between YAP and TAZ in Non-Small Cell Lung Cancer. Cancer research 80 (19) (2020)
Erez Persi, Yuri I Wolf, David Horn, Eytan Ruppin, Francesca Demichelis, Robert A Gatenby, Robert J Gillies, Eugene V Koonin
Mutation-selection balance and compensatory mechanisms in tumour evolution. Nature reviews. Genetics 22 (4) (2020)
Shelly Kalaora, Joo Sang Lee, Eilon Barnea, Ronen Levy, Polina Greenberg, Michal Alon, Gal Yagel, Gitit Bar Eli, Roni Oren, Aviyah Peri, Sushant Patkar, Lital Bitton, Steven A Rosenberg, Michal Lotem, Yishai Levin, Arie Admon, Eytan Ruppin, Yardena Samuels
Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma. Nature communications 11 (1) (2020)
Rosanna Dattilo, Carla Mottini, Emanuela Camera, Alessia Lamolinara, Noam Auslander, Ginevra Doglioni, Michela Muscolini, Wei Tang, Melanie Planque, Cristiana Ercolani, Simonetta Buglioni, Isabella Manni, Daniela Trisciuoglio, Alessandra Boe, Sveva Grande, Anna Maria Luciani, Manuela Iezzi, Gennaro Ciliberto, Stefan Ambs, Ruggero De Maria, Sarah-Maria Fendt, Eytan Ruppin, Luca Cardone
Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem-Like Cells and Reduces Metastases through Effects on Lipid Anabolism. Cancer research 80 (19) (2020)
Nandini Verma, Yaron Vinik, Ashish Saroha, Nishanth Ulhas Nair, Eytan Ruppin, Gordon B Mills, Thomas Karn, Vinay Dubey, Lohit Khera, Harsha Raj, Flavio Maina, Sima Lev
Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis. Science advances 6 (34) (2020)
Sanju Sinha, Kuoyuan Cheng, Alejandro A Schäffer, Kenneth Aldape, Eyal Schiff, Eytan Ruppin
In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression. Molecular systems biology 16 (7) (2020)
Noam Auslander, Joo Sang Lee, Eytan Ruppin
Reply to: 'IMPRES does not reproducibly predict response to immune checkpoint blockade therapy in metastatic melanoma'. Nature medicine 25 (12) (2019)
Avinash Das Sahu, Joo Sang Lee, Zhiyong Wang, Gao Zhang, Ramiro Iglesias-Bartolome, Tian Tian, Zhi Wei, Benchun Miao, Nishanth Ulhas Nair, Olga Ponomarova, Adam A Friedman, Arnaud Amzallag, Tabea Moll, Gyulnara Kasumova, Patricia Greninger, Regina K Egan, Leah J Damon, Dennie T Frederick, Livnat Jerby-Arnon, Allon Wagner, Kuoyuan Cheng, Seung Gu Park, Welles Robinson, Kevin Gardner, Genevieve Boland, Sridhar Hannenhalli, Meenhard Herlyn, Cyril Benes, Keith Flaherty, Ji Luo, J Silvio Gutkind, Eytan Ruppin
Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy. Molecular systems biology 15 (3) (2019)
Gaurav Pathria, David A Scott, Yongmei Feng, Joo Sang Lee, Yu Fujita, Gao Zhang, Avinash D Sahu, Eytan Ruppin, Meenhard Herlyn, Andrei L Osterman, Ze'ev A Ronai
Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival. The EMBO journal 37 (20) (2018)
Noam Auslander, Chelsea E Cunningham, Behzad M Toosi, Emily J McEwen, Keren Yizhak, Frederick S Vizeacoumar, Sreejit Parameswaran, Nir Gonen, Tanya Freywald, Kalpana K Bhanumathy, Andrew Freywald, Franco J Vizeacoumar, Eytan Ruppin
An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer. Molecular systems biology 13 (12) (2017)