Jian Jin

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 139

Top Venues

Journal of medicinal chemistry

Journal of the American Chemical Society

Nature

Oncogene

This page only lists publications with an associated author ORCID identifier.

Publications

Julia Velez, Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang-Su Park, Md Kabir, H Ümit Kaniskan, Yan Xiong, Jian Jin
Discovery of the First-in-Class G9a/GLP PROTAC Degrader. Journal of medicinal chemistry (2024)
Zhen Wang, Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu, Li Chen, He Chen, Ling Xie, H Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. Journal of the American Chemical Society (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Zhaoyu Xue, Lihuai Qin, Hongwen Xuan, Kaixiu Luo, Mengying Huang, Ling Xie, Yangzhou Su, Longxia Xu, Josiah Harsh, Brandon Dale, Xiaobing Shi, Xian Chen, Husnu Ümit Kaniskan, Jian Jin, Hong Wen
A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Science advances 10 (35) (2024)
Jing Liu, Xiaoping Hu, Kaixiu Luo, Yan Xiong, Li Chen, Zhen Wang, Hiroyuki Inuzuka, Chao Qian, Xufen Yu, Ling Xie, Adil Muneer, Dingpeng Zhang, Joao A Paulo, Xian Chen, Jian Jin, Wenyi Wei
USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK. Journal of the American Chemical Society (2024)
Zhaoyu Xue, Lihuai Qin, Hongwen Xuan, Kaixiu Luo, Mengying Huang, Ling Xie, Yangzhou Su, Longxia Xu, Josiah Harsh, Brandon Dale, Xiaobing Shi, Xian Chen, Husnu Ümit Kaniskan, Jian Jin, Hong Wen
A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Science advances 10 (35) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature (2024)
Md Kabir, Lihuai Qin, Kaixiu Luo, Yan Xiong, Rebecca A Sidi, Kwang-Su Park, Jian Jin
Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader. Journal of medicinal chemistry 67 (8) (2024)
Sung Eun Wang, Yubao Cheng, Jaechul Lim, Mi-Ae Jang, Emily N Forrest, Yuna Kim, Meaghan Donahue, Sheng-Nan Qiao, Yan Xiong, Jian Jin, Siyuan Steven Wang, Yong-Hui Jiang
Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome. Research square (2024)
Julia Velez, Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang-Su Park, Md Kabir, H Ümit Kaniskan, Yan Xiong, Jian Jin
Discovery of the First-in-Class G9a/GLP PROTAC Degrader. Journal of medicinal chemistry 67 (8) (2024)
Xiaoping Hu, Md Kabir, Yindan Lin, Yan Xiong, Ramon E Parsons, Wei Gu, Jian Jin
Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs). Journal of medicinal chemistry 67 (16) (2024)
Yong-Hui Jiang, Sung Eun Wang, Yubao Cheng, Jaechul Lim, Mi-Ae Jang, Emily Forrest, Yuna Kim, Meaghan Donahue, Sheng-Nan Qiao, Yan Xiong, Jian Jin, Siyuan Steven Wang
Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome. Research square (2024)
Zhen Wang, Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu, Li Chen, He Chen, Ling Xie, H Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. Journal of the American Chemical Society 146 (11) (2024)
Md Kabir, Lihuai Qin, Kaixiu Luo, Yan Xiong, Rebecca A Sidi, Kwang-Su Park, Jian Jin
Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader. Journal of medicinal chemistry (2024)
Md Kabir, Lihuai Qin, Kaixiu Luo, Yan Xiong, Rebecca A Sidi, Kwang-Su Park, Jian Jin
Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader. Journal of medicinal chemistry 67 (8) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature (2024)
Julia Velez, Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang-Su Park, Md Kabir, H Ümit Kaniskan, Yan Xiong, Jian Jin
