Avner Schlessinger

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 38

Top Topics

Molecular Dynamics Simulations

Attention Deficit Hyperactivity Disorder

Machine Learning

Top Venues

Nature genetics

PLoS computational biology

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Keino Hutchinson, Avner Schlessinger
Comprehensive Characterization of LAT1 Cholesterol-Binding Sites. Journal of chemical theory and computation 20 (8) (2024)
Noah B Herrington, Yan Chak Li, David Stein, Gaurav Pandey, Avner Schlessinger
A comprehensive exploration of the druggable conformational space of protein kinases using AI-predicted structures. PLoS computational biology 20 (7) (2024)
Keino Hutchinson, Avner Schlessinger
Comprehensive Characterization of LAT1 Cholesterol-Binding Sites. Journal of chemical theory and computation (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Noah B Herrington, Yan Chak Li, David Stein, Gaurav Pandey, Avner Schlessinger
A comprehensive exploration of the druggable conformational space of protein kinases using AI-predicted structures. PLoS computational biology 20 (7) (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Noah B Herrington, Yan Chak Li, David Stein, Gaurav Pandey, Avner Schlessinger
A comprehensive exploration of the druggable conformational space of protein kinases using AI-predicted structures. PLoS computational biology 20 (7) (2024)
Yang Dong, Jiali Wang, Rachel-Ann Garibsingh, Keino Hutchinson, Yueyue Shi, Gilad Eisenberg, Xiaozhen Yu, Avner Schlessinger, Christof T Grewer
Conserved allosteric inhibition mechanism in SLC1 transporters. eLife 12 (2023)
Yang Dong, Jiali Wang, Rachel-Ann Garibsingh, Keino Hutchinson, Yueyue Shi, Gilad Eisenberg, Xiaozhen Yu, Avner Schlessinger, Christof T Grewer
Conserved allosteric inhibition mechanism in SLC1 transporters. eLife 12 (2023)
Yang Dong, Jiali Wang, Rachel-Ann Garibsingh, Keino Hutchinson, Yueyue Shi, Gilad Eisenberg, Xiaozhen Yu, Avner Schlessinger, Christof T Grewer
Conserved allosteric inhibition mechanism in SLC1 transporters. eLife 12 (2023)
Michael J Capper, Shifan Yang, Alexander C Stone, Sezen Vatansever, Gregory Zilberg, Yamuna Kalyani Mathiharan, Raul Habib, Keino Hutchinson, Yihan Zhao, Avner Schlessinger, Mihaly Mezei, Roman Osman, Bin Zhang, Daniel Wacker
Substrate binding and inhibition of the anion exchanger 1 transporter. Nature structural & molecular biology (2023)
Nicole Zatorski, Yifei Sun, Abdulkadir Elmas, Christian Dallago, Timothy Karl, David Stein, Burkhard Rost, Kuan-Lin Huang, Martin Walsh, Avner Schlessinger
Structural Analysis of Genomic and Proteomic Signatures Reveal Dynamic Expression of Intrinsically Disordered Regions in Breast Cancer and Tissue. bioRxiv : the preprint server for biology (2023)
Noah B Herrington, David Stein, Yan Chak Li, Gaurav Pandey, Avner Schlessinger
Exploring the Druggable Conformational Space of Protein Kinases Using AI-Generated Structures. bioRxiv : the preprint server for biology (2023)
Yang Dong, Jiali Wang, Rachel-Ann Garibsingh, Keino Hutchinson, Yueyue Shi, Gilad Eisenberg, Xiaozhen Yu, Avner Schlessinger, Christof T Grewer
Conserved allosteric inhibition mechanism in SLC1 transporters. eLife 12 (2023)
Nicole Zatorski, Yifei Sun, Abdulkadir Elmas, Christian Dallago, Timothy Karl, David Stein, Burkhard Rost, Kuan-Lin Huang, Martin Walsh, Avner Schlessinger
