Jonathan K Watts (Jonathan Watts)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 50

Top Topics

High Efficiency

Top Venues

Nucleic acids research

Nature communications

The CRISPR journal

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Samantha L Sarli, Hassan H Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Holly R McEachern, Chantal M Ferguson, Dimas Echeverria Moreno, Jonathan Lee, Jacquelyn Sousa, Hanadi F Sleiman, Anastasia Khvorova, Jonathan K Watts
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Nucleic acids research 52 (9) (2024)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Hailey Feinzig, Hanbing Cao, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature communications 15 (1) (2024)
Samantha L Sarli, Hassan H Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Holly R McEachern, Chantal M Ferguson, Dimas Echeverria Moreno, Jonathan Lee, Jacquelyn Sousa, Hanadi F Sleiman, Anastasia Khvorova, Jonathan K Watts
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Nucleic acids research 52 (9) (2024)
Chantal M Ferguson, Bruno M D C Godinho, Dimas Echeverria Moreno, Matthew R Hassler, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh, Julia F Alterman, Vignesh Narayan Hariharan, Pranathi Meda Krishnamurthy, Jonathan K Watts, Eveny Rogaev, Anastasia Khvorova
A combinatorial approach for achieving CNS-selective RNAi. Nucleic acids research 52 (9) (2024)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Hailey Feinzig, Hanbing Cao, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature communications 15 (1) (2024)
Chantal M Ferguson, Bruno M D C Godinho, Dimas Echeverria Moreno, Matthew R Hassler, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh, Julia F Alterman, Vignesh Narayan Hariharan, Pranathi Meda Krishnamurthy, Jonathan K Watts, Eveny Rogaev, Anastasia Khvorova
A combinatorial approach for achieving CNS-selective RNAi. Nucleic acids research 52 (9) (2024)
Samantha L Sarli, Hassan H Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Holly R McEachern, Chantal M Ferguson, Dimas Echeverria Moreno, Jonathan Lee, Jacquelyn Sousa, Hanadi F Sleiman, Anastasia Khvorova, Jonathan K Watts
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Nucleic acids research 52 (9) (2024)
Chantal M Ferguson, Bruno M D C Godinho, Dimas Echeverria Moreno, Matthew R Hassler, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh, Julia F Alterman, Vignesh Narayan Hariharan, Pranathi Meda Krishnamurthy, Jonathan K Watts, Eveny Rogaev, Anastasia Khvorova
A combinatorial approach for achieving CNS-selective RNAi. Nucleic acids research 52 (9) (2024)
Chantal M Ferguson, Bruno M D C Godinho, Dimas Echeverria Moreno, Matthew R Hassler, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh, Julia F Alterman, Vignesh Narayan Hariharan, Pranathi Meda Krishnamurthy, Jonathan K Watts, Eveny Rogaev, Anastasia Khvorova
A combinatorial approach for achieving CNS-selective RNAi. Nucleic acids research 52 (9) (2024)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Hailey Feinzig, Hanbing Cao, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature communications 15 (1) (2024)
Samantha L Sarli, Hassan H Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Holly R McEachern, Chantal M Ferguson, Dimas Echeverria Moreno, Jonathan Lee, Jacquelyn Sousa, Hanadi F Sleiman, Anastasia Khvorova, Jonathan K Watts
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Nucleic acids research (2024)
Chantal M Ferguson, Bruno M D C Godinho, Dimas Echeverria Moreno, Matthew R Hassler, Lorenc Vangjeli, Jacquelyn Sousa, Nicholas McHugh, Julia F Alterman, Vignesh Narayan Hariharan, Pranathi Meda Krishnamurthy, Jonathan K Watts, Eveny Rogaev, Anastasia Khvorova
A combinatorial approach for achieving CNS-selective RNAi. Nucleic acids research (2024)
Samantha L Sarli, Hassan H Fakih, Karen Kelly, Gitali Devi, Julia M Rembetsy-Brown, Holly R McEachern, Chantal M Ferguson, Dimas Echeverria Moreno, Jonathan Lee, Jacquelyn Sousa, Hanadi F Sleiman, Anastasia Khvorova, Jonathan K Watts
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Nucleic acids research 52 (9) (2024)
Rachael Miller, Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Brianna Bramato, Nozomi Yamada, Julia F Alterman, Dimas Echeveria, Ken Yamada, Jonathan K Watts, Christelle Anaclet, Marian DiFiglia, Anastasia Khvorova, Neil Aronin