Discovery of the First-in-Class G9a/GLP PROTAC Degrader. Journal of medicinal chemistry (2024)
Zhen Wang, Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu, Li Chen, He Chen, Ling Xie, H Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. Journal of the American Chemical Society 146 (11) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Zhen Wang, Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu, Li Chen, He Chen, Ling Xie, H Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. Journal of the American Chemical Society 146 (11) (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry 67 (7) (2024)
Zhen Wang, Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu, Li Chen, He Chen, Ling Xie, H Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. Journal of the American Chemical Society 146 (11) (2024)
Joshua Corbin, Xufen Yu, Jian Jin, Ling Cai, Gang Greg Wang
EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth. Oncogene (2024)
Julia Velez, Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang-Su Park, Md Kabir, H Ümit Kaniskan, Yan Xiong, Jian Jin
Discovery of the First-in-Class G9a/GLP PROTAC Degrader. Journal of medicinal chemistry 67 (8) (2024)
Xiaoping Hu, Md Kabir, Yindan Lin, Yan Xiong, Ramon E Parsons, Wei Gu, Jian Jin
Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs). Journal of medicinal chemistry 67 (16) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Zhen Wang, Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu, Li Chen, He Chen, Ling Xie, H Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. Journal of the American Chemical Society 146 (11) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Author Correction: Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry 67 (7) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Julia Velez, Yulin Han, Hyerin Yim, Peiyi Yang, Zhijie Deng, Kwang-Su Park, Md Kabir, H Ümit Kaniskan, Yan Xiong, Jian Jin
Discovery of the First-in-Class G9a/GLP PROTAC Degrader. Journal of medicinal chemistry 67 (8) (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry (2024)
Amanda L Graboski, Joshua B Simpson, Samuel J Pellock, Naimee Mehta, Benjamin C Creekmore, Yamuna Ariyarathna, Aadra P Bhatt, Parth B Jariwala, Josh J Sekela, Mark E Kowalewski, Natalie K Barker, Angie L Mordant, Valentina B Borlandelli, Herman S Overkleeft, Laura E Herring, Jian Jin, Lindsey I James, Matthew R Redinbo
Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity. RSC chemical biology 5 (9) (2024)
Joshua Corbin, Xufen Yu, Jian Jin, Ling Cai, Gang Greg Wang
EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth. Oncogene 43 (36) (2024)
Sung Eun Wang, Yubao Cheng, Jaechul Lim, Mi-Ae Jang, Emily N Forrest, Yuna Kim, Meaghan Donahue, Sheng-Nan Qiao, Yan Xiong, Jian Jin, Siyuan Steven Wang, Yong-Hui Jiang
Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome. Research square (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry 67 (7) (2024)
Zhen Wang, Dingpeng Zhang, Xing Qiu, Hiroyuki Inuzuka, Yan Xiong, Jing Liu, Li Chen, He Chen, Ling Xie, H Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Structurally Specific Z-DNA Proteolysis Targeting Chimera Enables Targeted Degradation of Adenosine Deaminase Acting on RNA 1. Journal of the American Chemical Society 146 (11) (2024)
Yan Xiong, Holger Greschik, Catrine Johansson, Ludwig Seifert, Vicki Gamble, Kwang-Su Park, Vincent Fagan, Fengling Li, Irene Chau, Masoud Vedadi, Cheryl H Arrowsmith, Paul Brennan, Oleg Fedorov, Manfred Jung, Gillian Farnie, Jing Liu, Udo Oppermann, Roland Schüle, Jian Jin
Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor. Journal of medicinal chemistry 67 (7) (2024)
Bridget K Marcellino, Xiaobao Yang, H Ümit Kaniskan, Claudia Brady, He Chen, Karie Chen, Xing Qiu, Cara Clementelli, Lauren Herschbein, Zhijun Li, Sebastian Elghaity-Beckley, Joann Arandela, Brianna Kelly, Ronald Hoffman, Jing Liu, Yue Xiong, Jian Jin, Alan H Shih
Correction: An MDM2 degrader for treatment of acute leukemias. Leukemia (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023)
Vladimir M Pogorelov, Michael L Martini, Jian Jin, William C Wetsel, Marc G Caron
Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists. Biomolecules 13 (11) (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023)
Zhen Wang, Jing Liu, He Chen, Xing Qiu, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society 145 (19) (2023)
Zhen Wang, Jing Liu, He Chen, Xing Qiu, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society 145 (19) (2023)
Rachel Litke, Kun-Hyung Roh, YoneJung Yoon, Sindhu Vangeti, Irene Ramos, Husnu Kaniskan, Jian Jin, Christopher Paul Kellner, Charles Mobbs
Novel compound inhibits glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheimer's, Huntington's, and stroke: Aging as a consequence of glycolysis. bioRxiv : the preprint server for biology (2023)
Isha Singh, Fengling Li, Elissa A Fink, Irene Chau, Alice Shi Ming Li, Annía Rodriguez-Hernández, Isabella Glenn, Francisco J Zapatero-Belinchón, M Luis Rodriguez, Kanchan Devkota, Zhijie Deng, Kris White, Xiaobo Wan, Nataliya A Tolmachova, Yurii S Moroz, Husnu Ümit Kaniskan, Melanie Ott, Adolfo García-Sastre, Jian Jin, Danica Galonić Fujimori, John J Irwin, Masoud Vedadi, Brian K Shoichet
Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase. Journal of medicinal chemistry (2023)
Zhen Wang, Jing Liu, Xing Qiu, Dingpeng Zhang, Hiroyuki Inuzuka, Li Chen, He Chen, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2. Journal of the American Chemical Society (2023)
Zhen Wang, Jing Liu, He Chen, Xing Qiu, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society 145 (19) (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene 42 (13) (2023)
Xufen Yu, Dong-Xu Li, Jithesh Kottur, Huen Suk Kim, Laura E Herring, Yao Yu, Ling Xie, Xiaoping Hu, Xian Chen, Ling Cai, Jing Liu, Aneel K Aggarwal, Gang Greg Wang, Jian Jin
Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. Journal of medicinal chemistry (2023)
Fabin Dang, Lei Bai, Jiazhen Dong, Xiaoping Hu, Jingchao Wang, Joao A Paulo, Yan Xiong, Xiaowei Liang, Yishuang Sun, Yuncai Chen, Ming Guo, Xin Wang, Zhixiang Huang, Hiroyuki Inuzuka, Li Chen, Chen Chu, Jianping Liu, Tao Zhang, Abdol-Hossein Rezaeian, Jing Liu, Husnu Ümit Kaniskan, Bo Zhong, Jinfang Zhang, Michael Letko, Jian Jin, Ke Lan, Wenyi Wei
USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Science translational medicine 15 (725) (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023)
Zhen Wang, Jing Liu, He Chen, Xing Qiu, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society (2023)
Md Kabir, Ning Sun, Xiaoping Hu, Tiphaine C Martin, Jingjie Yi, Yue Zhong, Yan Xiong, Husnu Ümit Kaniskan, Wei Gu, Ramon Parsons, Jian Jin
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. Journal of the American Chemical Society (2023)