Structural Analysis of Genomic and Proteomic Signatures Reveal Dynamic Expression of Intrinsically Disordered Regions in Breast Cancer and Tissue. bioRxiv : the preprint server for biology (2023)
Avner Schlessinger, Massimiliano Bonomi
Exploring the conformational diversity of proteins. eLife 11 (2022)
Nicole Zatorski, David Stein, Rayees Rahman, Ravi Iyengar, Avner Schlessinger
Structural signatures: a web server for exploring a database of and generating protein structural features from human cell lines and tissues. Database : the journal of biological databases and curation 2022 (2022)
Megan L Koleske, Gregory McInnes, Julia E H Brown, Neil Thomas, Keino Hutchinson, Marcus Y Chin, Antoine Koehl, Michelle R Arkin, Avner Schlessinger, Renata C Gallagher, Yun S Song, Russ B Altman, Kathleen M Giacomini
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency. Proceedings of the National Academy of Sciences of the United States of America 119 (46) (2022)
Anna Cichońska, Balaguru Ravikumar, Robert J Allaway, Fangping Wan, Sungjoon Park, Oleksandr Isaev, Shuya Li, Michael Mason, Andrew Lamb, Ziaurrehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen J Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, Jaewoo Kang, Carrow I Wells, Timothy M Willson, null null, Tudor I Oprea, Avner Schlessinger, David Harold Drewry, Gustavo Stolovitzky, Krister Wennerberg, Justin Guinney, Tero Aittokallio
Crowdsourced mapping of unexplored target space of kinase inhibitors. Nature communications 12 (1) (2021)
Zhaoping Xiong, Minji Jeon, Robert J Allaway, Jaewoo Kang, Donghyeon Park, Jinhyuk Lee, Hwisang Jeon, Miyoung Ko, Hualiang Jiang, Mingyue Zheng, Aik Choon Tan, Xindi Guo, null null, Kristen K Dang, Alex Tropsha, Chana Hecht, Tirtha K Das, Heather A Carlson, Ruben Abagyan, Justin Guinney, Avner Schlessinger, Ross Cagan
Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge. PLoS computational biology 17 (9) (2021)
Ryan H B Smith, Zaigham M Khan, Peter Man-Un Ung, Alex P Scopton, Lisa Silber, Seshat M Mack, Alexander M Real, Avner Schlessinger, Arvin C Dar
Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα. Biochemistry 60 (4) (2021)
Rachel-Ann A Garibsingh, Elias Ndaru, Alisa A Garaeva, Yueyue Shi, Laura Zielewicz, Paul Zakrepine, Massimiliano Bonomi, Dirk Jan Slotboom, Cristina Paulino, Christof T Grewer, Avner Schlessinger
Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proceedings of the National Academy of Sciences of the United States of America 118 (37) (2021)
Rayees Rahman, Nicole Zatorski, Jens Hansen, Yuguang Xiong, Johan G C van Hasselt, Eric A Sobie, Marc R Birtwistle, Evren U Azeloglu, Ravi Iyengar, Avner Schlessinger
Protein structure-based gene expression signatures. Proceedings of the National Academy of Sciences of the United States of America 118 (19) (2021)
Cheng-Chia Tang, Christian D Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J Brooks, Mary L Bouxsein, Janaina da Silva Martins, Jinhua Wang, Nathanael S Gray, Barbara Misof, Paul Roschger, Stephane Blouin, Klaus Klaushofer, Annegreet Velduis-Vlug, Yosta Vegting, Clifford J Rosen, Daniel O'Connell, Thomas B Sundberg, Ramnik J Xavier, Peter Ung, Avner Schlessinger, Henry M Kronenberg, Rebecca Berdeaux, Marc Foretz, Marc N Wein
