Richard A Ward

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 18

Top Venues

Journal of medicinal chemistry

Journal of chemical information and modeling

ACS medicinal chemistry letters

Biochemistry

AstraZeneca

University of Birmingham School of Chemistry (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

AstraZeneca Oct 01 2002

United Kingdom

Principal Scientist :: Chemistry

Education History

University of Birmingham School of Chemistry Oct 01 1999 - Sep 01 2002

United Kingdom

PHD :: Chemistry

Publications

Nils Pemberton, Nina Compagne, Argyrides Argyrou, Emma Evertsson, Anders Gunnarsson, Jason G Kettle, Jonathan P Orme, Richard A Ward
Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR. ACS medicinal chemistry letters 15 (5) (2024)
Nils Pemberton, Nina Compagne, Argyrides Argyrou, Emma Evertsson, Anders Gunnarsson, Jason G Kettle, Jonathan P Orme, Richard A Ward
Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR. ACS medicinal chemistry letters 15 (5) (2024)
Clare Thomson, Peter Barton, Erin Braybrooke, Nicola Colclough, Zhiqiang Dong, Laura Evans, Nicolas Floc'h, Carine Guérot, David Hargreaves, Puneet Khurana, Songlei Li, Xiuwei Li, Andrew Lister, William McCoull, Lisa McWilliams, Jonathan P Orme, Martin J Packer, Aisha M Swaih, Richard A Ward, Poppy Winlow, Yang Ye
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Journal of medicinal chemistry (2024)
Clare Thomson, Peter Barton, Erin Braybrooke, Nicola Colclough, Zhiqiang Dong, Laura Evans, Nicolas Floc'h, Carine Guérot, David Hargreaves, Puneet Khurana, Songlei Li, Xiuwei Li, Andrew Lister, William McCoull, Lisa McWilliams, Jonathan P Orme, Martin J Packer, Aisha M Swaih, Richard A Ward, Poppy Winlow, Yang Ye
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Journal of medicinal chemistry 67 (11) (2024)
Pasquale A Morese, Nahoum Anthony, Michael S Bodnarchuk, Claire Jennings, Mathew P Martin, Richard A Noble, Nicole Phillips, Huw D Thomas, Lan Z Wang, Andrew Lister, Martin E M Noble, Richard A Ward, Stephen R Wedge, Hannah L Stewart, Michael J Waring
Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release. Journal of medicinal chemistry (2023)
M Raymond V Finlay, Peter Barton, Sue Bickerton, Michal Bista, Nicola Colclough, Darren A E Cross, Laura Evans, Nicolas Floc'h, Clare Gregson, Carine M Guérot, David Hargreaves, Xiaoming Kang, Eva M Lenz, Xu Li, Yi Liu, Olivier Lorthioir, Matthew J Martin, Darren McKerrecher, Claire McWhirter, Daniel O'Neill, Jonathan P Orme, Arash Mosallanejad, Amar Rahi, Paul D Smith, Verity Talbot, Richard A Ward, Gail Wrigley, Marta Wylot, Lin Xue, Tieguang Yao, Yang Ye, Xiliang Zhao
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance. Journal of medicinal chemistry 64 (18) (2021)
João Morado, Paul N Mortenson, J Willem M Nissink, Marcel L Verdonk, Richard A Ward, Jonathan W Essex, Chris-Kriton Skylaris
Generation of Quantum Configurational Ensembles Using Approximate Potentials. Journal of chemical theory and computation 17 (11) (2021)
Ioannis Galdadas, Luca Carlino, Richard A Ward, Samantha J Hughes, Shozeb M Haider, Francesco Luigi Gervasio
Structural basis of the effect of activating mutations on the EGF receptor. eLife 10 (2021)
João Morado, Paul N Mortenson, Marcel L Verdonk, Richard A Ward, Jonathan W Essex, Chris-Kriton Skylaris
ParaMol: A Package for Automatic Parameterization of Molecular Mechanics Force Fields. Journal of chemical information and modeling 61 (4) (2021)