Alex Rialdi, Mary Duffy, Alex P Scopton, Frank Fonseca, Julia Nanyi Zhao, Megan Schwarz, Pedro Molina-Sanchez, Slim Mzoughi, Elisa Arceci, Jordi Abril-Fornaguera, Austin Meadows, Marina Ruiz de Galarreta, Denis Torre, Kyna Reyes, Yan Ting Lim, Felix Rosemann, Zaigham M Khan, Kevin Mohammed, Xuedi Wang, Xufen Yu, Manikandan Lakshmanan, Ravisankar Rajarethinam, Soo Yong Tan, Jian Jin, Augusto Villanueva, Eleftherios Michailidis, Ype P De Jong, Charles M Rice, Ivan Marazzi, Dan Hasson, Josep M Llovet, Radoslaw Mikolaj Sobota, Amaia Lujambio, Ernesto Guccione, Arvin C Dar
WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. Nature cancer (2023)
Kwang-Su Park, Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong, Arum Kim, Gang Greg Wang, Husnu Ümit Kaniskan, Jian Jin
Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023)
Leslie Salas-Estrada, Davide Provasi, Xing Qiu, Husnu Ümit Kaniskan, Xi-Ping Huang, Jeffrey F DiBerto, João Marcelo Lamim Ribeiro, Jian Jin, Bryan L Roth, Marta Filizola
De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework. Journal of chemical information and modeling (2023)
Jingjie Yi, Huan Li, Bo Chu, Ning Kon, Xiaoping Hu, Jianping Hu, Yan Xiong, H Umit Kaniskan, Jian Jin, Wei Gu
Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1. Cell death and differentiation (2023)
Xian Chen, Ling Xie, Ryan N Sheehy, Yan Xiong, Adil Muneer, John A Wrobel, Kwang-Su Park, Jing Liu, Julia Velez, Yanjia Luo, Ya-Dong Li, Luis Quintanilla, Yongyi Li, Chongchong Xu, Zhexing Wen, Juan Song, Jian Jin, Mohanish Deshmukh
Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication. Research square (2023)
Md Kabir, Xufen Yu, Husnu Ümit Kaniskan, Jian Jin
Chemically induced degradation of epigenetic targets. Chemical Society reviews (2023)
Qin Wu, David Y Nie, Wail Ba-Alawi, YiShuai Ji, ZiWen Zhang, Jennifer Cruickshank, Jillian Haight, Felipe E Ciamponi, Jocelyn Chen, Shili Duan, Yudao Shen, Jing Liu, Sajid A Marhon, Parinaz Mehdipour, Magdalena M Szewczyk, Nergiz Dogan-Artun, WenJun Chen, Lan Xin Zhang, Genevieve Deblois, Panagiotis Prinos, Katlin B Massirer, Dalia Barsyte-Lovejoy, Jian Jin, Daniel D De Carvalho, Benjamin Haibe-Kains, XiaoJia Wang, David W Cescon, Mathieu Lupien, Cheryl H Arrowsmith
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nature chemical biology 18 (8) (2022)
Davide Esposito, Ila Pant, Yao Shen, Rui F Qiao, Xiaobao Yang, Yiyang Bai, Jian Jin, Poulikos I Poulikakos, Stuart A Aaronson
ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation. Nature communications 13 (1) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Shicheng Zhang, He Chen, Chengwei Zhang, Ying Yang, Petr Popov, Jing Liu, Brian E Krumm, Can Cao, Kuglae Kim, Yan Xiong, Vsevolod Katritch, Brian K Shoichet, Jian Jin, Jonathan F Fay, Bryan L Roth
Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nature structural & molecular biology 29 (7) (2022)
Jun Wang, Xufen Yu, Weida Gong, Xijuan Liu, Kwang-Su Park, Anqi Ma, Yi-Hsuan Tsai, Yudao Shen, Takashi Onikubo, Wen-Chieh Pi, David F Allison, Jing Liu, Wei-Yi Chen, Ling Cai, Robert G Roeder, Jian Jin, Gang Greg Wang
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. Nature cell biology 24 (3) (2022)
Xufen Yu, Jia Xu, Kaitlyn M Cahuzac, Ling Xie, Yudao Shen, Xian Chen, Jing Liu, Ramon E Parsons, Jian Jin
Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells. Journal of medicinal chemistry 65 (20) (2022)
Alison N Kurimchak, Carlos Herrera-Montávez, Sara Montserrat-Sangrà, Daniela Araiza-Olivera, Jianping Hu, Ryan Neumann-Domer, Mathew Kuruvilla, Alfonso Bellacosa, Joseph R Testa, Jian Jin, James S Duncan
