Andrew G Leach

Scopus Author ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2022
Publications (10 Years): 23

Top Topics

Capillary Electrophoresis

Crystal Structure

Cystic Fibrosis

Top Venues

Journal of the American Chemical Society

Chemistry (Weinheim an der Bergstrasse, Germany)

Journal of medicinal chemistry

Chemical science

This page only lists publications with an associated author ORCID identifier.

Publications

Dominik Gurvic, Andrew G Leach, Ulrich Zachariae
Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria. Journal of medicinal chemistry 65 (8) (2022)
Andrés García-Domínguez, Andrew G Leach, Guy C Lloyd Jones
In Situ Studies of Arylboronic Acids/Esters and R 3 SiCF 3 Reagents: Kinetics, Speciation, and Dysfunction at the Carbanion-Ate Interface. Accounts of chemical research 55 (9) (2022)
Liam A McLean, Matthew W Ashford, James W B Fyfe, Alexandra M Z Slawin, Andrew G Leach, Allan J B Watson
Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines. Chemistry (Weinheim an der Bergstrasse, Germany) 28 (16) (2022)
Mélanie Uguen, Conghao Gai, Lukas J Sprenger, Hang Liu, Andrew G Leach, Michael J Waring
Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid. RSC advances 11 (48) (2021)
Nicholas P Taylor, Jorge A Gonzalez, Gary S Nichol, Andrés García-Domínguez, Andrew G Leach, Guy C Lloyd Jones
A Lewis Base Nucleofugality Parameter, N F B , and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics. The Journal of organic chemistry 87 (1) (2021)
Hannah L D Hayes, Ran Wei, Michele Assante, Katherine J Geogheghan, Na Jin, Simone Tomasi, Gary Noonan, Andrew G Leach, Guy C Lloyd Jones
Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis. Journal of the American Chemical Society 143 (36) (2021)
Joanna Zarnecka, Iva Lukac, Stephen J Messham, Alhusein Hussin, Francesco Coppola, Steven J Enoch, Alexander G Dossetter, Edward J Griffen, Andrew G Leach
Mapping Ligand-Shape Space for Protein-Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins. Journal of chemical information and modeling 61 (4) (2021)
Nicholas J Cundy, Roseanna K Hare, Tina Tang, Andrew G Leach, Thomas A Jowitt, Omar Qureshi, John Gordon, Nicholas M Barnes, Catherine A Brady, Emma L Raven, Richard S Grainger, Sam Butterworth
Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity. RSC chemical biology 2 (6) (2021)
Jack B Washington, Michele Assante, Chunhui Yan, David McKinney, Vanessa Juba, Andrew G Leach, Sharon E Baillie, Marc Reid
Trialkylammonium salt degradation: implications for methylation and cross-coupling. Chemical science 12 (20) (2021)
Harvey J A Dale, Andrew G Leach, Guy C Lloyd Jones
Heavy-Atom Kinetic Isotope Effects: Primary Interest or Zero Point? Journal of the American Chemical Society (2021)
Andrés García-Domínguez, Thomas H West, Johann J Primozic, Katie M Grant, Craig P Johnston, Grant G Cumming, Andrew G Leach, Guy C Lloyd Jones
Difluorocarbene Generation from TMSCF3: Kinetics and Mechanism of NaI-Mediated and Si-Induced Anionic Chain Reactions. Journal of the American Chemical Society 142 (34) (2020)
Alexandre F Trindade, Emily L Faulkner, Andrew G Leach, Adam Nelson, Stephen P Marsden
Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates. Chemical communications (Cambridge, England) 56 (62) (2020)
Edward J Griffen, Alexander G Dossetter, Andrew G Leach
Chemists: AI Is Here; Unite To Get the Benefits. Journal of medicinal chemistry 63 (16) (2020)
Andrew Ballard, Stefania Narduolo, Hiwa O Ahmed, Nathaniel I Keymer, Nabil Asaad, David A Cosgrove, Niklaas J Buurma, Andrew G Leach
Racemisation in Chemistry and Biology. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (17) (2020)
Eduardo Nieto-Sepulveda, Andrew D Bage, Louise A Evans, Thomas A Hunt, Andrew G Leach, Stephen P Thomas, Guy C Lloyd Jones
Kinetics and Mechanism of the Arase-Hoshi R2BH-Catalyzed Alkyne Hydroboration: Alkenylboronate Generation via B-H/C-B Metathesis. Journal of the American Chemical Society 141 (46) (2019)
Xingjian Li, Daniel T Payne, Badarinath Ampolu, Nicholas Bland, Jane T Brown, Mark J Dutton, Catherine A Fitton, Abigail Gulliver, Lee Hale, Daniel Hamza, Geraint Jones, Rebecca Lane, Andrew G Leach, Louise Male, Elena G Merisor, Michael J Morton, Alex S Quy, Ruth A Roberts, Rosanna Scarll, Timothy Schulz-Utermoehl, Tatjana Stankovic, Brett Stevenson, John S Fossey, Angelo Agathanggelou
Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia. MedChemComm 10 (8) (2019)
Iva Lukac, Hend E Abdelhakim, Richard A Ward, Stephen A St-Gallay, Judith C Madden, Andrew G Leach
Predicting protein-ligand binding affinity and correcting crystal structures with quantum mechanical calculations: lactate dehydrogenase A. Chemical science 10 (7) (2019)
Akina Yoshizawa, Antonio Feula, Louise Male, Andrew G Leach, John S Fossey
Rigid and concave, 2,4-cis-substituted azetidine derivatives: A platform for asymmetric catalysis. Scientific reports 8 (1) (2018)
Craig P Johnston, Thomas H West, Ruth E Dooley, Marc Reid, Ariana B Jones, Edward J King, Andrew G Leach, Guy C Lloyd Jones
Anion-Initiated Trifluoromethylation by TMSCF3: Deconvolution of the Siliconate-Carbanion Dichotomy by Stopped-Flow NMR/IR. Journal of the American Chemical Society 140 (35) (2018)
Sanne J M Verhoork, Claire E Jennings, Neshat Rozatian, Judith Reeks, Jieman Meng, Emily K Corlett, Fazila Bunglawala, Martin E M Noble, Andrew G Leach, Christopher R Coxon
Tuning the Binding Affinity and Selectivity of Perfluoroaryl-Stapled Peptides by Cysteine-Editing. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (1) (2018)
Christian Kramer, Attilla Ting, Hao Zheng, Jérôme Hert, Torsten Schindler, Martin Stahl, Graeme Robb, James J Crawford, Jeff Blaney, Shane Montague, Andrew G Leach, Al G Dossetter, Ed J Griffen
Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA). Journal of medicinal chemistry 61 (8) (2017)
Andrew Ballard, Hiwa O Ahmad, Stefania Narduolo, Lucy Rosa, Nikki Chand, David A Cosgrove, Peter Varkonyi, Nabil Asaad, Simone Tomasi, Niklaas J Buurma, Andrew G Leach
Quantitative Prediction of Rate Constants for Aqueous Racemization To Avoid Pointless Stereoselective Syntheses. Angewandte Chemie (International ed. in English) 57 (4) (2017)
Iva Lukac, Joanna Zarnecka, Edward J Griffen, Alexander G Dossetter, Stephen A St-Gallay, Steven J Enoch, Judith C Madden, Andrew G Leach
Turbocharging Matched Molecular Pair Analysis: Optimizing the Identification and Analysis of Pairs. Journal of chemical information and modeling 57 (10) (2017)