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca 2+ and Mg 2+ in the formulation. bioRxiv : the preprint server for biology (2024)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Haoyang Cheng, Nicholas Gaston, Hailey Feinzig, Hanbing Cao, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature communications 15 (1) (2024)
Rachael Miller, Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Brianna Bramato, Nazomi Yamada, Julia F Alterman, Dimas Echeveria, Ken Yamada, Jonathan K Watts, Christelle Anaclet, Marian DiFiglia, Anastasia Khvorova, Neil Aronin
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation. bioRxiv : the preprint server for biology (2024)
Feng Wang, Ezequiel Hernán Calvo Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J Kartje, Pranathi Meda Krishnamurthy, Jonathan Lee, Michael R Green, Athma A Pai, Jonathan K Watts
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic acids research 50 (22) (2023)
Feng Wang, Ezequiel Hernán Calvo Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J Kartje, Pranathi Meda Krishnamurthy, Jonathan Lee, Michael R Green, Athma A Pai, Jonathan K Watts
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic acids research 50 (22) (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Feng Wang, Ezequiel Hernán Calvo Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J Kartje, Pranathi Meda Krishnamurthy, Jonathan Lee, Michael R Green, Athma A Pai, Jonathan K Watts
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic acids research 50 (22) (2023)
Sneha Shah, Kevin J Sharp, Sithara Raju Ponny, Jonathan Lee, Jonathan K Watts, Elizabeth Berry-Kravis, Joel D Richter
Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP. Proceedings of the National Academy of Sciences of the United States of America 120 (27) (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Han Zhang, Karen Kelly, Jonathan Lee, Dimas Echeverria Moreno, David A Cooper, Rebecca Panwala, Zexiang Chen, Nicholas Gaston, Gregory A Newby, Jun Xie, David R Liu, Guangping Gao, Scot A Wolfe, Anastasia Khvorova, Jonathan K Watts, Erik J Sontheimer
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo . bioRxiv : the preprint server for biology (2023)
Sneha Shah, Kevin J Sharp, Sithara Raju Ponny, Jonathan Lee, Jonathan K Watts, Elizabeth Berry-Kravis, Joel D Richter
Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP. Proceedings of the National Academy of Sciences of the United States of America 120 (27) (2023)
Bin Liu, Xiaolong Dong, Chunwei Zheng, David Keener, Zexiang Chen, Haoyang Cheng, Jonathan K Watts, Wen Xue, Erik J Sontheimer
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates. Nature biotechnology (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Samuel R Hildebrand, Adam K Hedger, Jonathan K Watts, Anastasia Khvorova
Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors. RNA (New York, N.Y.) (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Feng Wang, Ezequiel Hernán Calvo Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J Kartje, Pranathi Meda Krishnamurthy, Jonathan Lee, Michael R Green, Athma A Pai, Jonathan K Watts
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic acids research 50 (22) (2023)
Gitali Devi, Adam K Hedger, Richard J Whitby, Jonathan K Watts
Double Click: Unexpected 1:2 Stoichiometry in a Norbornene-Tetrazine Reaction. The Journal of organic chemistry (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Han Zhang, Karen Kelly, Jonathan Lee, Dimas Echeverria Moreno, David Cooper, Rebecca Panwala, Nadia Amrani, Zexiang Chen, Nicholas Gaston, Atish Wagh, Gregory A Newby, Jun Xie, David R Liu, Guangping Gao, Scot A Wolfe, Anastasia Khvorova, Jonathan K Watts, Erik J Sontheimer
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo. Nucleic acids research (2023)
Sneha Shah, Kevin J Sharp, Sithara Raju Ponny, Jonathan Lee, Jonathan K Watts, Elizabeth Berry-Kravis, Joel D Richter
Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP. Proceedings of the National Academy of Sciences of the United States of America 120 (27) (2023)
Zexiang Chen, Suet-Yan Kwan, Aamir Mir, Max Hazeltine, Minwook Shin, Shun-Qing Liang, Io Long Chan, Karen Kelly, Krishna S Ghanta, Nicholas Gaston, Yueying Cao, Jun Xie, Guangping Gao, Wen Xue, Erik J Sontheimer, Jonathan K Watts