Nicola Colclough, Kan Chen, Peter Johnström, Nicole Strittmatter, Yumei Yan, Gail L Wrigley, Magnus Schou, Richard J A Goodwin, Katarina Varnäs, Sally J Adua, Minghui Zhao, Don X Nguyen, Gareth Maglennon, Peter Barton, James Atkinson, Lin Zhang, Annika Janefeldt, Joanne Wilson, Aaron Smith, Akihiro Takano, Ryosuke Arakawa, Mikhail Kondrashov, Jonas Malmquist, Evgeny Revunov, Ana Vazquez-Romero, Mohammad Mahdi Moein, Albert D Windhorst, Natasha A Karp, M Raymond V Finlay, Richard A Ward, James W T Yates, Paul D Smith, Lars Farde, Zack Cheng, Darren A E Cross
Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (1) (2020)
Kirsten McAulay, Emily A Hoyt, Morgan Thomas, Marianne Schimpl, Michael S Bodnarchuk, Hilary J Lewis, Derek Barratt, Deepa Bhavsar, David M Robinson, Michael J Deery, Derek J Ogg, Gonçalo J L Bernardes, Richard A Ward, Michael J Waring, Jason G Kettle
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. Journal of the American Chemical Society 142 (23) (2020)
Richard A Ward, Stephen Fawell, Nicolas Floc'h, Vikki Flemington, Darren McKerrecher, Paul D Smith
Challenges and Opportunities in Cancer Drug Resistance. Chemical reviews 121 (6) (2020)
Xiang Zhai, Richard A Ward, Peter Doig, Argyrides Argyrou
Insight into the Therapeutic Selectivity of the Irreversible EGFR Tyrosine Kinase Inhibitor Osimertinib through Enzyme Kinetic Studies. Biochemistry 59 (14) (2020)
Richard A Ward, Mark J Anderton, Paul Bethel, Jason Breed, Calum Cook, Emma J Davies, Andrew Dobson, Zhiqiang Dong, Gary Fairley, Paul Farrington, Lyman Feron, Vikki Flemington, Francis D Gibbons, Mark A Graham, Ryan Greenwood, Lyndsey Hanson, Philip Hopcroft, Rachel Howells, Julian Hudson, Michael James, Clifford D Jones, Christopher R Jones, Yongchao Li, Scott Lamont, Richard Lewis, Nicola Lindsay, James McCabe, Thomas McGuire, Philip Rawlins, Karen Roberts, Linda Sandin, Iain Simpson, Steve Swallow, Jia Tang, Gary Tomkinson, Michael Tonge, Zhenhua Wang, Baochang Zhai
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC). Journal of medicinal chemistry 62 (24) (2019)
Iva Lukac, Hend E Abdelhakim, Richard A Ward, Stephen A St-Gallay, Judith C Madden, Andrew G Leach
Predicting protein-ligand binding affinity and correcting crystal structures with quantum mechanical calculations: lactate dehydrogenase A. Chemical science 10 (7) (2019)
Richard Lonsdale, Jonathan Burgess, Nicola Colclough, Nichola L Davies, Eva M Lenz, Alexandra L Orton, Richard A Ward
Expanding the Armory: Predicting and Tuning Covalent Warhead Reactivity. Journal of chemical information and modeling 57 (12) (2017)
Richard A Ward, Paul Bethel, Calum Cook, Emma Davies, Judit E Debreczeni, Gary Fairley, Lyman Feron, Vikki Flemington, Mark A Graham, Ryan Greenwood, Nicola Griffin, Lyndsey Hanson, Philip Hopcroft, Tina D Howard, Julian Hudson, Michael James, Clifford D Jones, Christopher R Jones, Scott Lamont, Richard Lewis, Nicola Lindsay, Karen Roberts, Iain Simpson, Steve St-Gallay, Steve Swallow, Jia Tang, Michael Tonge, Zhenhua Wang, Baochang Zhai
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. Journal of medicinal chemistry 60 (8) (2017)
Jonathan D Wrigley, Gerald Gavory, Iain Simpson, Marian Preston, Helen Plant, Jenna Bradley, Anne U Goeppert, Ewelina Rozycka, Gareth Davies, Jarrod Walsh, Andrea Valentine, Keeva McClelland, Krzysztofa Ewa Odrzywol, Jonathan Renshaw, Joanna Boros, Jonathan Tart, Lindsey Leach, Thorsten Nowak, Richard A Ward, Timothy Harrison, David M Andrews
Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily. ACS chemical biology 12 (12) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Richard A Ward