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption. eLife 10 (2021)
Christos Adamopoulos, Tamer A Ahmed, Maxwell R Tucker, Peter M U Ung, Min Xiao, Zoi Karoulia, Angelo Amabile, Xuewei Wu, Stuart A Aaronson, Celina Ang, Vito W Rebecca, Brian D Brown, Avner Schlessinger, Meenhard Herlyn, Qi Wang, David E Shaw, Poulikos I Poulikakos
Exploiting Allosteric Properties of RAF and MEK Inhibitors to Target Therapy-Resistant Tumors Driven by Oncogenic BRAF Signaling. Cancer discovery 11 (7) (2021)
Sofia B Lizarraga, Li Ma, Abbie M Maguire, Laura I van Dyck, Qing Wu, Qing Ouyang, Brian C Kavanaugh, Dipal Nagda, Liane L Livi, Matthew F Pescosolido, Michael Schmidt, Shanique Alabi, Mara H Cowen, Paul Brito-Vargas, Diane Hoffman-Kim, Ece D Gamsiz Uzun, Avner Schlessinger, Richard N Jones, Eric M Morrow
Human neurons from Christianson syndrome iPSCs reveal mutation-specific responses to rescue strategies. Science translational medicine 13 (580) (2021)
Rayees Rahman, Arad Kodesh, Stephen Z Levine, Sven Sandin, Abraham Reichenberg, Avner Schlessinger
Identification of newborns at risk for autism using electronic medical records and machine learning. European psychiatry : the journal of the Association of European Psychiatrists 63 (1) (2020)
Johan G C van Hasselt, Rayees Rahman, Jens Hansen, Alan Stern, Jaehee V Shim, Yuguang Xiong, Amanda Pickard, Gomathi Jayaraman, Bin Hu, Milind Mahajan, James M Gallo, Joseph Goldfarb, Eric A Sobie, Marc R Birtwistle, Avner Schlessinger, Evren U Azeloglu, Ravi Iyengar
Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity. Nature communications 11 (1) (2020)
Susmita Khamrui, Peter M U Ung, Cody Secor, Avner Schlessinger, Michael B Lazarus
High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4. Journal of the American Chemical Society 142 (1) (2019)
Elias Ndaru, Rachel-Ann A Garibsingh, YueYue Shi, Evan Wallace, Paul Zakrepine, Jiali Wang, Avner Schlessinger, Christof T Grewer
Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds. The Journal of general physiology 151 (3) (2019)
Peter H Liu, Richa B Shah, Yuanyuan Li, Arshi Arora, Peter Man-Un Ung, Renuka Raman, Andrej Gorbatenko, Shingo Kozono, Xiao Zhen Zhou, Vincent Brechin, John M Barbaro, Ruth Thompson, Richard M White, Julio A Aguirre-Ghiso, John V Heymach, Kun Ping Lu, Jose M Silva, Katherine S Panageas, Avner Schlessinger, Robert G Maki, Heath D Skinner, Elisa de Stanchina, Samuel Sidi
An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nature cell biology 21 (2) (2019)
Peter Man-Un Ung, Masahiro Sonoshita, Alex P Scopton, Arvin C Dar, Ross L Cagan, Avner Schlessinger
Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network. PLoS computational biology 15 (4) (2019)
Huan-Chieh Chien, Claire Colas, Karissa Finke, Seth Springer, Laura Stoner, Arik A Zur, Brooklynn Venteicher, Jerome Campbell, Colton Hall, Andrew Flint, Evan Augustyn, Christopher Hernandez, Nathan Heeren, Logan Hansen, Abby Anthony, Justine Bauer, Dimitrios Fotiadis, Avner Schlessinger, Kathleen M Giacomini, Allen A Thomas
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). Journal of medicinal chemistry 61 (16) (2018)
Claire Colas, Masayuki Masuda, Kazuaki Sugio, Seiji Miyauchi, Yongjun Hu, David E Smith, Avner Schlessinger
Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1. Molecular pharmaceutics 14 (12) (2017)