A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The CRISPR journal 6 (6) (2023)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Nicholas Gaston, Haoyang Cheng, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope. bioRxiv : the preprint server for biology (2023)
Nathan Bamidele, Han Zhang, Xiaolong Dong, Nicholas Gaston, Haoyang Cheng, Karen Kelly, Jonathan K Watts, Jun Xie, Guangping Gao, Erik J Sontheimer
Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope. bioRxiv : the preprint server for biology (2023)
Shun-Qing Liang, Pengpeng Liu, Jordan L Smith, Esther Mintzer, Stacy Maitland, Xiaolong Dong, Qiyuan Yang, Jonathan Lee, Cole M Haynes, Julie Lihua Zhu, Jonathan K Watts, Erik J Sontheimer, Scot A Wolfe, Wen Xue
Genome-wide detection of CRISPR editing in vivo using GUIDE-tag. Nature communications 13 (1) (2022)
Zexiang Chen, Gitali Devi, Amena Arif, Phillip D Zamore, Erik J Sontheimer, Jonathan K Watts
Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing. ACS chemical biology 17 (5) (2022)
Atanu Maiti, Adam K Hedger, Wazo Myint, Vanivilasini Balachandran, Jonathan K Watts, Celia A Schiffer, Hiroshi Matsuo
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state. Nature communications 13 (1) (2022)
Feng Wang, Ezequiel Hernán Calvo Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J Kartje, Pranathi Meda Krishnamurthy, Jonathan Lee, Michael R Green, Athma A Pai, Jonathan K Watts
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic acids research (2022)
Gopinath Krishnan, Denitza Raitcheva, Daniel Bartlett, Mercedes Prudencio, Diane M McKenna-Yasek, Catherine Douthwright, Björn E Oskarsson, Shafeeq Ladha, Oliver D King, Sami J Barmada, Timothy M Miller, Robert Bowser, Jonathan K Watts, Leonard Petrucelli, Robert H Brown, Mark W Kankel, Fen-Biao Gao
Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD. Nature communications 13 (1) (2022)
Minwook Shin, Io Long Chan, Yuming Cao, Alisha M Gruntman, Jonathan Lee, Jacquelyn Sousa, Tomás C Rodríguez, Dimas Echeverria Moreno, Gitali Devi, Alexandre J Debacker, Michael P Moazami, Pranathi Meda Krishnamurthy, Julia M Rembetsy-Brown, Karen Kelly, Onur Yukselen, Elisa Donnard, Teagan J Parsons, Anastasia Khvorova, Erik J Sontheimer, René Maehr, Manuel Garber, Jonathan K Watts
Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts. Nucleic acids research 50 (15) (2022)
Krishna S Ghanta, Zexiang Chen, Aamir Mir, Gregoriy A Dokshin, Pranathi M Krishnamurthy, Yeonsoo Yoon, Judith Gallant, Ping Xu, Xiao-Ou Zhang, Ahmet Rasit Ozturk, Masahiro Shin, Feston Idrizi, Pengpeng Liu, Hassan Gneid, Alireza Edraki, Nathan D Lawson, Jaime A Rivera-Pérez, Erik J Sontheimer, Jonathan K Watts, Craig C Mello
5'-Modifications improve potency and efficacy of DNA donors for precision genome editing. eLife 10 (2021)
Hélène Tran, Michael P Moazami, Huiya Yang, Diane McKenna-Yasek, Catherine L Douthwright, Courtney Pinto, Jake Metterville, Min-Wook Shin, Nitasha Sanil, Craig Dooley, Ajit Puri, Alexandra Weiss, Nicholas Wightman, Heather Gray-Edwards, Miklos Marosfoi, Robert M King, Thomas Kenderdine, Daniele Fabris, Robert Bowser, Jonathan K Watts, Robert H Brown
Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide. Nature medicine 28 (1) (2021)
Jonathan K Watts, Robert H Brown, Anastasia Khvorova
Nucleic Acid Therapeutics for Neurological Diseases. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 16 (2) (2020)
Marlies E Oomen, Adam K Hedger, Jonathan K Watts, Job Dekker
Detecting chromatin interactions between and along sister chromatids with SisterC. Nature methods 17 (10) (2020)
Maire F Osborn, Andrew H Coles, Diane Golebiowski, Dimas Echeverria, Michael P Moazami, Jonathan K Watts, Miguel Sena-Esteves, Anastasia Khvorova
Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs. Molecular cancer therapeutics 17 (6) (2018)
Vivek K Sharma, Maire F Osborn, Matthew R Hassler, Dimas Echeverria, Socheata Ly, Egor A Ulashchik, Yury V Martynenko-Makaev, Vadim V Shmanai, Tatiana A Prikazchikova, Anastasia Khvorova, Jonathan K Watts
Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo. Bioconjugate chemistry 29 (7) (2018)
Alexandre J Debacker, Vivek K Sharma, Pranathi Meda Krishnamurthy, Daniel O'Reilly, Rachel Greenhill, Jonathan K Watts
Next-Generation Peptide Nucleic Acid Chimeras Exhibit High Affinity and Potent Gene Silencing. Biochemistry 58 (6) (2018)