The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells. Science signaling 15 (749) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Brandon Dale, Chris Anderson, Kwang-Su Park, Husnu Ümit Kaniskan, Anqi Ma, Yudao Shen, Chengwei Zhang, Ling Xie, Xian Chen, Xufen Yu, Jian Jin
Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2. ACS pharmacology & translational science 5 (7) (2022)
Kwang-Su Park, Yan Xiong, Hyerin Yim, Julia Velez, Nicolas Babault, Prashasti Kumar, Jing Liu, Jian Jin
Discovery of the First-in-Class G9a/GLP Covalent Inhibitors. Journal of medicinal chemistry 65 (15) (2022)
Fanye Meng, Chenxi Xu, Kwang-Su Park, Husnu Ümit Kaniskan, Gang Greg Wang, Jian Jin
Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos. Journal of medicinal chemistry 65 (15) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Anna Montanaro, Samuel Kitara, Elisa Cerretani, Matteo Marchesini, Chiara Rompietti, Luca Pagliaro, Andrea Gherli, Angela Su, Maria Laura Minchillo, Mariafrancesca Caputi, Rodanthi Fioretzaki, Bruno Lorusso, Linda Ross, Gabriela Alexe, Elena Masselli, Marina Marozzi, Federica Maria Angela Rizzi, Roberta La Starza, Cristina Mecucci, Yan Xiong, Jian Jin, Angela Falco, Birgit Knoechel, Franco Aversa, Olivia Candini, Federico Quaini, Paolo Sportoletti, Kimberly Stegmaier, Giovanni Roti
Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia. Cell death & disease 13 (6) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Bridget K Marcellino, Xiaobao Yang, H Ümit Kaniskan, Claudia Brady, He Chen, Karie Chen, Xing Qiu, Cara Clementelli, Lauren Herschbein, Zhijun Li, Sebastian Elghaity-Beckley, Joann Arandela, Brianna Kelly, Ronald Hoffman, Jing Liu, Yue Xiong, Jian Jin, Alan H Shih
An MDM2 degrader for treatment of acute leukemias. Leukemia (2022)
Xufen Yu, Meng Cheng, Kaylene Lu, Yudao Shen, Yue Zhong, Jing Liu, Yue Xiong, Jian Jin
Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras. Journal of medicinal chemistry 65 (12) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Jing Liu, Xufen Yu, He Chen, Husnu Ümit Kaniskan, Ling Xie, Xian Chen, Jian Jin, Wenyi Wei
TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors. Journal of the American Chemical Society 144 (28) (2022)
Dongxu Li, Xufen Yu, Jithesh Kottur, Weida Gong, Zhao Zhang, Aaron J Storey, Yi-Hsuan Tsai, Hidetaka Uryu, Yudao Shen, Stephanie D Byrum, Rick D Edmondson, Samuel G Mackintosh, Ling Cai, Zhijie Liu, Aneel K Aggarwal, Alan J Tackett, Jing Liu, Jian Jin, Gang Greg Wang
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene 41 (24) (2022)
Xufen Yu, Jia Xu, Yudao Shen, Kaitlyn M Cahuzac, Kwang-Su Park, Brandon Dale, Jing Liu, Ramon E Parsons, Jian Jin
Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies. Journal of medicinal chemistry 65 (4) (2022)
Zhihong Ren, Arum Kim, Yu-Ting Huang, Wen-Chieh Pi, Weida Gong, Xufen Yu, Jun Qi, Jian Jin, Ling Cai, Robert G Roeder, Wei-Yi Chen, Gang Greg Wang
A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Yan Xiong, Yue Zhong, Hyerin Yim, Xiaobao Yang, Kwang-Su Park, Ling Xie, Poulikos I Poulikakos, Xiaoran Han, Yue Xiong, Xian Chen, Jing Liu, Jian Jin
Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets. Journal of the American Chemical Society (2022)
Wesley L Cai, Jocelyn Fang-Yi Chen, Huacui Chen, Emily Wingrove, Sarah J Kurley, Lok Hei Chan, Meiling Zhang, Anna Arnal-Estape, Minghui Zhao, Amer Balabaki, Wenxue Li, Xufen Yu, Ethan D Krop, Yali Dou, Yansheng Liu, Jian Jin, Thomas F Westbrook, Don X Nguyen, Qin Yan
Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation. eLife 11 (2022)
Jing Liu, He Chen, Husnu Ümit Kaniskan, Ling Xie, Xian Chen, Jian Jin, Wenyi Wei
TF-PROTACs Enable Targeted Degradation of Transcription Factors. Journal of the American Chemical Society 143 (23) (2021)
Xin Yang, Xingwu Wang, Zhiming Li, Shoufu Duan, Huan Li, Jian Jin, Zhiguo Zhang, Wei Gu
An unexpected role for Dicer as a reader of the unacetylated DNA binding domain of p53 in transcriptional regulation. Science advances 7 (44) (2021)
Shashidhar S Jatiani, Stephanie Christie, Violetta V Leshchenko, Rinku Jain, Abhijeet Kapoor, Paola Bisignano, Clement Lee, H Ümit Kaniskan, Donna Edwards, Fanye Meng, Alessandro Laganà, Youssef Youssef, Adrian Wiestner, Lapo Alinari, Jian Jin, Marta Filizola, Aneel K Aggarwal, Samir Parekh
SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (16) (2021)
Kamakoti P Bhat, H Ümit Kaniskan, Jian Jin, Or Gozani
Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nature reviews. Drug discovery 20 (4) (2021)
Xufen Yu, Dongxu Li, Jithesh Kottur, Yudao Shen, Huen Suk Kim, Kwang-Su Park, Yi-Hsuan Tsai, Weida Gong, Jun Wang, Kyogo Suzuki, Joel S Parker, Laura E Herring, Husnu Ümit Kaniskan, Ling Cai, Rinku Jain, Jing Liu, Aneel K Aggarwal, Gang Greg Wang, Jian Jin
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Science translational medicine 13 (613) (2021)
Jing Liu, He Chen, Yi Liu, Yudao Shen, Fanye Meng, Husnu Ümit Kaniskan, Jian Jin, Wenyi Wei
Cancer Selective Target Degradation by Folate-Caged PROTACs. Journal of the American Chemical Society 143 (19) (2021)
Jia Xu, Xufen Yu, Tiphaine C Martin, Ankita Bansal, Kakit Cheung, Abigail Lubin, Elias Stratikopoulos, Kaitlyn M Cahuzac, Li Wang, Ling Xie, Royce Zhou, Yudao Shen, Xuewei Wu, Shen Yao, Ruifang Qiao, Poulikos I Poulikakos, Xian Chen, Jing Liu, Jian Jin, Ramon Parsons
AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. Cancer discovery (2021)
He Chen, Jing Liu, Husnu Ümit Kaniskan, Wenyi Wei, Jian Jin
Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras. Journal of medicinal chemistry 64 (16) (2021)
Michael L Martini, Caroline Ray, Xufen Yu, Jing Liu, Vladimir M Pogorelov, William C Wetsel, Xi-Ping Huang, John D McCorvy, Marc G Caron, Jian Jin
Addition to "Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity". ACS chemical neuroscience 12 (8) (2021)
Xufen Yu, Jia Xu, Ling Xie, Li Wang, Yudao Shen, Kaitlyn M Cahuzac, Xian Chen, Jing Liu, Ramon E Parsons, Jian Jin
Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders. Journal of medicinal chemistry (2021)
Brandon Dale, Meng Cheng, Kwang-Su Park, Husnu Ümit Kaniskan, Yue Xiong, Jian Jin
Advancing targeted protein degradation for cancer therapy. Nature reviews. Cancer 21 (10) (2021)
Can Cao, Hye Jin Kang, Isha Singh, He Chen, Chengwei Zhang, Wenlei Ye, Byron W Hayes, Jing Liu, Ryan H Gumpper, Brian J Bender, Samuel T Slocum, Brian E Krumm, Katherine Lansu, John D McCorvy, Wesley K Kroeze, Justin G English, Jeffrey F DiBerto, Reid H J Olsen, Xi-Ping Huang, Shicheng Zhang, Yong-Feng Liu, Kuglae Kim, Joel Karpiak, Lily Yeh Jan, Soman N Abraham, Jian Jin, Brian K Shoichet, Jonathan F Fay, Bryan L Roth
Structure, function and pharmacology of human itch GPCRs. Nature 600 (7887) (2021)
Patrick Nylund, Alba Atienza Párraga, Jakob Haglöf, Elke De Bruyne, Eline Menu, Berta Garrido-Zabala, Anqi Ma, Jian Jin, Fredrik Öberg, Karin Vanderkerken, Antonia Kalushkova, Helena Jernberg-Wiklund
A distinct metabolic response characterizes sensitivity to EZH2 inhibition in multiple myeloma. Cell death & disease 12 (2) (2021)

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Jian Jin